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NCT05460273 · OUTCOME

Duration of Response (DoR), Assessed by ICR

A Study of Dato-DXd in Chinese Patients With Advanced Non-Small Cell Lung Cancer, Triple-negative Breast Cancer and Other Solid Tumors (TROPION-PanTumor02) · Source last updated 2026-08-31

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
Month
Interval / dispersion
95% Confidence Interval
Time frame
TNBC cohort: from enrollment to 13 months post last subject dose with a median of 12 months follow up. NSCLC cohort: from enrollment to 20 months post last subject dose with a median of 16.7 months follow up.

What was measured

Duration of response is defined as the time from the date of first documented response (which is subsequently confirmed) until date of documented progression per RECIST 1.1, as assessed by ICR, or death due to any cause.

Analysis population: RES: Enrolled participants who received at least one dose of study intervention and had measurable disease at baseline by ICR. The analysis for DOR assessed by ICR was based on the responders in the RES of each cohort.

Groups in this outcome

TNBC Cohort

Final Analysis with DCO on 06May2024

NSCLC Cohort

Final Analysis with DCO on 27Nov2024

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
TNBC Cohort26
NSCLC Cohort18

Reported measurements

Source class 1
Values in Month · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
TNBC Cohort6.7Not reported4.5312.6Not reported
NSCLC Cohort8.3Not reported5.99.4Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        4.53
        upper Limit
        12.6
        value
        6.7
      2. group Id
        OG001
        lower Limit
        5.9
        upper Limit
        9.4
        value
        8.3
denoms
  1. counts
    1. group Id
      OG000
      value
      26
    2. group Id
      OG001
      value
      18
    units
    Participants
description
Duration of response is defined as the time from the date of first documented response (which is subsequently confirmed) until date of documented progression per RECIST 1.1, as assessed by ICR, or death due to any cause.
dispersion Type
95% Confidence Interval
groups
  1. description
    Final Analysis with DCO on 06May2024
    id
    OG000
    title
    TNBC Cohort
  2. description
    Final Analysis with DCO on 27Nov2024
    id
    OG001
    title
    NSCLC Cohort
param Type
MEDIAN
population Description
RES: Enrolled participants who received at least one dose of study intervention and had measurable disease at baseline by ICR. The analysis for DOR assessed by ICR was based on the responders in the RES of each cohort.
reporting Status
POSTED
time Frame
TNBC cohort: from enrollment to 13 months post last subject dose with a median of 12 months follow up. NSCLC cohort: from enrollment to 20 months post last subject dose with a median of 16.7 months follow up.
title
Duration of Response (DoR), Assessed by ICR
type
SECONDARY
unit Of Measure
Month

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice