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Retroperitoneal tumors
Source: Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: February 21, 2025 · Captured 2026-09-09.
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Context: Treatment Option Overview for Soft Tissue Sarcoma / Surgery
Effective treatment of retroperitoneal sarcomas requires removal of all gross disease while sparing adjacent viscera not invaded by tumor. The prognosis for patients with high-grade retroperitoneal sarcomas is less favorable than for patients with tumors at other sites, partly because of the difficulty in completely resecting these tumors and the dose-limiting toxicity of high-dose radiation therapy on visceral organs.[13-16]
Local disease control is crucial in patients with retroperitoneal sarcomas. Disease-specific mortality caused by local recurrence (without synchronous metastasis) was reported in up to 77% of patients with retroperitoneal sarcomas compared with 9% of patients with extremity or trunk sarcomas.[17] An additional consideration in retroperitoneal sarcomas is the extent of surgery.
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Evidence (extended surgical resection):
A series of 382 patients with retroperitoneal sarcoma in a multivariate analysis showed the following results:[18]
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A series of 382 patients with retroperitoneal sarcoma in a multivariate analysis showed the following results:[18]
Patients treated with extended surgical resection had a 3.3-fold lower rate of local recurrence compared with patients who underwent simple complete resection.
A series of 382 patients with retroperitoneal sarcoma in a multivariate analysis showed the following results:[18]
Extended surgical resection was not associated with improved survival.
A series of 382 patients with retroperitoneal sarcoma in a multivariate analysis showed the following results:[18]
In a follow-up analysis, a 66% overall survival (OS) rate was observed in the extended surgical resection cohort compared with a 48% OS rate in historic controls.[19]
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Publication references
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Preserved source evidence · Not medical advice