Treatment of Recurrent Adrenocortical Carcinoma

Deciding to treat patients with recurrent adrenocortical carcinoma (ACC), and what treatment to use, depends on many factors, including previous treatment, site of recurrence, and individual patient considerations. Local recurrence and selected sites of metastatic disease can sometimes be palliated by surgery or radiation therapy. Although recurrent ACC is not considered curable, palliation of hormonal symptoms and occasional 5-year survivals can be achieved.[1] However, substantial morbidity is associated with resection of recurrent tumors.

Clinical trials, including phase I and II trials of newer chemotherapeutic and biological agents, are appropriate and should be considered.