Skip to content
Triangle logo TriangleGet started
← Study library

NCT03805971 · REGISTRY CONDITION SEARCH

Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Malignancies Diagnosis.

Found through the registry condition index, not selected as a treatment recommendation. This discovery collection was restricted to studies with posted results.

Phase
Not reported
Status at capture
COMPLETED
Registry last update
2020-04-03

Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies"). It was first used in gastroenterology and came later to the light in pulmonary medicine and is still an experimental technique. In gastroenterology, this new investigational technique is used in Barret oesophagus, inflammatory bowel disease, pancreas cystic lesions... Nowadays, there are no data concerning usefulness of endomicroscopy in medical thoracoscopy. During thoracoscopy This new tool could help to target biopsies or help clinicians to do the right diagnosis early, allowing rapid therapeutic intervention (talc pleurodesis for example) . Furthermore, some details can be studied only during live imaging as microorganisms or bloodflows. The investigators performed an endomicroscopy to every patient needing a thoracoscopy (no matter the indication) and who agreed to participate. The pCLE features between malignant and benign pleura were compared in order to find specific criteria for malignant infiltration.

Open the original ClinicalTrials.gov record → · Download preserved record

What did the study report?

Outcomes, safety and baseline populations are separate source sections. Quality-of-life measures appear under their original outcome titles.

flow

Participant flow

→

baseline

Baseline characteristics

→

outcome · POSTED

Pleural Carcinomatosis Identification (Compared to Standard Biopsies). Qualitative Criteria.

→

outcome · POSTED

Pleural Carcinomatosis Identification (Compared to Standard Biopsies), Quantitative Criteria.

→

outcome · POSTED

Quality of the pCLE Acquisition

→

outcome · POSTED

Pleural Carcinomatosis Identification (Compared to Standard Biopsies), Quantitative Criteria.

→

outcome · POSTED

Pleural Carcinomatosis Identification (Compared to Standard Biopsies), Quantitative Criteria.

→

adverse events

Adverse events

→

more info

Limitations, agreements, and source contact

→
Who could take part
eligibility Criteria
Inclusion Criteria: * Every patient refered for a medical thoracoscopy and willing to participate. Exclusion Criteria: * \< 18 ans
healthy Volunteers
false
minimum Age
18 Years
sampling Method
NON_PROBABILITY_SAMPLE
sex
ALL
std Ages
  1. ADULT
  2. OLDER_ADULT
study Population
Every patient refered for a medical thoracoscopy and willing to participate.
Treatment arms and interventions
arm Groups
  1. description
    Probe based confocal laser endomicroscopy (Mauna kea technologies) will be used, after intravenous fluorescein injection, for every patients admitted for medical thoracoscopy, to study the pleural cavity. Images will be compared with biopsies
    intervention Names
    1. Device: Study of the pleural cavity with a confocal laser endomicroscope.
    label
    patient aged more than 18 years admitted for thoracoscopy
interventions
  1. arm Group Labels
    1. patient aged more than 18 years admitted for thoracoscopy
    description
    Probe based confocal laser endomicroscope can be introduced through the working chanel of the thoracoscope. this allows the study of the pleural cavity with this new tool.
    name
    Study of the pleural cavity with a confocal laser endomicroscope.
    type
    DEVICE
Study design
observational Model
CASE_ONLY
time Perspective
PROSPECTIVE
Enrollment
count
65
type
ACTUAL
Registered outcome plans (not posted results)
primary Outcomes
  1. description
    Eleven preselected criteria were assessed in their ability to distinguish benign from malignant pleura Qualitative variables are presented in this table
    measure
    Pleural Carcinomatosis Identification (Compared to Standard Biopsies). Qualitative Criteria.
    time Frame
    One day.
  2. description
    Eleven preselected pCLE criteria were assessed in their ability to distinguish benign from malignant pleura. Here are presented Mean cell size and maximum vascular diameter
    measure
    Pleural Carcinomatosis Identification (Compared to Standard Biopsies), Quantitative Criteria.
    time Frame
    One day
  3. description
    Eleven preselected pCLE criteria were assessed in their ability to distinguish benign from malignant pleura. Quantitative criteria are presented in this table. Here is presented the mean cellular density
    measure
    Pleural Carcinomatosis Identification (Compared to Standard Biopsies), Quantitative Criteria.
    time Frame
    One day
  4. description
    Eleven preselected pCLE criteria were assessed in their ability to distinguish benign from malignant pleura. Quantitative criteria are presented in this table. Here is presented the vascular density.
    measure
    Pleural Carcinomatosis Identification (Compared to Standard Biopsies), Quantitative Criteria.
    time Frame
    One day
secondary Outcomes
  1. description
    The investigators performing the thoracoscopy had to score the pCLE acquisition. Three level of quality were used: Good, Acceptable, Low.
    measure
    Quality of the pCLE Acquisition
    time Frame
    One day
Full study description
brief Summary
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies"). It was first used in gastroenterology and came later to the light in pulmonary medicine and is still an experimental technique. In gastroenterology, this new investigational technique is used in Barret oesophagus, inflammatory bowel disease, pancreas cystic lesions... Nowadays, there are no data concerning usefulness of endomicroscopy in medical thoracoscopy. During thoracoscopy This new tool could help to target biopsies or help clinicians to do the right diagnosis early, allowing rapid therapeutic intervention (talc pleurodesis for example) . Furthermore, some details can be studied only during live imaging as microorganisms or bloodflows. The investigators performed an endomicroscopy to every patient needing a thoracoscopy (no matter the indication) and who agreed to participate. The pCLE features between malignant and benign pleura were compared in order to find specific criteria for malignant infiltration.
Source references
references
  1. citation
    Bonhomme O, Heinen V, Detrembleur N, Corhay JL, Louis R, Duysinx B. Probe-based confocal laser endomicroscopy for pleural malignancies diagnosis. Respirology. 2021 Feb;26(2):188-195. doi: 10.1111/resp.13945. Epub 2020 Oct 1.
    pmid
    33001538
    type
    DERIVED
Source notices and limitations
    Discovery and provenance
    1. release id
      ctgov-registry-1336d216cbd1bbff780dac70
      edge id
      nct-edge-174f344a5cf59e1128dc
      requested nct id
      NCT03805971
      primary nct id
      NCT03805971
      source kind
      ctgov_condition_query
      source record id
      Source null
      source file sha256
      0a018dbf1aa46f57978b6d16aa19b94d76d6d65cf1e297e889c8e599fef1fab1
      payload sha256
      92ea491b86a88d607ab8fc23bfd987c3228ceca7edfbee4a2d6a1d8f6833c305
      payload
      clinical indication matching status
      condition_index_match_asserted_by_registry_not_reviewed
      end exclusive
      true
      id
      nct-edge-174f344a5cf59e1128dc
      link basis
      returned_by_explicit_condition_and_posted_results_filter_query
      nct id
      NCT03805971
      occurrences
      1. context exact
        NCT03805971
        end
        11
        exact text
        NCT03805971
        start
        0
      offset unit
      unicode_code_points
      query cond
      Malignant Mesothelioma
      query disease state id
      ds-malignant-mesothelioma
      source file
      /Users/arunverma/Documents/ChatGPT/Cancer Statistics Website/research-data/2026-09-10/clinicaltrials-condition/round-0000/raw/cond-malignant-mesothelioma-000.json
      source file sha256
      0a018dbf1aa46f57978b6d16aa19b94d76d6d65cf1e297e889c8e599fef1fab1
      source json pointer
      /studies/77/protocolSection/identificationModule/nctId
      source kind
      ctgov_condition_query
      source record id
      Source null
      source string basis
      parsed_JSON_string_unmodified
      source string sha256
      5c0b4837e16e014b3ed1896a0413cf52c4c7e200d191d06cf97c12ba6f758dd0

    Preserved source evidence · Not medical advice