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NCT03762018 · BASELINE

Baseline characteristics

BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma · Source last updated 2026-07-22

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      200
    2. group Id
      BG001
      value
      200
    3. group Id
      BG002
      value
      400
    units
    Participants
groups
  1. description
    Atezolizumab 1200mg intravenously on day 1 every 3 weeks plus bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks
    id
    BG000
    title
    Atezolizumab Plus Bevacizumab Plus Chemotherapy
  2. description
    Bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks
    id
    BG001
    title
    Bevacizumab Plus Chemotherapy
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          42.3
          upper Limit
          87.6
          value
          70.7
        2. group Id
          BG001
          lower Limit
          47.7
          upper Limit
          88.2
          value
          70.1
        3. group Id
          BG002
          lower Limit
          42.3
          upper Limit
          88.2
          value
          70.4
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          40
        2. group Id
          BG001
          value
          44
        3. group Id
          BG002
          value
          84
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          160
        2. group Id
          BG001
          value
          156
        3. group Id
          BG002
          value
          316
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          199
        2. group Id
          BG001
          value
          200
        3. group Id
          BG002
          value
          399
        title
        White
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        title
        Black
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          11
        3. group Id
          BG002
          value
          26
        title
        Current smoker
      2. measurements
        1. group Id
          BG000
          value
          99
        2. group Id
          BG001
          value
          99
        3. group Id
          BG002
          value
          198
        title
        Former smoker
      3. measurements
        1. group Id
          BG000
          value
          86
        2. group Id
          BG001
          value
          90
        3. group Id
          BG002
          value
          176
        title
        Never smoked
    description
    Current smoker: Still smokes cigarettes, Former smoker: Smoked at least 100 cigarettes in the past during the whole life, Never smoker: Smoked 0-99 cigarettes during the whole life.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Smoking status
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          80
        2. group Id
          BG001
          value
          61
        3. group Id
          BG002
          value
          141
        title
        0
      2. measurements
        1. group Id
          BG000
          value
          119
        2. group Id
          BG001
          value
          139
        3. group Id
          BG002
          value
          258
        title
        1
      3. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        title
        Unknown/Missing
    description
    0: Fully active, able to carry on all pre-disease performance without restriction; 1: Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    ECOG Performance Status
    unit Of Measure
    Participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          43
        2. group Id
          BG001
          value
          41
        3. group Id
          BG002
          value
          84
        title
        IV
      2. measurements
        1. group Id
          BG000
          value
          157
        2. group Id
          BG001
          value
          159
        3. group Id
          BG002
          value
          316
        title
        Other
    description
    Stage is based on the 8th TNM classification for Malignant Pleural Mesothelioma (American Joint Committee on Cancer) and is categorized here as "IV" (advanced stage) vs "Other" including the following stage categories: I (IA or IB), II, III (IIIA or IIIB).
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Stage
    unit Of Measure
    Participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          157
        2. group Id
          BG001
          value
          154
        3. group Id
          BG002
          value
          311
        title
        Epithelioid
      2. measurements
        1. group Id
          BG000
          value
          43
        2. group Id
          BG001
          value
          46
        3. group Id
          BG002
          value
          89
        title
        Non pure epithelioid
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Histology
    unit Of Measure
    Participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          84
        2. group Id
          BG001
          value
          89
        3. group Id
          BG002
          value
          173
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          51
        2. group Id
          BG001
          value
          58
        3. group Id
          BG002
          value
          109
        title
        Possible
      3. measurements
        1. group Id
          BG000
          value
          48
        2. group Id
          BG001
          value
          33
        3. group Id
          BG002
          value
          81
        title
        No
      4. measurements
        1. group Id
          BG000
          value
          17
        2. group Id
          BG001
          value
          20
        3. group Id
          BG002
          value
          37
        title
        Unknown/Missing
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Asbestos exposure
    unit Of Measure
    Participants
  9. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          117
        2. group Id
          BG001
          value
          98
        3. group Id
          BG002
          value
          215
        title
        <1
      2. measurements
        1. group Id
          BG000
          value
          56
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          122
        title
        1-49
      3. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          26
        3. group Id
          BG002
          value
          47
        title
        ≥50
      4. measurements
        1. group Id
          BG000
          value
          6
