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Treatment Options for Soft Tissue Sarcoma
Source: Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: February 21, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Treatment Option Overview for Soft Tissue Sarcoma
| Stage (TNMG Staging Criteria) | Treatment Options | |
|---|---|---|
| T = primary tumor; N = regional lymph node; M = distant metastasis; G = grade. | ||
| Stage I soft tissue sarcoma | Surgery | |
| Surgery with radiation therapy | ||
| High-dose radiation therapy | ||
| Stage II and node-negative stage III soft tissue sarcoma | Surgery | |
| Surgery with radiation therapy | ||
| Radiation therapy and/or chemotherapy followed by surgery | ||
| High-dose radiation therapy | ||
| Advanced stage III (N1) soft tissue sarcoma | Surgery and lymphadenectomy | |
| Surgery with neoadjuvant or adjuvant therapy | ||
| Stage IV soft tissue sarcoma | Chemotherapy | |
| Histology-specific targeted or immunotherapy treatment | ||
| Surgery | ||
| Recurrent soft tissue sarcoma | Surgery with or without radiation therapy | |
| Chemotherapy and targeted therapy | ||
| Immune checkpoint inhibitor therapy (under clinical evaluation) | ||
Source links and citations
- TNMG Staging Criteria
- Surgery
- Surgery with radiation therapy
- High-dose radiation therapy
- Surgery
- Surgery with radiation therapy
- Radiation therapy and/or chemotherapy followed by surgery
- High-dose radiation therapy
- Surgery and lymphadenectomy
- Surgery with neoadjuvant or adjuvant therapy
- Chemotherapy
- Histology-specific targeted or immunotherapy treatment
- Surgery
- Surgery with or without radiation therapy
- Chemotherapy and targeted therapy
- Immune checkpoint inhibitor therapy
Preserved source evidence · Not medical advice