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NCT04030455 · OUTCOME

Larynx Preservation Rates for Overall and pCR Patients at 2 Years

Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With Stage II-III Laryngeal Cancer · Source last updated 2026-03-09

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
proportion of participants
Interval / dispersion
95% Confidence Interval
Time frame
study registration to laryngectomy or date of censoring (2 years follow up)

What was measured

To determine the laryngeal preservation rate (LPR) at 2 years in the overall population and in the subgroup who achieves a pCR. KM method was used. The larynx preservation rate is calculated by dividing the number of patients who did not need a laryngectomy (either total or partial) after initial treatment by the total number of patients who were candidates for such a treatment.

Groups in this outcome

Experimental (Cis/Doce/Pembro)

cis 75 mg/m2 (SOC), doce 74 mg/m2 (SOC), pembro 200mg (Exp), Q3W IV

PCR Participants

Out of the experimental group these subjects had pathological complete response

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Experimental (Cis/Doce/Pembro)24
PCR Participants19

Reported measurements

Source class 1
Values in proportion of participants · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Experimental (Cis/Doce/Pembro)0.83Not reported0.670.98Not reported
PCR Participants0.94Not reported0.841.05Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        0.67
        upper Limit
        0.98
        value
        0.83
      2. group Id
        OG001
        lower Limit
        0.84
        upper Limit
        1.05
        value
        0.94
denoms
  1. counts
    1. group Id
      OG000
      value
      24
    2. group Id
      OG001
      value
      19
    units
    Participants
description
To determine the laryngeal preservation rate (LPR) at 2 years in the overall population and in the subgroup who achieves a pCR. KM method was used. The larynx preservation rate is calculated by dividing the number of patients who did not need a laryngectomy (either total or partial) after initial treatment by the total number of patients who were candidates for such a treatment.
dispersion Type
95% Confidence Interval
groups
  1. description
    cis 75 mg/m2 (SOC), doce 74 mg/m2 (SOC), pembro 200mg (Exp), Q3W IV
    id
    OG000
    title
    Experimental (Cis/Doce/Pembro)
  2. description
    Out of the experimental group these subjects had pathological complete response
    id
    OG001
    title
    PCR Participants
param Type
NUMBER
reporting Status
POSTED
time Frame
study registration to laryngectomy or date of censoring (2 years follow up)
title
Larynx Preservation Rates for Overall and pCR Patients at 2 Years
type
SECONDARY
unit Of Measure
proportion of participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice