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HEALTH PROFESSIONAL · SOURCE READING

Palliative chemotherapy and other systemic therapy

Source: Cervical Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: May 13, 2025 · Captured 2026-09-09.

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Context: Treatment of Stage IVB and Recurrent Cervical Cancer / Treatment Options for Stage IVB and Recurrent Cervical Cancer

Chemotherapy can be used for palliation. Drugs used for palliative chemotherapy are shown in Table 6.

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Table 6. Drugs Used to Treat Stage IVB and Recurrent Cervical Cancer
Drug NameResponse Rate
Cisplatin [8]15%–25%
Ifosfamide [9,10]15%–30%
Paclitaxel [11]17%
Irinotecan [12]21% in patients previously treated with chemotherapy
Bevacizumab [13]11%; 24% survived progression free for at least 6 months, as seen in GOG-0227C (NCT00025233)
Ifosfamide/cisplatin [14,15]31%
Paclitaxel/cisplatin [16]46%
Cisplatin/gemcitabine [17]41%
Cisplatin/topotecan [18]27%
Cisplatin/vinorelbine [19]30%
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