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NCT04971226 · OUTCOME

Pharmacokinetics (PK) of Asciminib: Cmax

A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP · Source last updated 2026-08-28

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
GEOMETRIC_MEAN
Unit
ng/mL
Interval / dispersion
Geometric Coefficient of Variation
Time frame
Week 2 (0 hours (h) pre-dose, 1h, 2h, 3h, 4h, 6h, 8h and 12h post dose)

What was measured

Cmax is the maximum serum concentration of asciminib during a dosing interval (mass x volume-1).

Analysis population: Full PK samples were collected at Week 2

Groups in this outcome

Asciminib (All Asciminib)

Patients took asciminib 80 mg QD under fasting conditions on ongoing basis.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Asciminib (All Asciminib)26

Reported measurements

Source class 1
Values in ng/mL · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
Asciminib (All Asciminib)147038.2Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        38.2
        value
        1470
denoms
  1. counts
    1. group Id
      OG000
      value
      26
    units
    Participants
description
Cmax is the maximum serum concentration of asciminib during a dosing interval (mass x volume-1).
dispersion Type
Geometric Coefficient of Variation
groups
  1. description
    Patients took asciminib 80 mg QD under fasting conditions on ongoing basis.
    id
    OG000
    title
    Asciminib (All Asciminib)
param Type
GEOMETRIC_MEAN
population Description
Full PK samples were collected at Week 2
reporting Status
POSTED
time Frame
Week 2 (0 hours (h) pre-dose, 1h, 2h, 3h, 4h, 6h, 8h and 12h post dose)
title
Pharmacokinetics (PK) of Asciminib: Cmax
type
SECONDARY
unit Of Measure
ng/mL

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice