TriangleNCT03894618 · OUTCOME
Terminal Half Life (t1/2)
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEDIAN
- Unit
- hours
- Interval / dispersion
- Full Range
- Time frame
- Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (cycle = 28 days)
What was measured
The t1/2 elimination half-life of SL-279252
Analysis population: PK Population - number analyzed may be less than the number of participants in a given cohort if samples were below the limit of quantitation or not available for analysis. Not estimable based on subjects' concentration profiles, including values below the limit of quantification
Groups in this outcome
SL-279252 (0.0001 mg/kg S1)
0.0001 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (0.001 mg/kg S1)
0.001 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (0.003 mg/kg S1)
0.003 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (0.01 mg/kg S1)
0.01 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (0.03 mg/kg S1)
0.03 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (0.1 mg/kg S1)
0.1 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (0.3 mg/kg S1 or S2)
0.3 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)
SL-279252 (1.0 mg/kg S1 or S2)
1.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)
SL-279252 (3.0 mg/kg S1 or S2)
3.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)
SL-279252 (6.0 mg/kg S1)
6.0 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (12.0 mg/kg S1)
12.0 mg/kg of IV SL-279252 (Schedule 1)
SL-279252 (24.0 mg/kg S1)
24.0 mg/kg of IV SL-279252 (Schedule 1)
| Group | Source count |
|---|---|
| SL-279252 (0.0001 mg/kg S1) | 1 |
| SL-279252 (0.001 mg/kg S1) | 1 |
| SL-279252 (0.003 mg/kg S1) | 2 |
| SL-279252 (0.01 mg/kg S1) | 1 |
| SL-279252 (0.03 mg/kg S1) | 2 |
| SL-279252 (0.1 mg/kg S1) | 3 |
| SL-279252 (0.3 mg/kg S1 or S2) | 8 |
| SL-279252 (1.0 mg/kg S1 or S2) | 12 |
| SL-279252 (3.0 mg/kg S1 or S2) | 9 |
| SL-279252 (6.0 mg/kg S1) | 4 |
| SL-279252 (12.0 mg/kg S1) | 4 |
| SL-279252 (24.0 mg/kg S1) | 2 |
Reported measurements
Cycle 1 Day 1
| Group | Source count |
|---|---|
| SL-279252 (0.0001 mg/kg S1) | 1 |
| SL-279252 (0.001 mg/kg S1) | 1 |
| SL-279252 (0.003 mg/kg S1) | 2 |
| SL-279252 (0.01 mg/kg S1) | 1 |
| SL-279252 (0.03 mg/kg S1) | 2 |
| SL-279252 (0.1 mg/kg S1) | 3 |
| SL-279252 (0.3 mg/kg S1 or S2) | 8 |
| SL-279252 (1.0 mg/kg S1 or S2) | 12 |
| SL-279252 (3.0 mg/kg S1 or S2) | 9 |
| SL-279252 (6.0 mg/kg S1) | 4 |
| SL-279252 (12.0 mg/kg S1) | 4 |
| SL-279252 (24.0 mg/kg S1) | 2 |
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| SL-279252 (0.0001 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.001 mg/kg S1) | 2.69 | Not reported | 2.69 | 2.69 | Not reported |
| SL-279252 (0.003 mg/kg S1) | 4.36 | Not reported | 2.23 | 6.49 | Not reported |
| SL-279252 (0.01 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.03 mg/kg S1) | 1.23 | Not reported | 1.23 | 1.23 | Not reported |
| SL-279252 (0.1 mg/kg S1) | 25.2 | Not reported | 2.49 | 26.3 | Not reported |
| SL-279252 (0.3 mg/kg S1 or S2) | 23.4 | Not reported | 17.0 | 29.1 | Not reported |
| SL-279252 (1.0 mg/kg S1 or S2) | 22.6 | Not reported | 15.3 | 24.9 | Not reported |
| SL-279252 (3.0 mg/kg S1 or S2) | 22.4 | Not reported | 19.4 | 36.3 | Not reported |
| SL-279252 (6.0 mg/kg S1) | 22.9 | Not reported | 19.1 | 27.3 | Not reported |
| SL-279252 (12.0 mg/kg S1) | 20.0 | Not reported | 12.9 | 22.4 | Not reported |
| SL-279252 (24.0 mg/kg S1) | 14.4 | Not reported | 10.5 | 18.3 | Not reported |
Cycle 1 Day 15
| Group | Source count |
|---|---|
| SL-279252 (0.0001 mg/kg S1) | 1 |
| SL-279252 (0.001 mg/kg S1) | 1 |
| SL-279252 (0.003 mg/kg S1) | 1 |
| SL-279252 (0.01 mg/kg S1) | 1 |
| SL-279252 (0.03 mg/kg S1) | 2 |
| SL-279252 (0.1 mg/kg S1) | 3 |
| SL-279252 (0.3 mg/kg S1 or S2) | 7 |
| SL-279252 (1.0 mg/kg S1 or S2) | 12 |
| SL-279252 (3.0 mg/kg S1 or S2) | 9 |
| SL-279252 (6.0 mg/kg S1) | 3 |
| SL-279252 (12.0 mg/kg S1) | 4 |
| SL-279252 (24.0 mg/kg S1) | 2 |
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| SL-279252 (0.0001 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.001 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.003 mg/kg S1) | 5.74 | Not reported | 5.74 | 5.74 | Not reported |
| SL-279252 (0.01 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.03 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.1 mg/kg S1) | 5.30 | Not reported | 5.17 | 5.43 | Not reported |
| SL-279252 (0.3 mg/kg S1 or S2) | 5.87 | Not reported | 4.86 | 6.95 | Not reported |
| SL-279252 (1.0 mg/kg S1 or S2) | 6.00 | Not reported | 3.06 | 7.05 | Not reported |
| SL-279252 (3.0 mg/kg S1 or S2) | 6.14 | Not reported | 5.34 | 7.01 | Not reported |
| SL-279252 (6.0 mg/kg S1) | 6.48 | Not reported | 5.73 | 7.31 | Not reported |
| SL-279252 (12.0 mg/kg S1) | 4.86 | Not reported | 4.82 | 5.60 | Not reported |
| SL-279252 (24.0 mg/kg S1) | 4.13 | Not reported | 3.99 | 4.26 | Not reported |
Cycle 2 Day 1 (Schedule 1 only)
| Group | Source count |
|---|---|
| SL-279252 (0.0001 mg/kg S1) | 1 |
| SL-279252 (0.001 mg/kg S1) | 1 |
| SL-279252 (0.003 mg/kg S1) | 2 |
| SL-279252 (0.01 mg/kg S1) | 0 |
| SL-279252 (0.03 mg/kg S1) | 2 |
| SL-279252 (0.1 mg/kg S1) | 3 |
| SL-279252 (0.3 mg/kg S1 or S2) | 4 |
| SL-279252 (1.0 mg/kg S1 or S2) | 5 |
| SL-279252 (3.0 mg/kg S1 or S2) | 5 |
| SL-279252 (6.0 mg/kg S1) | 2 |
| SL-279252 (12.0 mg/kg S1) | 4 |
| SL-279252 (24.0 mg/kg S1) | 2 |
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| SL-279252 (0.0001 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.001 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.003 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.03 mg/kg S1) | NA | Not reported | NA | NA | Not estimable based on subjects' concentration profiles, including values below the limit of quantification |
| SL-279252 (0.1 mg/kg S1) | 5.30 | Not reported | 3.10 | 5.51 | Not reported |
| SL-279252 (0.3 mg/kg S1 or S2) | 5.22 | Not reported | 4.46 | 5.90 | Not reported |
| SL-279252 (1.0 mg/kg S1 or S2) | 5.98 | Not reported | 5.70 | 6.56 | Not reported |
| SL-279252 (3.0 mg/kg S1 or S2) | 5.48 | Not reported | 5.09 | 5.88 | Not reported |
| SL-279252 (6.0 mg/kg S1) | 5.32 | Not reported | 4.64 | 6.00 | Not reported |
| SL-279252 (12.0 mg/kg S1) | 4.71 | Not reported | 4.62 | 5.44 | Not reported |
| SL-279252 (24.0 mg/kg S1) | 3.78 | Not reported | 3.34 | 4.23 | Not reported |
Cycle 2 Day 1 (Schedule 2 only)
| Group | Source count |
|---|---|
| SL-279252 (0.0001 mg/kg S1) | 0 |
| SL-279252 (0.001 mg/kg S1) | 0 |
| SL-279252 (0.003 mg/kg S1) | 0 |
| SL-279252 (0.01 mg/kg S1) | 0 |
| SL-279252 (0.03 mg/kg S1) | 0 |
| SL-279252 (0.1 mg/kg S1) | 0 |
| SL-279252 (0.3 mg/kg S1 or S2) | 3 |
| SL-279252 (1.0 mg/kg S1 or S2) | 6 |
| SL-279252 (3.0 mg/kg S1 or S2) | 3 |
| SL-279252 (6.0 mg/kg S1) | 0 |
| SL-279252 (12.0 mg/kg S1) | 0 |
| SL-279252 (24.0 mg/kg S1) | 0 |
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| SL-279252 (0.3 mg/kg S1 or S2) | 4.48 | Not reported | 4.31 | 5.50 | Not reported |
| SL-279252 (1.0 mg/kg S1 or S2) | 5.09 | Not reported | 2.33 | 5.80 | Not reported |
| SL-279252 (3.0 mg/kg S1 or S2) | 5.10 | Not reported | 4.18 | 5.79 | Not reported |
Complete source fields
- classes
- categories
- measurements
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG000
