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Treatment of Advanced Classic HL
Source: Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: February 12, 2025 · Captured 2026-09-09.
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The following adverse prognostic factors for advanced classic Hodgkin lymphoma (HL) have been combined into the International Prognostic Score (IPS) for advanced-stage HL:[1]
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Albumin level lower than 40 g/L.
Hemoglobin level lower than 105 g/L.
Male sex.
Aged 45 years or older.
Stage IV disease.
White blood cell (WBC) count of 15 × 109/L or higher.
Absolute lymphocyte count lower than 0.6 × 109/L or a lymphocyte count higher than 8% of the total WBC count.
| No. of Risk Factors | 5-Year FFP (%) | 5-Year OS (%) |
|---|---|---|
| FFP = freedom from progression; No. = number; OS = overall survival. | ||
| 0 | 88 | 98 |
| 1 | 84 | 97 |
| 2 | 80 | 92 |
| 3 | 74 | 91 |
| 4 | 67 | 88 |
| ≥5 | 62 | 73 |
Even the highest-risk patients in this index have a 5-year freedom from progression rate above 60% and a 5-year overall survival (OS) rate above 70%.[1]
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Preserved source evidence · Not medical advice