NCT03894618 · OUTCOME

Immunogenicity to SL-279252

SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas · Source last updated 2025-04-02

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: COUNT_OF_PARTICIPANTS
Unit: Participants
Interval / dispersion: Not reported
Time frame: Approximately 32 months

What was measured

Number of participants with positive anti-drug antibody (ADA) titer, of those who were ADA negative at baseline

Analysis population: For arms 0.0001 and 0.001 mg/kg of IV SL-279252, there were no subjects who were ADA negative at baseline. For arms 12.0 and 24.0 mg/kg of IV SL-279252, ADA samples were not collected.

Groups in this outcome

SL-279252 (0.0001 mg/kg S1)

0.0001 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.001 mg/kg S1)

0.001 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.003 mg/kg S1)

0.003 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.01 mg/kg S1)

0.01 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.03 mg/kg S1)

0.03 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.1 mg/kg S1)

0.1 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.3 mg/kg S1)

0.3 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (1.0 mg/kg S1)

1.0 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (3.0 mg/kg S1)

3.0 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (6.0 mg/kg S1)

6.0 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (12.0 mg/kg S1)

12.0 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (24.0 mg/kg S1)

24.0 mg/kg of IV SL-279252 (Schedule 1)

SL-279252 (0.3 mg/kg S2)

0.3 mg/kg of IV SL-279252 (Schedule 2)

SL-279252 (1.0 mg/kg S2)

1.0 mg/kg of IV SL-279252 (Schedule 2)

SL-279252 (3.0 mg/kg S2)

3.0 mg/kg of IV SL-279252 (Schedule 2)

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
SL-279252 (0.0001 mg/kg S1)	0
SL-279252 (0.001 mg/kg S1)	0
SL-279252 (0.003 mg/kg S1)	1
SL-279252 (0.01 mg/kg S1)	1
SL-279252 (0.03 mg/kg S1)	2
SL-279252 (0.1 mg/kg S1)	2
SL-279252 (0.3 mg/kg S1)	3
SL-279252 (1.0 mg/kg S1)	5
SL-279252 (3.0 mg/kg S1)	4
SL-279252 (6.0 mg/kg S1)	3
SL-279252 (12.0 mg/kg S1)	0
SL-279252 (24.0 mg/kg S1)	0
SL-279252 (0.3 mg/kg S2)	2
SL-279252 (1.0 mg/kg S2)	5
SL-279252 (3.0 mg/kg S2)	3

Reported measurements

Source class 1

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SL-279252 (0.0001 mg/kg S1)	0	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.001 mg/kg S1)	0	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.003 mg/kg S1)	0	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.01 mg/kg S1)	1	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.03 mg/kg S1)	1	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.1 mg/kg S1)	2	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.3 mg/kg S1)	1	Not reported	Not reported	Not reported	Not reported
SL-279252 (1.0 mg/kg S1)	1	Not reported	Not reported	Not reported	Not reported
SL-279252 (3.0 mg/kg S1)	3	Not reported	Not reported	Not reported	Not reported
SL-279252 (6.0 mg/kg S1)	1	Not reported	Not reported	Not reported	Not reported
SL-279252 (12.0 mg/kg S1)	0	Not reported	Not reported	Not reported	Not reported
SL-279252 (24.0 mg/kg S1)	0	Not reported	Not reported	Not reported	Not reported
SL-279252 (0.3 mg/kg S2)	1	Not reported	Not reported	Not reported	Not reported
SL-279252 (1.0 mg/kg S2)	3	Not reported	Not reported	Not reported	Not reported
SL-279252 (3.0 mg/kg S2)	3	Not reported	Not reported	Not reported	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
1
group Id
OG004
value
1
group Id
OG005
value
2
group Id
OG006
value
1
group Id
OG007
value
1
group Id
OG008
value
3
group Id
OG009
value
1
group Id
OG010
value
0
group Id
OG011
value
0

denoms

counts
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
1
group Id
OG003
value
1
group Id
OG004
value
2
group Id
OG005
value
2
group Id
OG006
value
3
group Id
OG007
value
5
group Id
OG008
value
4
group Id
OG009
value
3
group Id
OG010
value
0
group Id
OG011
value
0
units
Participants

description

Number of participants with positive anti-drug antibody (ADA) titer, of those who were ADA negative at baseline

groups

description
0.0001 mg/kg of IV SL-279252 (Schedule 1)
id
OG000
title
SL-279252 (0.0001 mg/kg S1)
description
0.001 mg/kg of IV SL-279252 (Schedule 1)
id
OG001
title
SL-279252 (0.001 mg/kg S1)
description
0.003 mg/kg of IV SL-279252 (Schedule 1)
id
OG002
title
SL-279252 (0.003 mg/kg S1)
description
0.01 mg/kg of IV SL-279252 (Schedule 1)
id
OG003
title
SL-279252 (0.01 mg/kg S1)
description
0.03 mg/kg of IV SL-279252 (Schedule 1)
id
OG004
title
SL-279252 (0.03 mg/kg S1)
description
0.1 mg/kg of IV SL-279252 (Schedule 1)
id
OG005
title
SL-279252 (0.1 mg/kg S1)
description
0.3 mg/kg of IV SL-279252 (Schedule 1)
id
OG006
title
SL-279252 (0.3 mg/kg S1)
description
1.0 mg/kg of IV SL-279252 (Schedule 1)
id
OG007
title
SL-279252 (1.0 mg/kg S1)
description
3.0 mg/kg of IV SL-279252 (Schedule 1)
id
OG008
title
SL-279252 (3.0 mg/kg S1)
description
6.0 mg/kg of IV SL-279252 (Schedule 1)
id
OG009
title
SL-279252 (6.0 mg/kg S1)
description
12.0 mg/kg of IV SL-279252 (Schedule 1)
id
OG010
title
SL-279252 (12.0 mg/kg S1)
description
24.0 mg/kg of IV SL-279252 (Schedule 1)
id
OG011
title
SL-279252 (24.0 mg/kg S1)

param Type

COUNT_OF_PARTICIPANTS

population Description

For arms 0.0001 and 0.001 mg/kg of IV SL-279252, there were no subjects who were ADA negative at baseline. For arms 12.0 and 24.0 mg/kg of IV SL-279252, ADA samples were not collected.

reporting Status

POSTED

time Frame

Approximately 32 months

title

Immunogenicity to SL-279252

type

SECONDARY

unit Of Measure

Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice