TriangleNCT04731844 · OUTCOME
Response Rate of Curcumin & Piperine Supplementation in Patients on Active Surveillance for Either Early Stage Prostate Cancer or Patients on Observation for MGUS/Low-risk Smoldering Myeloma.
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- COUNT_OF_PARTICIPANTS
- Unit
- Participants
- Interval / dispersion
- Not reported
- Time frame
- From date of enrollment until the date of first documented response assessed up to 12 months
What was measured
To estimate the proportion of participants achieving a disease-specific response following curcumin and piperine supplementation administered at a dose of 2gm/10mg(2 tablets) orally twice daily for up to 12 months. For patients with early-stage prostate cancer, response was defined as ≥50% decrease in prostate-specific antigen (PSA) from baseline, confirmed at least 4 weeks apart. For patients with MGUS or low-risk SMM, response was defined per International Myeloma Working Group (IMWG) criteria as at least a partial response (≥50% reduction in serum M-protein). The overall response rate equals the number of participants achieving disease-specific response divided by total number analyzed.
Analysis population: All enrolled participants
Groups in this outcome
Prostate Cancer
Curcumin plus Piperine at a dose of 2gm/10mg (2 tablets) orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
Smoldering Multiple Myeloma (SMM)
Curcumin plus Piperine at a dose of 2gm/10mg (2 tablets) orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
Monoclonal Gammopathy of Unknown Significance (MGUS)
Curcumin plus Piperine at a dose of 2gm/10mg (2 tablets) orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
| Group | Source count |
|---|---|
| Prostate Cancer | 12 |
| Smoldering Multiple Myeloma (SMM) | 8 |
| Monoclonal Gammopathy of Unknown Significance (MGUS) | 9 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Prostate Cancer | 10 | Not reported | Not reported | Not reported | Not reported |
| Smoldering Multiple Myeloma (SMM) | 7 | Not reported | Not reported | Not reported | Not reported |
| Monoclonal Gammopathy of Unknown Significance (MGUS) | 8 | Not reported | Not reported | Not reported | Not reported |
Complete source fields
- classes
- categories
- measurements
- group Id
- OG000
- value
- 10
- group Id
- OG001
- value
- 7
- group Id
- OG002
- value
- 8
- denoms
- counts
- group Id
- OG000
- value
- 12
- group Id
- OG001
- value
- 8
- group Id
- OG002
- value
- 9
- units
- Participants
- description
- To estimate the proportion of participants achieving a disease-specific response following curcumin and piperine supplementation administered at a dose of 2gm/10mg(2 tablets) orally twice daily for up to 12 months. For patients with early-stage prostate cancer, response was defined as ≥50% decrease in prostate-specific antigen (PSA) from baseline, confirmed at least 4 weeks apart. For patients with MGUS or low-risk SMM, response was defined per International Myeloma Working Group (IMWG) criteria as at least a partial response (≥50% reduction in serum M-protein). The overall response rate equals the number of participants achieving disease-specific response divided by total number analyzed.
- groups
- description
- Curcumin plus Piperine at a dose of 2gm/10mg (2 tablets) orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
- id
- OG000
- title
- Prostate Cancer
- description
- Curcumin plus Piperine at a dose of 2gm/10mg (2 tablets) orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
- id
- OG001
- title
- Smoldering Multiple Myeloma (SMM)
- description
- Curcumin plus Piperine at a dose of 2gm/10mg (2 tablets) orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
- id
- OG002
- title
- Monoclonal Gammopathy of Unknown Significance (MGUS)
- param Type
- COUNT_OF_PARTICIPANTS
- population Description
- All enrolled participants
- reporting Status
- POSTED
- time Frame
- From date of enrollment until the date of first documented response assessed up to 12 months
- title
- Response Rate of Curcumin & Piperine Supplementation in Patients on Active Surveillance for Either Early Stage Prostate Cancer or Patients on Observation for MGUS/Low-risk Smoldering Myeloma.
- type
- PRIMARY
- unit Of Measure
- Participants
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice