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NCT03755791 · BASELINE

Baseline characteristics

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy · Source last updated 2025-12-11

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      432
    2. group Id
      BG001
      value
      188
    3. group Id
      BG002
      value
      217
    4. group Id
      BG003
      value
      837
    units
    Participants
groups
  1. description
    Participants received 40 mg cabozantinib oral tablets once daily + 1200 mg IV infusion of atezolizumab once every 3 weeks for up to 38 months.
    id
    BG000
    title
    Experimental Arm: Cabozantinib + Atezolizumab
  2. description
    Participants received 60 mg cabozantinib oral tablets once daily for up to 38 months.
    id
    BG001
    title
    Single-Agent Cabozantinib
  3. description
    Participants received 400 mg sorafenib oral tablets twice daily for up to 38 months.
    id
    BG002
    title
    Control Arm: Sorafenib
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        <=18 years
      2. measurements
        1. group Id
          BG000
          value
          234
        2. group Id
          BG001
          value
          97
        3. group Id
          BG002
          value
          112
        4. group Id
          BG003
          value
          443
        title
        Between 18 and 65 years
      3. measurements
        1. group Id
          BG000
          value
          198
        2. group Id
          BG001
          value
          91
        3. group Id
          BG002
          value
          105
        4. group Id
          BG003
          value
          394
        title
        >=65 years
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Categorical
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          72
        2. group Id
          BG001
          value
          30
        3. group Id
          BG002
          value
          31
        4. group Id
          BG003
          value
          133
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          360
        2. group Id
          BG001
          value
          158
        3. group Id
          BG002
          value
          186
        4. group Id
          BG003
          value
          704
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          42
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          15
        4. group Id
          BG003
          value
          78
      title
      Hispanic or Latino
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          352
        2. group Id
          BG001
          value
          158
        3. group Id
          BG002
          value
          183
        4. group Id
          BG003
          value
          693
      title
      Not Hispanic or Latino
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          38
        2. group Id
          BG001
          value
          9
        3. group Id
          BG002
          value
          19
        4. group Id
          BG003
          value
          66
      title
      Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          127
        2. group Id
          BG001
          value
          64
        3. group Id
          BG002
          value
          72
        4. group Id
          BG003
          value
          263
      title
      Asian
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          5
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          14
      title
      Black/African American
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          217
        2. group Id
          BG001
          value
          95
        3. group Id
          BG002
          value
          111
        4. group Id
          BG003
          value
          423
      title
      White
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          80
        2. group Id
          BG001
          value
          24
        3. group Id
          BG002
          value
          33
        4. group Id
          BG003
          value
          137
      title
      Other than specified
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
population Description
The Intent-to-Treat (ITT) population consisted of all participants who were randomized to any of the three study treatment arms, regardless of whether they received any study treatment.
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      432
    2. group Id
      BG001
      value
      188
    3. group Id
      BG002
      value
      217
    4. group Id
      BG003
      value
      837
    units
    Participants
groups
  1. description
    Participants received 40 mg cabozantinib oral tablets once daily + 1200 mg IV infusion of atezolizumab once every 3 weeks for up to 38 months.
    id
    BG000
    title
    Experimental Arm: Cabozantinib + Atezolizumab
  2. description
    Participants received 60 mg cabozantinib oral tablets once daily for up to 38 months.
    id
    BG001
    title
    Single-Agent Cabozantinib
  3. description
    Participants received 400 mg sorafenib oral tablets twice daily for up to 38 months.
    id
    BG002
    title
    Control Arm: Sorafenib
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        <=18 years
      2. measurements
        1. group Id
          BG000
          value
          234
        2. group Id
          BG001
          value
          97
        3. group Id
          BG002
          value
          112
        4. group Id
          BG003
          value
          443
        title
        Between 18 and 65 years
      3. measurements
        1. group Id
          BG000
          value
          198
        2. group Id
          BG001
          value
          91
        3. group Id
          BG002
          value
          105
        4. group Id
          BG003
          value
          394
        title
        >=65 years
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Categorical
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          72
        2. group Id
          BG001
          value
          30
        3. group Id
          BG002
          value
          31
        4. group Id
          BG003
          value
          133
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          360
        2. group Id
          BG001
          value
          158
        3. group Id
          BG002
          value
          186
        4. group Id
          BG003
          value
          704
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          42
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          15
        4. group Id
          BG003
          value
          78
      title
      Hispanic or Latino
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          352
        2. group Id
          BG001
          value
          158
        3. group Id
          BG002
          value
          183
        4. group Id
          BG003
          value
          693
      title
      Not Hispanic or Latino
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          38
        2. group Id
          BG001
          value
          9
        3. group Id
          BG002
          value
          19
        4. group Id
          BG003
          value
          66
      title
      Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          127
        2. group Id
          BG001
          value
          64
        3. group Id
          BG002
          value
          72
        4. group Id
          BG003
          value
          263
      title
      Asian
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          5
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          14
      title
      Black/African American
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          217
        2. group Id
          BG001
          value
          95
        3. group Id
          BG002
          value
          111
        4. group Id
          BG003
          value
          423
      title
      White
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          80
        2. group Id
          BG001
          value
          24
        3. group Id
          BG002
          value
          33
        4. group Id
          BG003
          value
          137
      title
      Other than specified
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
population Description
The Intent-to-Treat (ITT) population consisted of all participants who were randomized to any of the three study treatment arms, regardless of whether they received any study treatment.

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Preserved source evidence · Not medical advice