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NCT04731844 · ADVERSE EVENTS

Adverse events

Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer · Source last updated 2026-05-12

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Adverse events occurred during the study; they are not necessarily caused by treatment. Serious events are not interchangeable with severe/grade 3–4 events. These safety populations may differ from efficacy populations.

Collection time frame
1 year
Other-event reporting threshold
0%
Participants affected / participants at risk, as reported
Safety groupSerious eventsOther eventsDeaths
Prostate Cancer

Curcumin plus Piperine at a dose of 2gm/10mg orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.

1 / 1210 / 120 / 12
Smoldering Multiple Myeloma (SMM)

Curcumin plus Piperine at a dose of 2gm/10mg orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.

0 / 87 / 80 / 8
Monoclonal Gammopathy of Unknown Significance (MGUS)

Curcumin plus Piperine at a dose of 2gm/10mg orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.

0 / 98 / 90 / 9

Group identifiers: EG000: Prostate Cancer · EG001: Smoldering Multiple Myeloma (SMM) · EG002: Monoclonal Gammopathy of Unknown Significance (MGUS)

Serious adverse events

Event terms and counts are source-reported; expand to read more. A reporting threshold may omit less frequent events.

  1. assessment Type
    NON_SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
      num Events
      1
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
      num Events
      0
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
      num Events
      0
    term
    Esophageal perforation

Other reported adverse events

Event terms and counts are source-reported; expand to read more. A reporting threshold may omit less frequent events.

  1. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      2
      num At Risk
      9
    term
    Abdominal Pain
  2. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      3
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Alanine Aminotransferase increased
  3. assessment Type
    NON_SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      2
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Anemia
  4. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      1
      num At Risk
      9
    term
    Aspartate aminotransferase increased
  5. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Musculoskeletal and connective tissue disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      1
      num At Risk
      9
    term
    Back Pain
  6. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      2
      num At Risk
      9
    term
    constipation
  7. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Creatinine Increased
  8. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      3
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      2
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Diarrhea
  9. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Respiratory, thoracic and mediastinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    dyspnea
  10. assessment Type
    SYSTEMATIC_ASSESSMENT
    notes
    Right lower extremity edema
    organ System
    General disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Edema Limbs
  11. assessment Type
    SYSTEMATIC_ASSESSMENT
    notes
    Thyroid mass of unclear etiology, Goiter
    organ System
    Endocrine disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Endocrine Disorders-Other, specify
  12. assessment Type
    SYSTEMATIC_ASSESSMENT
    notes
    Diplopia
    organ System
    Eye disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Eye Disorders-Other, specify
Complete source fields
event Groups
  1. deaths Num Affected
    0
    deaths Num At Risk
    12
    description
    Curcumin plus Piperine at a dose of 2gm/10mg orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
    id
    EG000
    other Num Affected
    10
    other Num At Risk
    12
    serious Num Affected
    1
    serious Num At Risk
    12
    title
    Prostate Cancer
  2. deaths Num Affected
    0
    deaths Num At Risk
    8
    description
    Curcumin plus Piperine at a dose of 2gm/10mg orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
    id
    EG001
    other Num Affected
    7
    other Num At Risk
    8
    serious Num Affected
    0
    serious Num At Risk
    8
    title
    Smoldering Multiple Myeloma (SMM)
  3. deaths Num Affected
    0
    deaths Num At Risk
    9
    description
    Curcumin plus Piperine at a dose of 2gm/10mg orally BID for 12 months Curcumin plus Piperine: Curcumin with piperine is a well-tolerated over-the-counter supplement.
    id
    EG002
    other Num Affected
    8
    other Num At Risk
    9
    serious Num Affected
    0
    serious Num At Risk
    9
    title
    Monoclonal Gammopathy of Unknown Significance (MGUS)
frequency Threshold
0
other Events
  1. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      2
      num At Risk
      9
    term
    Abdominal Pain
  2. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      3
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Alanine Aminotransferase increased
  3. assessment Type
    NON_SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      2
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Anemia
  4. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      1
      num At Risk
      9
    term
    Aspartate aminotransferase increased
  5. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Musculoskeletal and connective tissue disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      1
      num At Risk
      9
    term
    Back Pain
  6. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      2
      num At Risk
      9
    term
    constipation
  7. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Creatinine Increased
  8. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      3
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      2
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Diarrhea
  9. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Respiratory, thoracic and mediastinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    dyspnea
  10. assessment Type
    SYSTEMATIC_ASSESSMENT
    notes
    Right lower extremity edema
    organ System
    General disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Edema Limbs
  11. assessment Type
    SYSTEMATIC_ASSESSMENT
    notes
    Thyroid mass of unclear etiology, Goiter
    organ System
    Endocrine disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Endocrine Disorders-Other, specify
  12. assessment Type
    SYSTEMATIC_ASSESSMENT
    notes
    Diplopia
    organ System
    Eye disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
    term
    Eye Disorders-Other, specify
serious Events
  1. assessment Type
    NON_SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE 5.0
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      12
      num Events
      1
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      8
      num Events
      0
    3. group Id
      EG002
      num Affected
      0
      num At Risk
      9
      num Events
      0
    term
    Esophageal perforation
time Frame
1 year

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Preserved source evidence · Not medical advice