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- group Id
- OG001
- lower Limit
- 2.69
- upper Limit
- 2.69
- value
- 2.69
- group Id
- OG002
- lower Limit
- 2.23
- upper Limit
- 6.49
- value
- 4.36
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG003
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- group Id
- OG004
- lower Limit
- 1.23
- upper Limit
- 1.23
- value
- 1.23
- group Id
- OG005
- lower Limit
- 2.49
- upper Limit
- 26.3
- value
- 25.2
- group Id
- OG006
- lower Limit
- 17.0
- upper Limit
- 29.1
- value
- 23.4
- group Id
- OG007
- lower Limit
- 15.3
- upper Limit
- 24.9
- value
- 22.6
- group Id
- OG008
- lower Limit
- 19.4
- upper Limit
- 36.3
- value
- 22.4
- group Id
- OG009
- lower Limit
- 19.1
- upper Limit
- 27.3
- value
- 22.9
- group Id
- OG010
- lower Limit
- 12.9
- upper Limit
- 22.4
- value
- 20.0
- group Id
- OG011
- lower Limit
- 10.5
- upper Limit
- 18.3
- value
- 14.4
- denoms
- counts
- group Id
- OG000
- value
- 1
- group Id
- OG001
- value
- 1
- group Id
- OG002
- value
- 2
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 2
- group Id
- OG005
- value
- 3
- group Id
- OG006
- value
- 8
- group Id
- OG007
- value
- 12
- group Id
- OG008
- value
- 9
- group Id
- OG009
- value
- 4
- group Id
- OG010
- value
- 4
- group Id
- OG011
- value
- 2
- units
- Participants
- title
- Cycle 1 Day 1
- categories
- measurements
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG000
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG001
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- group Id
- OG002
- lower Limit
- 5.74
- upper Limit
- 5.74
- value
- 5.74
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG003
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG004
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- group Id
- OG005
- lower Limit
- 5.17
- upper Limit
- 5.43
- value
- 5.30
- group Id
- OG006
- lower Limit
- 4.86
- upper Limit
- 6.95
- value
- 5.87
- group Id
- OG007
- lower Limit
- 3.06
- upper Limit
- 7.05
- value
- 6.00
- group Id
- OG008
- lower Limit
- 5.34
- upper Limit
- 7.01
- value
- 6.14
- group Id
- OG009
- lower Limit
- 5.73
- upper Limit
- 7.31
- value
- 6.48
- group Id
- OG010
- lower Limit
- 4.82
- upper Limit
- 5.60
- value
- 4.86
- group Id
- OG011
- lower Limit
- 3.99
- upper Limit
- 4.26
- value
- 4.13
- denoms
- counts
- group Id
- OG000
- value
- 1
- group Id
- OG001
- value
- 1
- group Id
- OG002
- value
- 1
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 2
- group Id
- OG005
- value
- 3
- group Id
- OG006
- value
- 7
- group Id
- OG007
- value
- 12
- group Id
- OG008
- value
- 9
- group Id
- OG009
- value
- 3
- group Id
- OG010
- value
- 4
- group Id
- OG011
- value
- 2
- units
- Participants
- title
- Cycle 1 Day 15
- categories
- measurements
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG000
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG001
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG002
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- comment
- Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- group Id
- OG004
- lower Limit
- NA
- upper Limit
- NA
- value
- NA
- group Id
- OG005
- lower Limit
- 3.10
- upper Limit
- 5.51
- value
- 5.30
- group Id
- OG006
- lower Limit
- 4.46
- upper Limit
- 5.90
- value
- 5.22
- group Id
- OG007
- lower Limit
- 5.70
- upper Limit
- 6.56
- value
- 5.98
- group Id
- OG008
- lower Limit
- 5.09
- upper Limit
- 5.88
- value
- 5.48
- group Id
- OG009
- lower Limit
- 4.64
- upper Limit
- 6.00
- value
- 5.32
- group Id
- OG010
- lower Limit
- 4.62
- upper Limit
- 5.44
- value
- 4.71
- group Id
- OG011
- lower Limit
- 3.34
- upper Limit
- 4.23
- value
- 3.78
- denoms
- counts
