NCT05255601 · OUTCOME
Concentration Trough (Ctrough)
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of Relatlimab Plus Nivolumab in Pediatric and Young Adults With Hodgkin and Non-Hodgkin Lymphoma · Source last updated 2026-06-26
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- GEOMETRIC_MEAN
- Unit
- ug/mL
- Interval / dispersion
- Geometric Coefficient of Variation
- Time frame
- Cycle 2 Day 1, Cycle 4 Day 1, Cycle 6 Day 1
What was measured
Concentration Trough (Ctrough) for Analyte BMS-986016 and BMS-936558
Analysis population: PK Population
Groups in this outcome
Part A - Flat Dosing (AF)
Participants received treatment with Relatlimab 160 mg + Nivolumab 480 mg Q4W
Part A - Age/Weight-based Dosing (AW)
Participant received treatment with Relatlimab 2 mg/kg + Nivolumab 6 mg/kg Q4W
Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 4 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 1 |
|---|
Reported measurements
Cycle 2 Day 1 - BMS986016
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 4 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 1 |
|---|
Values in ug/mL · Interval/dispersion: Geometric Coefficient of Variation| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Part A - Flat Dosing (AF) | 9.50 | 68 | Not reported | Not reported | Not reported |
|---|
| Part A - Age/Weight-based Dosing (AW) | 2.39 | NA | Not reported | Not reported | Unable to calculate geometric coefficient of variation due to low number of participants |
|---|
Cycle 4 Day 1 - BMS986016
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 4 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 0 |
|---|
Values in ug/mL · Interval/dispersion: Geometric Coefficient of Variation| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Part A - Flat Dosing (AF) | 20.52 | 66 | Not reported | Not reported | Not reported |
|---|
Cycle 6 Day 1 - BMS986016
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 2 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 0 |
|---|
Values in ug/mL · Interval/dispersion: Geometric Coefficient of Variation| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Part A - Flat Dosing (AF) | 23.53 | NA | Not reported | Not reported | Unable to calculate geometric coefficient of variation due to low number of participants |
|---|
Cycle 2 Day 1 - BMS-936558
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 4 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 1 |
|---|
Values in ug/mL · Interval/dispersion: Geometric Coefficient of Variation| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Part A - Flat Dosing (AF) | 40.32 | 46 | Not reported | Not reported | Not reported |
|---|
| Part A - Age/Weight-based Dosing (AW) | 17.80 | NA | Not reported | Not reported | Unable to calculate geometric coefficient of variation due to low number of participants |
|---|
Cycle 4 Day 1 - BMS-936558
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 4 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 0 |
|---|
Values in ug/mL · Interval/dispersion: Geometric Coefficient of Variation| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Part A - Flat Dosing (AF) | 79.80 | 53 | Not reported | Not reported | Not reported |
|---|
Cycle 6 Day 1 - BMS-936558
Analysis denominator · Participants
| Group | Source count |
|---|
| Part A - Flat Dosing (AF) | 2 |
|---|
| Part A - Age/Weight-based Dosing (AW) | 0 |
|---|
Values in ug/mL · Interval/dispersion: Geometric Coefficient of Variation| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Part A - Flat Dosing (AF) | 91.87 | NA | Not reported | Not reported | Unable to calculate geometric coefficient of variation due to low number of participants |
|---|
Complete source fields
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 68
- value
- 9.50
- comment
- Unable to calculate geometric coefficient of variation due to low number of participants
- group Id
- OG001
- spread
- NA
- value
- 2.39
- denoms
- counts
- group Id
- OG000
- value
- 4
- group Id
- OG001
- value
- 1
- units
- Participants
- title
- Cycle 2 Day 1 - BMS986016
- categories
- measurements
- group Id
- OG000
- spread
- 66
- value
- 20.52
- denoms
- counts
- group Id
- OG000
- value
- 4
- group Id
- OG001
- value
- 0
- units
- Participants
- title
- Cycle 4 Day 1 - BMS986016
- categories
- measurements
- comment
- Unable to calculate geometric coefficient of variation due to low number of participants
- group Id
- OG000
- spread
- NA
- value
- 23.53
- denoms
- counts
- group Id
- OG000
- value
- 2
- group Id
- OG001
- value
- 0
- units
- Participants
- title
- Cycle 6 Day 1 - BMS986016
- categories
- measurements
- group Id
- OG000
- spread
- 46
- value
- 40.32
- comment
- Unable to calculate geometric coefficient of variation due to low number of participants
- group Id
- OG001
- spread
- NA
- value
- 17.80
- denoms
- counts
- group Id
- OG000
- value
- 4
- group Id
- OG001
- value
- 1
- units
- Participants
- title
- Cycle 2 Day 1 - BMS-936558
- categories
- measurements
- group Id
- OG000
- spread
- 53
- value
- 79.80
- denoms
- counts
- group Id
- OG000
- value
- 4
- group Id
- OG001
- value
- 0
- units
- Participants
- title
- Cycle 4 Day 1 - BMS-936558
- categories
- measurements
- comment
- Unable to calculate geometric coefficient of variation due to low number of participants
- group Id
- OG000
- spread
- NA
- value
- 91.87
- denoms
- counts
- group Id
- OG000
- value
- 2
- group Id
- OG001
- value
- 0
- units
- Participants
- title
- Cycle 6 Day 1 - BMS-936558
- denoms
- counts
- group Id
- OG000
- value
- 4
- group Id
- OG001
- value
- 1
- units
- Participants
- description
- Concentration Trough (Ctrough) for Analyte BMS-986016 and BMS-936558
- dispersion Type
- Geometric Coefficient of Variation
- groups
- description
- Participants received treatment with Relatlimab 160 mg + Nivolumab 480 mg Q4W
- id
- OG000
- title
- Part A - Flat Dosing (AF)
- description
- Participant received treatment with Relatlimab 2 mg/kg + Nivolumab 6 mg/kg Q4W
- id
- OG001
- title
- Part A - Age/Weight-based Dosing (AW)
- param Type
- GEOMETRIC_MEAN
- population Description
- PK Population
- reporting Status
- POSTED
- time Frame
- Cycle 2 Day 1, Cycle 4 Day 1, Cycle 6 Day 1
- title
- Concentration Trough (Ctrough)
- type
- PRIMARY
- unit Of Measure
- ug/mL
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice
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