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NCT03674411 · OUTCOME

Percentage of Participants With Neutrophil Recover

Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy · Source last updated 2026-01-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
Percentage of participants
Interval / dispersion
95% Confidence Interval
Time frame
Day 14

What was measured

Percentage of participants with neutrophil recovery by day 14 after transplantation in recipients of MGTA-456.

Groups in this outcome

FLU, CY, TBI + MGTA-456 Infusion

All patients aged 3-55 years will be conditioned with cyclophosphamide (CY) 120 mg/kg total dose, fludarabine (FLU) 75 m/m2 total dose and total body irradiation (TBI) 1320 cGy total dose as well as tacrolimus (Tac) and mycophenolate mofetil (MMF) immunoprophylaxis and granulocyte-colony stimulating factor (G-CSF)

BU,FLU, MEL + MGTA-456 Infusion

All young children \<3 years of age at the time of diagnosis will receive MGTA-456 on the day of transplantation after a non-TBI containing myeloablative conditioning as TBI may have a damaging effect on brain development in the very young child. All patients aged 0-3 years will be conditioned with busulfan (BU), FLU and melphalan (MEL) as well as Tac/MMF immunoprophylaxis and G-CSF

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
FLU, CY, TBI + MGTA-456 Infusion16
BU,FLU, MEL + MGTA-456 Infusion2

Reported measurements

Source class 1
Values in Percentage of participants · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
FLU, CY, TBI + MGTA-456 Infusion31Not reported1460Not reported
BU,FLU, MEL + MGTA-456 Infusion50Not reported999Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        14
        upper Limit
        60
        value
        31
      2. group Id
        OG001
        lower Limit
        9
        upper Limit
        99
        value
        50
denoms
  1. counts
    1. group Id
      OG000
      value
      16
    2. group Id
      OG001
      value
      2
    units
    Participants
description
Percentage of participants with neutrophil recovery by day 14 after transplantation in recipients of MGTA-456.
dispersion Type
95% Confidence Interval
groups
  1. description
    All patients aged 3-55 years will be conditioned with cyclophosphamide (CY) 120 mg/kg total dose, fludarabine (FLU) 75 m/m2 total dose and total body irradiation (TBI) 1320 cGy total dose as well as tacrolimus (Tac) and mycophenolate mofetil (MMF) immunoprophylaxis and granulocyte-colony stimulating factor (G-CSF)
    id
    OG000
    title
    FLU, CY, TBI + MGTA-456 Infusion
  2. description
    All young children \<3 years of age at the time of diagnosis will receive MGTA-456 on the day of transplantation after a non-TBI containing myeloablative conditioning as TBI may have a damaging effect on brain development in the very young child. All patients aged 0-3 years will be conditioned with busulfan (BU), FLU and melphalan (MEL) as well as Tac/MMF immunoprophylaxis and G-CSF
    id
    OG001
    title
    BU,FLU, MEL + MGTA-456 Infusion
param Type
NUMBER
reporting Status
POSTED
time Frame
Day 14
title
Percentage of Participants With Neutrophil Recover
type
PRIMARY
unit Of Measure
Percentage of participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice