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NCT05986682 · BASELINE

Baseline characteristics

Real-World Analysis of Belantamab Mafodotin Care Patterns in Patients With Relapsed and/or Refractory Multiple Myeloma · Source last updated 2025-02-03

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      30
    units
    Participants
groups
  1. description
    Participants with relapsed and/or refractory multiple myeloma who were treated with Belantamab Mafodotin - blmf (BLENREP) in the DCI Oncology outpatient clinics between August 5, 2020 and November 7, 2023.
    id
    BG000
    title
    Multiple Myeloma/Blenrep Participants
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          45
          upper Limit
          87
          value
          68
    description
    Age at Treatment Initiation (Baseline)
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          43
          upper Limit
          85
          value
          61
    description
    Age at Multiple Myeloma Diagnosis
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          16
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          14
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          29
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          0
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          14
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          14
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          1
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          1
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          30
      title
      United States
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Region of Enrollment
    unit Of Measure
    Participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          19
        title
        Medicare + Commercial
      2. measurements
        1. group Id
          BG000
          value
          3
        title
        Medicare + Military
      3. measurements
        1. group Id
          BG000
          value
          1
        title
        Medicare + Medicaid
      4. measurements
        1. group Id
          BG000
          value
          6
        title
        Commercial Alone
      5. measurements
        1. group Id
          BG000
          value
          1
        title
        Medicaid Alone
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Current Payer type
    unit Of Measure
    Participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        title
        At Duke
      2. measurements
        1. group Id
          BG000
          value
          15
        title
        External Location
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Diagnosis Location
    unit Of Measure
    Participants
  9. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          29
      title
      >= 10% Bone Marrow Plasma Cells
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          9
      title
      Plasmacytoma (Total)
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          8
      title
      Bone Plasmacytoma
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          1
      title
      Extramedullary Plasmacytoma
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          17
      title
      >60% Bone Marrow plasma cells
    6. categories
      1. measurements
        1. group Id
          BG000
          value
          14
      title
      ≥ 100 serum free light chain (FLC) ratio
    7. categories
      1. measurements
        1. group Id
          BG000
          value
          5
      title
      >1 focal lesion on MRI
    8. categories
      1. measurements
        1. group Id
          BG000
          value
          6
      title
      Hypercalcemia
    9. categories
      1. measurements
        1. group Id
          BG000
          value
          5
      title
      Renal Insufficiency
    10. categories
      1. measurements
        1. group Id
          BG000
          value
          17
      title
      Anemia
    11. categories
      1. measurements
        1. group Id
          BG000
          value
          21
      title
      ≥ 1 Bone lesion (X-ray, CT, PET)
    description
    Participants may have more than one diagnostic characteristic of MM.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Multiple Myeloma (MM) Diagnostic Characteristics
    unit Of Measure
    Participants
  10. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          16
        title
        IgG
      2. measurements
        1. group Id
          BG000
          value
          9
        title
        IgA
      3. measurements
        1. group Id
          BG000
          value
          0
        title
        IgD
      4. measurements
        1. group Id
          BG000
          value
          0
        title
        IgE
      5. measurements
        1. group Id
          BG000
          value
          0
        title
        IgM
      6. measurements
        1. group Id
          BG000
          value
          0
        title
        Light Chain Only
      7. measurements
        1. group Id
          BG000
          value
          5
        title
        Non-secretory
    description
    Subtype of MM by Immunoglobulin - as determined at Diagnosis
    param Type
    COUNT_OF_PARTICIPANTS
    title
    MM Subtype - Immunoglobulin (Ig)
    unit Of Measure
    Participants
  11. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          18
        title
        Kappa
      2. measurements
        1. group Id
          BG000
          value
          12
        title
        Lambda
    description
    Subtype of MM by involved serum free light chain - as determined at Diagnosis
    param Type
    COUNT_OF_PARTICIPANTS
    title
    MM Subtype - Involved Serum Free Light Chain
    unit Of Measure
    Participants
  12. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        title
        R-ISS I
      2. measurements
        1. group Id
          BG000
          value
          5
        title
        R-ISS II
      3. measurements
        1. group Id
          BG000
          value
          23
        title
        Unknown
    description
    The Revised International Staging System (R-ISS) is a prognostic staging system used to stratify patients with MM based on genetic risk as assessed by fluorescence in-situ hybridization (FISH) and routinely used lab values. The R-ISS system consists of stage I: serum beta2-microglobulin \< 3.5 milligram per liter (mg/L), albumin \>= 3.5 gram per deciliter (g/dL), standard-risk chromosomal abnormalities (CA) by FISH and normal lactate dehydrogenase level (LDH); stage II: neither R-ISS stage I nor stage III; and stage III: beta2-microglobulin \>= 5.5mg/L and either high-risk CA by FISH or high LDH.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    R-ISS Score
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      30
    units
    Participants
groups
  1. description
    Participants with relapsed and/or refractory multiple myeloma who were treated with Belantamab Mafodotin - blmf (BLENREP) in the DCI Oncology outpatient clinics between August 5, 2020 and November 7, 2023.
    id
    BG000
    title
    Multiple Myeloma/Blenrep Participants
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          45
          upper Limit
          87
          value
          68
    description
    Age at Treatment Initiation (Baseline)
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          43
          upper Limit
          85
          value
          61
    description
    Age at Multiple Myeloma Diagnosis
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          16
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          14
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          29
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          0
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          14
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          14
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          1
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          1
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          30
      title
      United States
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Region of Enrollment
    unit Of Measure
    Participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          19
        title
        Medicare + Commercial
      2. measurements
        1. group Id
          BG000
          value
          3
        title
        Medicare + Military
      3. measurements
        1. group Id
          BG000
          value
          1
        title
        Medicare + Medicaid
      4. measurements
        1. group Id
          BG000
          value
          6
        title
        Commercial Alone
      5. measurements
        1. group Id
          BG000
          value
          1
        title
        Medicaid Alone
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Current Payer type
    unit Of Measure
    Participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        title
        At Duke
      2. measurements
        1. group Id
          BG000
          value
          15
        title
        External Location
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Diagnosis Location
    unit Of Measure
    Participants
  9. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          29
      title
      >= 10% Bone Marrow Plasma Cells
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          9
      title
      Plasmacytoma (Total)
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          8
      title
      Bone Plasmacytoma
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          1
      title
      Extramedullary Plasmacytoma
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          17
      title
      >60% Bone Marrow plasma cells
    6. categories
      1. measurements
        1. group Id
          BG000
          value
          14
      title
      ≥ 100 serum free light chain (FLC) ratio
    7. categories
      1. measurements
        1. group Id
          BG000
          value
          5
      title
      >1 focal lesion on MRI
    8. categories
      1. measurements
        1. group Id
          BG000
          value
          6
      title
      Hypercalcemia
    9. categories
      1. measurements
        1. group Id
          BG000
          value
          5
      title
      Renal Insufficiency
    10. categories
      1. measurements
        1. group Id
          BG000
          value
          17
      title
      Anemia
    11. categories
      1. measurements
        1. group Id
          BG000
          value
          21
      title
      ≥ 1 Bone lesion (X-ray, CT, PET)
    description
    Participants may have more than one diagnostic characteristic of MM.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Multiple Myeloma (MM) Diagnostic Characteristics
    unit Of Measure
    Participants
  10. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          16
        title
        IgG
      2. measurements
        1. group Id
          BG000
          value
          9
        title
        IgA
      3. measurements
        1. group Id
          BG000
          value
          0
        title
        IgD
      4. measurements
        1. group Id
          BG000
          value
          0
        title
        IgE
      5. measurements
        1. group Id
          BG000
          value
          0
        title
        IgM
      6. measurements
        1. group Id
          BG000
          value
          0
        title
        Light Chain Only
      7. measurements
        1. group Id
          BG000
          value
          5
        title
        Non-secretory
    description
    Subtype of MM by Immunoglobulin - as determined at Diagnosis
    param Type
    COUNT_OF_PARTICIPANTS
    title
    MM Subtype - Immunoglobulin (Ig)
    unit Of Measure
    Participants
  11. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          18
        title
        Kappa
      2. measurements
        1. group Id
          BG000
          value
          12
        title
        Lambda
    description
    Subtype of MM by involved serum free light chain - as determined at Diagnosis
    param Type
    COUNT_OF_PARTICIPANTS
    title
    MM Subtype - Involved Serum Free Light Chain
    unit Of Measure
    Participants
  12. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        title
        R-ISS I
      2. measurements
        1. group Id
          BG000
          value
          5
        title
        R-ISS II
      3. measurements
        1. group Id
          BG000
          value
          23
        title
        Unknown
    description
    The Revised International Staging System (R-ISS) is a prognostic staging system used to stratify patients with MM based on genetic risk as assessed by fluorescence in-situ hybridization (FISH) and routinely used lab values. The R-ISS system consists of stage I: serum beta2-microglobulin \< 3.5 milligram per liter (mg/L), albumin \>= 3.5 gram per deciliter (g/dL), standard-risk chromosomal abnormalities (CA) by FISH and normal lactate dehydrogenase level (LDH); stage II: neither R-ISS stage I nor stage III; and stage III: beta2-microglobulin \>= 5.5mg/L and either high-risk CA by FISH or high LDH.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    R-ISS Score
    unit Of Measure
    Participants

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Preserved source evidence · Not medical advice