Baseline characteristics

A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer · Source last updated 2026-09-24

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms

1. counts

   1. group Id

      BG000

      value

      1

   2. group Id

      BG001

      value

      1

   3. group Id

      BG002

      value

      5

   4. group Id

      BG003

      value

      10

   5. group Id

      BG004

      value

      17

   6. group Id

      BG005

      value

      13

   7. group Id

      BG006

      value

      5

   8. group Id

      BG007

      value

      4

   9. group Id

      BG008

      value

      8

   10. group Id

       BG009

       value

       31

   11. group Id

       BG010

       value

       95

   units

   Participants

groups

1. description

   Participants received TAK-186, Dose A as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose A is the lowest dose.

   id

   BG000

   title

   Dose Escalation Phase: TAK-186 - Dose A + Dexamethasone

2. description

   Participants received TAK-186, Dose B as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose B is higher than Dose A.

   id

   BG001

   title

   Dose Escalation Phase: TAK-186 - Dose B + Dexamethasone

3. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose C is higher than Dose B.

   id

   BG002

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose C + Dexamethasone

4. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose D on Day 8 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose D is higher than Dose B.

   id

   BG003

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose D + Dexamethasone

5. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and Dose E on Day 15 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose E is higher than Dose C and B.

   id

   BG004

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose C→ Dose E + Dexamethasone

6. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and Dose E on Day 15 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion and post-infusion. Dose E is higher than Dose C and B.

   id

   BG005

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose C→ Dose E + Double Dexamethasone

7. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and Dose F on Day 15 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose F is higher than Dose B and C.

   id

   BG006

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose C→ Dose F + Dexamethasone

8. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and Dose D on Day 15 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion. Dose D is higher than Dose B and C.

   id

   BG007

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose C→ Dose D + Dexamethasone

9. description

   Participants received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and Dose D on Day 15 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion and post-infusion. Dose D is higher than Dose B and C.

   id

   BG008

   title

   Dose Escalation Phase: TAK-186 - Dose B → Dose C→ Dose D + Double Dexamethasone

10. description

    Participants with non-small cell lung cancer (NSCLC) received TAK-186, Dose B on Day 1 followed by Dose C on Day 8 and Dose E on Day 15 and thereafter as an IV infusion, QW until PD, completion of 7 cycles in the event of no radiologic evidence of tumor regression, withdrawal of consent, or death. Dexamethasone was administered pre-infusion and post-infusion. Dose E is higher than Dose C and B.

    id

    BG009

    title

    Cohort Expansion Phase: NSCLC

11. description

    Total of all reporting groups

    id

    BG010

    title

    Total

measures

1. classes

   1. categories

      1. measurements

         1. comment

            Standard deviation was not estimable for a single participant.

            group Id

            BG000

            spread

            NA

            value

            61.0

         2. comment

            Standard deviation was not estimable for a single participant.

            group Id

            BG001

            spread

            NA

            value

            58.0

         3. group Id

            BG002

            spread

            4.71

            value

            52.2

         4. group Id

            BG003

            spread

            10.57

            value

            57.6

         5. group Id

            BG004

            spread

            12.79

            value

            54.4

         6. group Id

            BG005

            spread

            13.70

            value

            60.4

         7. group Id

            BG006

            spread

            6.58

            value

            58.6

         8. group Id

            BG007

            spread

            9.49

            value

            57.0

         9. group Id

            BG008

            spread

            9.20

            value

            57.0

         10. group Id

             BG009

             spread

             11.24

             value

             62.4

         11. group Id

             BG010

             spread

             11.21

             value

             58.7

   dispersion Type

   STANDARD_DEVIATION

   param Type

   MEAN

   title

   Age, Continuous

   unit Of Measure

   years

2. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            1

         3. group Id

            BG002

            value

            2

         4. group Id

            BG003

            value

            3

         5. group Id

            BG004

            value

            9

         6. group Id

            BG005

            value

            5

         7. group Id

            BG006

            value

            2

         8. group Id

            BG007

            value

            2

         9. group Id

            BG008

            value

            2

         10. group Id

             BG009

             value

             15

         11. group Id

             BG010

             value

             41

         title

         Female

      2. measurements

         1. group Id

            BG000

            value

            1

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            3

         4. group Id

            BG003

            value

            7

         5. group Id

            BG004

            value

            8

         6. group Id

            BG005

            value

            8

         7. group Id

            BG006

            value

            3

         8. group Id

            BG007

            value

            2

         9. group Id

            BG008

            value

            6

         10. group Id

             BG009

             value

             16

         11. group Id

             BG010

             value

             54

         title

         Male

   param Type

   COUNT_OF_PARTICIPANTS

   title

   Sex: Female, Male

   unit Of Measure

   Participants

3. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            0

         6. group Id

            BG005

            value

            0

         7. group Id

            BG006

            value

            1

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            0

         10. group Id

             BG009

             value

             1

         11. group Id

             BG010

             value

             2

         title

         Hispanic or Latino

      2. measurements

         1. group Id

            BG000

            value

            1

         2. group Id

            BG001

            value

            1

         3. group Id

            BG002

            value

            5

         4. group Id

            BG003

            value

            10

         5. group Id

            BG004

            value

            17

         6. group Id

            BG005

            value

            13

         7. group Id

            BG006

            value

            4

         8. group Id

            BG007

            value

            4

         9. group Id

            BG008

            value

            8

         10. group Id

             BG009

             value

             30

         11. group Id

             BG010

             value

             93

         title

         Not Hispanic or Latino

      3. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            0

         6. group Id

            BG005

            value

            0

         7. group Id

            BG006

            value

            0

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            0

         10. group Id

             BG009

             value

             0

         11. group Id

             BG010

             value

             0

         title

         Unknown or Not Reported

   param Type

   COUNT_OF_PARTICIPANTS

   title

   Ethnicity (NIH/OMB)

   unit Of Measure

   Participants

4. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            0

         6. group Id

            BG005

            value

            0

         7. group Id

            BG006

            value

            0

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            0

         10. group Id

             BG009

             value

             0

         11. group Id

             BG010

             value

             0

         title

         American Indian or Alaska Native

      2. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            1

         4. group Id

            BG003

            value

            1

         5. group Id

            BG004

            value

            5

         6. group Id

            BG005

            value

            4

         7. group Id

            BG006

            value

            2

         8. group Id

            BG007

            value

            3

         9. group Id

            BG008

            value

            2

         10. group Id

             BG009

             value

             14

         11. group Id

             BG010

             value

             32

         title

         Asian

      3. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            0

         6. group Id

            BG005

            value

            0

         7. group Id

            BG006

            value

            0

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            0

         10. group Id

             BG009

             value

             0

         11. group Id

             BG010

             value

             0

         title

         Native Hawaiian or Other Pacific Islander

      4. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            0

         6. group Id

            BG005

            value

            1

         7. group Id

            BG006

            value

            0

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            0

         10. group Id

             BG009

             value

             0

         11. group Id

             BG010

             value

             1

         title

         Black or African American

      5. measurements

         1. group Id

            BG000

            value

            1

         2. group Id

            BG001

            value

            1

         3. group Id

            BG002

            value

            4

         4. group Id

            BG003

            value

            9

         5. group Id

            BG004

            value

            11

         6. group Id

            BG005

            value

            8

         7. group Id

            BG006

            value

            3

         8. group Id

            BG007

            value

            1

         9. group Id

            BG008

            value

            4

         10. group Id

             BG009

             value

             16

         11. group Id

             BG010

             value

             58

         title

         White

      6. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            1

         6. group Id

            BG005

            value

            0

         7. group Id

            BG006

            value

            0

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            0

         10. group Id

             BG009

             value

             0

         11. group Id

             BG010

             value

             1

         title

         More than one race

      7. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         4. group Id

            BG003

            value

            0

         5. group Id

            BG004

            value

            0

         6. group Id

            BG005

            value

            0

         7. group Id

            BG006

            value

            0

         8. group Id

            BG007

            value

            0

         9. group Id

            BG008

            value

            2

         10. group Id

             BG009

             value

             1

         11. group Id

             BG010

             value

             3

         title

         Unknown or Not Reported

   param Type

   COUNT_OF_PARTICIPANTS

   title

   Race (NIH/OMB)

   unit Of Measure

   Participants

population Description

Safety population included all participants who received at least 1 dose of TAK-186.

Download exact source JSON → · Snapshot ctgov-results-d643ffaf417bcef6d45eb5e0

Preserved source evidence · Not medical advice