Skip to content
TriangleGet started
← Full study record

NCT06039384 · OUTCOME

Tmax of INCB099280 When Administered Alone and in Combination With Adagrasib

A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation · Source last updated 2026-09-08

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
hours
Interval / dispersion
Full Range
Time frame
Day -1; Cycle 1 Day 8; Day 1 of Cycles 1, 2, 4, 6, 8, 12, and every fourth cycle thereafter

What was measured

During the lead-in period, INCB099280 was administered as monotherapy. During the treatment period, INCB099280 and adagrasib were coadministered. tmax was defined as the time to the maximum concentration of INCB099280. Lead-in Period: Day -1 and Cycle 1 Day 8: predose and 0.5, 1, 2, 3, 4, 6, 8, and 12 hours postdose; predose on Day 1 of Cycles 1, 2, 4, 6, 8, 12, and every fourth cycle thereafter. Without Lead-in Period: Cycle 1 Day 8: predose and 1, 2, and 4 hours postdose; predose on Day 1 of Cycles 1, 2, 4, 6, 8, 12, and every fourth cycle thereafter.

Analysis population: PK-Evaluable Population

Groups in this outcome

INCB099280 50 mg QD Plus Adagrasib 400 mg BID

Participants received INCB099280 50 milligrams (mg) once daily (QD) plus adagrasib 400 mg twice daily (BID) for up to 2 years.

INCB099280 100 mg BID Plus Adagrasib 400 mg BID

Participants received INCB099280 100 mg BID plus adagrasib 400 mg BID for up to 2 years.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
INCB099280 50 mg QD Plus Adagrasib 400 mg BID3
INCB099280 100 mg BID Plus Adagrasib 400 mg BID3

Reported measurements

INCB099280 alone
Values in hours · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
INCB099280 50 mg QD Plus Adagrasib 400 mg BID4.2Not reported3.05.6Not reported
INCB099280 100 mg BID Plus Adagrasib 400 mg BID3.0Not reported2.96.0Not reported
INCB099280 administered with adagrasib
Values in hours · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
INCB099280 50 mg QD Plus Adagrasib 400 mg BID4.0Not reported2.86.0Not reported
INCB099280 100 mg BID Plus Adagrasib 400 mg BID2.5Not reported2.03.9Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        3.0
        upper Limit
        5.6
        value
        4.2
      2. group Id
        OG001
        lower Limit
        2.9
        upper Limit
        6.0
        value
        3.0
    title
    INCB099280 alone
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        2.8
        upper Limit
        6.0
        value
        4.0
      2. group Id
        OG001
        lower Limit
        2.0
        upper Limit
        3.9
        value
        2.5
    title
    INCB099280 administered with adagrasib
denoms
  1. counts
    1. group Id
      OG000
      value
      3
    2. group Id
      OG001
      value
      3
    units
    Participants
description
During the lead-in period, INCB099280 was administered as monotherapy. During the treatment period, INCB099280 and adagrasib were coadministered. tmax was defined as the time to the maximum concentration of INCB099280. Lead-in Period: Day -1 and Cycle 1 Day 8: predose and 0.5, 1, 2, 3, 4, 6, 8, and 12 hours postdose; predose on Day 1 of Cycles 1, 2, 4, 6, 8, 12, and every fourth cycle thereafter. Without Lead-in Period: Cycle 1 Day 8: predose and 1, 2, and 4 hours postdose; predose on Day 1 of Cycles 1, 2, 4, 6, 8, 12, and every fourth cycle thereafter.
dispersion Type
Full Range
groups
  1. description
    Participants received INCB099280 50 milligrams (mg) once daily (QD) plus adagrasib 400 mg twice daily (BID) for up to 2 years.
    id
    OG000
    title
    INCB099280 50 mg QD Plus Adagrasib 400 mg BID
  2. description
    Participants received INCB099280 100 mg BID plus adagrasib 400 mg BID for up to 2 years.
    id
    OG001
    title
    INCB099280 100 mg BID Plus Adagrasib 400 mg BID
param Type
MEDIAN
population Description
PK-Evaluable Population
reporting Status
POSTED
time Frame
Day -1; Cycle 1 Day 8; Day 1 of Cycles 1, 2, 4, 6, 8, 12, and every fourth cycle thereafter
title
Tmax of INCB099280 When Administered Alone and in Combination With Adagrasib
type
SECONDARY
unit Of Measure
hours

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Independent clinical review pending · Not medical advice