        2. group Id
          BG001
          value
          10
        3. group Id
          BG002
          value
          16
        title
        Unknown/Missing
    param Type
    COUNT_OF_PARTICIPANTS
    title
    PD-L1 TPS%
    unit Of Measure
    Participants
  10. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          146
        2. group Id
          BG001
          value
          134
        3. group Id
          BG002
          value
          280
        title
        Good prognosis
      2. measurements
        1. group Id
          BG000
          value
          54
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          120
        title
        Poor prognosis
    description
    EORTC PROGNOSTIC SCORE: Curran et al. Journal of Clinical Oncology. 1998 Jan; Vol16:145-152
    param Type
    COUNT_OF_PARTICIPANTS
    title
    EORTC prognostic score
    unit Of Measure
    Participants
  11. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          72
        2. group Id
          BG001
          value
          64
        3. group Id
          BG002
          value
          136
        title
        0-Favorable
      2. measurements
        1. group Id
          BG000
          value
          66
        2. group Id
          BG001
          value
          63
        3. group Id
          BG002
          value
          129
        title
        1-Intermediate
      3. measurements
        1. group Id
          BG000
          value
          62
        2. group Id
          BG001
          value
          73
        3. group Id
          BG002
          value
          135
        title
        2-Poor
    description
    Mesothelioma risk score (MRS): Banna et al. Lung Cancer. 2022 Jul; 169:77-83 The risk factors are baseline systemic immune-inflammatory index (good: \< 1,250 vs poor: ≥ 1,250) and baseline haemoglobin (good: ≥ LLN vs poor: \< LLN) (LLN = 135 for males, LLN = 120 for females))
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Mesothelioma risk score (MRS)
    unit Of Measure
    Participants
  12. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          189
        2. group Id
          BG001
          value
          187
        3. group Id
          BG002
          value
          376
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          11
        2. group Id
          BG001
          value
          13
        3. group Id
          BG002
          value
          24
        title
        No
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Medical history
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      200
    2. group Id
      BG001
      value
      200
    3. group Id
      BG002
      value
      400
    units
    Participants
groups
  1. description
    Atezolizumab 1200mg intravenously on day 1 every 3 weeks plus bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks
    id
    BG000
    title
    Atezolizumab Plus Bevacizumab Plus Chemotherapy
  2. description
    Bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks
    id
    BG001
    title
    Bevacizumab Plus Chemotherapy
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          42.3
          upper Limit
          87.6
          value
          70.7
        2. group Id
          BG001
          lower Limit
          47.7
          upper Limit
          88.2
          value
          70.1
        3. group Id
          BG002
          lower Limit
          42.3
          upper Limit
          88.2
          value
          70.4
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          40
        2. group Id
          BG001
          value
          44
        3. group Id
          BG002
          value
          84
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          160
        2. group Id
          BG001
          value
          156
        3. group Id
          BG002
          value
          316
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          199
        2. group Id
          BG001
          value
          200
        3. group Id
          BG002
          value
          399
        title
        White
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        title
        Black
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          11
        3. group Id
          BG002
          value
          26
        title
        Current smoker
      2. measurements
        1. group Id
          BG000
          value
          99
        2. group Id
          BG001
          value
          99
        3. group Id
          BG002
          value
          198
        title
        Former smoker
      3. measurements
        1. group Id
          BG000
          value
          86
        2. group Id
          BG001
          value
          90
        3. group Id
          BG002
          value
          176
        title
        Never smoked
    description
    Current smoker: Still smokes cigarettes, Former smoker: Smoked at least 100 cigarettes in the past during the whole life, Never smoker: Smoked 0-99 cigarettes during the whole life.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Smoking status
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          80
        2. group Id
          BG001
          value
          61
        3. group Id
          BG002
          value
          141
        title
        0
      2. measurements
        1. group Id
          BG000
          value
          119
        2. group Id
          BG001
          value
          139
        3. group Id
          BG002
          value
          258
        title
        1
      3. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        title
        Unknown/Missing
    description
    0: Fully active, able to carry on all pre-disease performance without restriction; 1: Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    ECOG Performance Status
    unit Of Measure
    Participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          43
        2. group Id
          BG001
          value
          41
        3. group Id
          BG002
          value
          84
        title
        IV
      2. measurements
        1. group Id
          BG000
          value
          157
        2. group Id
          BG001
          value
          159
        3. group Id
          BG002
          value
          316
        title
        Other
    description
    Stage is based on the 8th TNM classification for Malignant Pleural Mesothelioma (American Joint Committee on Cancer) and is categorized here as "IV" (advanced stage) vs "Other" including the following stage categories: I (IA or IB), II, III (IIIA or IIIB).
