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NCT04106492 · FLOW

Participant flow

Phase 1/2a Study of SQ3370 in Patients With Advanced Solid Tumors · Source last updated 2025-11-14

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups
  1. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 8 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG000
    title
    Dose Escalation Cohort 1 (10 mL SQL70 and 8 mg/m^2 of SQP33)
  2. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 16 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG001
    title
    Dose Escalation Cohort 2 (10 mL SQL70 and 16 mg/m^2 of SQP33)
  3. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 32 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG002
    title
    Dose Escalation Cohort 3 (10 mL SQL70 and 32 mg/m^2 of SQP33)
  4. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 58 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG003
    title
    Dose Escalation Cohort 4 (10 mL SQL70 and 58 mg/m^2 of SQP33)
  5. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 85 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG004
    title
    Dose Escalation Cohort 5 (10 mL SQL70 and 85 mg/m^2 of SQP33)
  6. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 125 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG005
    title
    Dose Escalation Cohort 6 (10 mL SQL70 and 125 mg/m^2 of SQP33)
  7. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 185 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG006
    title
    Dose Escalation Cohort 7 (10 mL SQL70 and 185 mg/m^2 of SQP33)
  8. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 250 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG007
    title
    Dose Escalation Cohort 8 (10 mL SQL70 and 250 mg/m^2 of SQP33)
  9. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 315 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG008
    title
    Dose Escalation Cohort 9 (10 mL SQL70 and 315 mg/m^2 of SQP33)
  10. description
    20 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 85 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG009
    title
    Dose Escalation Cohort (20 mL SQL70 and 85 mg/m^2 of SQP33)
  11. description
    20 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 125 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG010
    title
    Dose Escalation Cohort (20 mL SQL70 and 125 mg/m^2 of SQP33)
  12. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 185 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG011
    title
    Cohort A (10 mL SQL70 and 185 mg/m^2 of SQP33)
periods
  1. milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        1
      2. group Id
        FG001
        num Subjects
        1
      3. group Id
        FG002
        num Subjects
        1
      4. group Id
        FG003
        num Subjects
        3
      5. group Id
        FG004
        num Subjects
        3
      6. group Id
        FG005
        num Subjects
        4
      7. group Id
        FG006
        num Subjects
        4
      8. group Id
        FG007
        num Subjects
        7
      9. group Id
        FG008
        num Subjects
        6
      10. group Id
        FG009
        num Subjects
        5
      11. group Id
        FG010
        num Subjects
        3
      12. group Id
        FG011
        num Subjects
        1
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        1
      2. group Id
        FG001
        num Subjects
        1
      3. group Id
        FG002
        num Subjects
        1
      4. group Id
        FG003
        num Subjects
        3
      5. group Id
        FG004
        num Subjects
        3
      6. group Id
        FG005
        num Subjects
        4
      7. group Id
        FG006
        num Subjects
        4
      8. group Id
        FG007
        num Subjects
        7
      9. group Id
        FG008
        num Subjects
        6
      10. group Id
        FG009
        num Subjects
        5
      11. group Id
        FG010
        num Subjects
        3
      12. group Id
        FG011
        num Subjects
        1
      type
      COMPLETED
    3. achievements
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        0
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        0
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      9. group Id
        FG008
        num Subjects
        0
      10. group Id
        FG009
        num Subjects
        0
      11. group Id
        FG010
        num Subjects
        0
      12. group Id
        FG011
        num Subjects
        0
      type
      NOT COMPLETED
    title
    Overall Study
Complete source fields
groups
  1. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 8 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG000
    title
    Dose Escalation Cohort 1 (10 mL SQL70 and 8 mg/m^2 of SQP33)
  2. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 16 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG001
    title
    Dose Escalation Cohort 2 (10 mL SQL70 and 16 mg/m^2 of SQP33)
  3. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 32 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG002
    title
    Dose Escalation Cohort 3 (10 mL SQL70 and 32 mg/m^2 of SQP33)
  4. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 58 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG003
    title
    Dose Escalation Cohort 4 (10 mL SQL70 and 58 mg/m^2 of SQP33)
  5. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 85 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG004
    title
    Dose Escalation Cohort 5 (10 mL SQL70 and 85 mg/m^2 of SQP33)
  6. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 125 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG005
    title
    Dose Escalation Cohort 6 (10 mL SQL70 and 125 mg/m^2 of SQP33)
  7. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 185 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG006
    title
    Dose Escalation Cohort 7 (10 mL SQL70 and 185 mg/m^2 of SQP33)
  8. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 250 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG007
    title
    Dose Escalation Cohort 8 (10 mL SQL70 and 250 mg/m^2 of SQP33)
  9. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 315 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG008
    title
    Dose Escalation Cohort 9 (10 mL SQL70 and 315 mg/m^2 of SQP33)
  10. description
    20 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 85 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG009
    title
    Dose Escalation Cohort (20 mL SQL70 and 85 mg/m^2 of SQP33)
  11. description
    20 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 125 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG010
    title
    Dose Escalation Cohort (20 mL SQL70 and 125 mg/m^2 of SQP33)
  12. description
    10 mL of SQL70 injected intratumorally on Day 1 of each 21-day cycle into a single lesion with 185 mg/m\^2 of SQP33 infused each day on Day 1 through Day 5 in subjects with locally advanced or metastatic solid tumors
    id
    FG011
    title
    Cohort A (10 mL SQL70 and 185 mg/m^2 of SQP33)
periods
  1. milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        1
      2. group Id
        FG001
        num Subjects
        1
      3. group Id
        FG002
        num Subjects
        1
      4. group Id
        FG003
        num Subjects
        3
      5. group Id
        FG004
        num Subjects
        3
      6. group Id
        FG005
        num Subjects
        4
      7. group Id
        FG006
        num Subjects
        4
      8. group Id
        FG007
        num Subjects
        7
      9. group Id
        FG008
        num Subjects
        6
      10. group Id
        FG009
        num Subjects
        5
      11. group Id
        FG010
        num Subjects
        3
      12. group Id
        FG011
        num Subjects
        1
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        1
      2. group Id
        FG001
        num Subjects
        1
      3. group Id
        FG002
        num Subjects
        1
      4. group Id
        FG003
        num Subjects
        3
      5. group Id
        FG004
        num Subjects
        3
      6. group Id
        FG005
        num Subjects
        4
      7. group Id
        FG006
        num Subjects
        4
      8. group Id
        FG007
        num Subjects
        7
      9. group Id
        FG008
        num Subjects
        6
      10. group Id
        FG009
        num Subjects
        5
      11. group Id
        FG010
        num Subjects
        3
      12. group Id
        FG011
        num Subjects
        1
      type
      COMPLETED
    3. achievements
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        0
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        0
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      9. group Id
        FG008
        num Subjects
        0
      10. group Id
        FG009
        num Subjects
        0
      11. group Id
        FG010
        num Subjects
        0
      12. group Id
        FG011
        num Subjects
        0
      type
      NOT COMPLETED
    title
    Overall Study

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice