TriangleFOR PATIENTS · SOURCE READING
Treating metastatic or stage IV (also called stage 4) triple-negative breast cancer
Source: Triple-Negative Breast Cancer Treatment, National Cancer Institute.
Source updated: Not stated in this source · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
NCI patient treatment article for this disease Exact source article; not a clinically reviewed indication or current-standard recommendation.
Context: Triple-Negative Breast Cancer Treatment
Treating metastatic or stage IV (also called stage 4) triple-negative breast cancer
In metastatic (stage IV or stage 4) TNBC, the cancer has spread beyond the breast and nearby lymph nodes to distant parts of the body. Treatment for stage IV TNBC is focused on managing the disease and improving quality of life. Treatment options may include:
chemotherapy, which is usually the first treatment
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targeted therapy, such as olaparib (for those with a BRCA1 or BRCA2 gene mutation) or sacituzumab govitecan
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immunotherapy with pembrolizumab
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surgery, such as a mastectomy, to improve symptoms caused by a painful breast tumor or skin lesions
radiation therapy with strontium-89 to relieve pain from cancer that has spread to bones throughout the body
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radiation to the bones, brain, spinal cord, breast, or chest wall, or areas causing pain or discomfort
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Preserved source evidence · Independent clinical review pending · Not medical advice