- group Id
- OG000
- value
- 1
- group Id
- OG001
- value
- 1
- group Id
- OG002
- value
- 2
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 2
- group Id
- OG005
- value
- 3
- group Id
- OG006
- value
- 4
- group Id
- OG007
- value
- 5
- group Id
- OG008
- value
- 5
- group Id
- OG009
- value
- 2
- group Id
- OG010
- value
- 4
- group Id
- OG011
- value
- 2
- units
- Participants
- title
- Cycle 2 Day 1 (Schedule 1 only)
- categories
- measurements
- group Id
- OG006
- lower Limit
- 4.31
- upper Limit
- 5.50
- value
- 4.48
- group Id
- OG007
- lower Limit
- 2.33
- upper Limit
- 5.80
- value
- 5.09
- group Id
- OG008
- lower Limit
- 4.18
- upper Limit
- 5.79
- value
- 5.10
- denoms
- counts
- group Id
- OG000
- value
- 0
- group Id
- OG001
- value
- 0
- group Id
- OG002
- value
- 0
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 0
- group Id
- OG005
- value
- 0
- group Id
- OG006
- value
- 3
- group Id
- OG007
- value
- 6
- group Id
- OG008
- value
- 3
- group Id
- OG009
- value
- 0
- group Id
- OG010
- value
- 0
- group Id
- OG011
- value
- 0
- units
- Participants
- title
- Cycle 2 Day 1 (Schedule 2 only)
- denoms
- counts
- group Id
- OG000
- value
- 1
- group Id
- OG001
- value
- 1
- group Id
- OG002
- value
- 2
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 2
- group Id
- OG005
- value
- 3
- group Id
- OG006
- value
- 8
- group Id
- OG007
- value
- 12
- group Id
- OG008
- value
- 9
- group Id
- OG009
- value
- 4
- group Id
- OG010
- value
- 4
- group Id
- OG011
- value
- 2
- units
- Participants
- description
- The t1/2 elimination half-life of SL-279252
- dispersion Type
- Full Range
- groups
- description
- 0.0001 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG000
- title
- SL-279252 (0.0001 mg/kg S1)
- description
- 0.001 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG001
- title
- SL-279252 (0.001 mg/kg S1)
- description
- 0.003 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG002
- title
- SL-279252 (0.003 mg/kg S1)
- description
- 0.01 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG003
- title
- SL-279252 (0.01 mg/kg S1)
- description
- 0.03 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG004
- title
- SL-279252 (0.03 mg/kg S1)
- description
- 0.1 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG005
- title
- SL-279252 (0.1 mg/kg S1)
- description
- 0.3 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)
- id
- OG006
- title
- SL-279252 (0.3 mg/kg S1 or S2)
- description
- 1.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)
- id
- OG007
- title
- SL-279252 (1.0 mg/kg S1 or S2)
- description
- 3.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)
- id
- OG008
- title
- SL-279252 (3.0 mg/kg S1 or S2)
- description
- 6.0 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG009
- title
- SL-279252 (6.0 mg/kg S1)
- description
- 12.0 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG010
- title
- SL-279252 (12.0 mg/kg S1)
- description
- 24.0 mg/kg of IV SL-279252 (Schedule 1)
- id
- OG011
- title
- SL-279252 (24.0 mg/kg S1)
- param Type
- MEDIAN
- population Description
- PK Population - number analyzed may be less than the number of participants in a given cohort if samples were below the limit of quantitation or not available for analysis. Not estimable based on subjects' concentration profiles, including values below the limit of quantification
- reporting Status
- POSTED
- time Frame
- Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (cycle = 28 days)
- title
- Terminal Half Life (t1/2)
- type
- SECONDARY
- unit Of Measure
- hours
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Preserved source evidence · Not medical advice