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Stage
    unit Of Measure
    Participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          157
        2. group Id
          BG001
          value
          154
        3. group Id
          BG002
          value
          311
        title
        Epithelioid
      2. measurements
        1. group Id
          BG000
          value
          43
        2. group Id
          BG001
          value
          46
        3. group Id
          BG002
          value
          89
        title
        Non pure epithelioid
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Histology
    unit Of Measure
    Participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          84
        2. group Id
          BG001
          value
          89
        3. group Id
          BG002
          value
          173
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          51
        2. group Id
          BG001
          value
          58
        3. group Id
          BG002
          value
          109
        title
        Possible
      3. measurements
        1. group Id
          BG000
          value
          48
        2. group Id
          BG001
          value
          33
        3. group Id
          BG002
          value
          81
        title
        No
      4. measurements
        1. group Id
          BG000
          value
          17
        2. group Id
          BG001
          value
          20
        3. group Id
          BG002
          value
          37
        title
        Unknown/Missing
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Asbestos exposure
    unit Of Measure
    Participants
  9. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          117
        2. group Id
          BG001
          value
          98
        3. group Id
          BG002
          value
          215
        title
        <1
      2. measurements
        1. group Id
          BG000
          value
          56
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          122
        title
        1-49
      3. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          26
        3. group Id
          BG002
          value
          47
        title
        ≥50
      4. measurements
        1. group Id
          BG000
          value
          6
        2. group Id
          BG001
          value
          10
        3. group Id
          BG002
          value
          16
        title
        Unknown/Missing
    param Type
    COUNT_OF_PARTICIPANTS
    title
    PD-L1 TPS%
    unit Of Measure
    Participants
  10. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          146
        2. group Id
          BG001
          value
          134
        3. group Id
          BG002
          value
          280
        title
        Good prognosis
      2. measurements
        1. group Id
          BG000
          value
          54
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          120
        title
        Poor prognosis
    description
    EORTC PROGNOSTIC SCORE: Curran et al. Journal of Clinical Oncology. 1998 Jan; Vol16:145-152
    param Type
    COUNT_OF_PARTICIPANTS
    title
    EORTC prognostic score
    unit Of Measure
    Participants
  11. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          72
        2. group Id
          BG001
          value
          64
        3. group Id
          BG002
          value
          136
        title
        0-Favorable
      2. measurements
        1. group Id
          BG000
          value
          66
        2. group Id
          BG001
          value
          63
        3. group Id
          BG002
          value
          129
        title
        1-Intermediate
      3. measurements
        1. group Id
          BG000
          value
          62
        2. group Id
          BG001
          value
          73
        3. group Id
          BG002
          value
          135
        title
        2-Poor
    description
    Mesothelioma risk score (MRS): Banna et al. Lung Cancer. 2022 Jul; 169:77-83 The risk factors are baseline systemic immune-inflammatory index (good: \< 1,250 vs poor: ≥ 1,250) and baseline haemoglobin (good: ≥ LLN vs poor: \< LLN) (LLN = 135 for males, LLN = 120 for females))
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Mesothelioma risk score (MRS)
    unit Of Measure
    Participants
  12. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          189
        2. group Id
          BG001
          value
          187
        3. group Id
          BG002
          value
          376
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          11
        2. group Id
          BG001
          value
          13
        3. group Id
          BG002
          value
          24
        title
        No
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Medical history
    unit Of Measure
    Participants

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