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NCT03673501 · BASELINE

Baseline characteristics

A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib · Source last updated 2026-02-05

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      226
    2. group Id
      BG001
      value
      227
    3. group Id
      BG002
      value
      453
    units
    Participants
groups
  1. description
    Ripretinib (150 mg) once a day continuous dosing for 6-week (42 days) cycles
    id
    BG000
    title
    Ripretinib
  2. description
    Sunitinib (50 mg) once a day in 6-week (42 days) cycles with 4 weeks continuous dosing followed by 2 week break.
    id
    BG001
    title
    Sunitinib
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          145
        2. group Id
          BG001
          value
          143
        3. group Id
          BG002
          value
          288
        title
        18-64 years
      2. measurements
        1. group Id
          BG000
          value
          56
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          122
        title
        65-74 years
      3. measurements
        1. group Id
          BG000
          value
          25
        2. group Id
          BG001
          value
          18
        3. group Id
          BG002
          value
          43
        title
        75 years and older
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Customized
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          87
        2. group Id
          BG001
          value
          85
        3. group Id
          BG002
          value
          172
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          139
        2. group Id
          BG001
          value
          142
        3. group Id
          BG002
          value
          281
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          28
        title
        Black or African American
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          1
        title
        American Indian or Alaska Native
      3. measurements
        1. group Id
          BG000
          value
          31
        2. group Id
          BG001
          value
          27
        3. group Id
          BG002
          value
          58
        title
        Asian
      4. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          3
        title
        Native Hawaiian or Other Pacific Islander
      5. measurements
        1. group Id
          BG000
          value
          148
        2. group Id
          BG001
          value
          152
        3. group Id
          BG002
          value
          300
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          30
        2. group Id
          BG001
          value
          30
        3. group Id
          BG002
          value
          60
        title
        Not Report
      7. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          3
        title
        Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          131
        2. group Id
          BG001
          value
          128
        3. group Id
          BG002
          value
          259
        title
        ECOG Score 0
      2. measurements
        1. group Id
          BG000
          value
          92
        2. group Id
          BG001
          value
          98
        3. group Id
          BG002
          value
          190
        title
        ECOG Score 1
      3. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          4
        title
        ECOG Score 2
    description
    An ECOG Score of 0 means the participant is fully active, able to carry on all pre-disease performance without restriction ECOG Score of 1 means the participant is restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g. light house work, office work ECOG Score of 2 means the participant is ambulatory and capable of all self-care but unable to carry out any work activities; up and about more than 50% of waking hours
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Eastern Cooperative Oncology Group (ECOG) Score at Screening
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          31
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          59
        title
        KIT Exon 9
      2. measurements
        1. group Id
          BG000
          value
          167
        2. group Id
          BG001
          value
          169
        3. group Id
          BG002
          value
          336
        title
        KIT Exon 11
      3. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          16
        3. group Id
          BG002
          value
          30
        title
        KIT/PDGFRA WT
      4. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          28
        title
        Other KIT (absence of Exon 9 or 11)/PDGFRA
    description
    Electronic Data Capture (EDC) is a system used to capture patient information in a clinical trial. The data is presented based on how many participants had the KIT proto-oncogene receptor tyrosine kinase (KIT) Exon 9 mutation, KIT Exon 11 mutation, the KIT/platelet-derived growth factor receptor alpha (PDGFRA) wild type (WT) mutation, or other KIT (absence of Exon 9 or 11)/PDGFRA mutations.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Mutation Type per Electronic Data Capture (EDC)
    unit Of Measure
    Participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          19
        3. group Id
          BG002
          value
          34
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          211
        2. group Id
          BG001
          value
          208
        3. group Id
          BG002
          value
          419
        title
        No
    description
    Electronic Data Capture (EDC) is a system used to capture patient information in a clinical trial. The data is presented based on participants that were intolerant to imatinib or not.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Intolerance to Imatinib per Electronic Data Capture (EDC)
    unit Of Measure
    Participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          31
        2. group Id
          BG001
          value
          29
        3. group Id
          BG002
          value
          60
        title
        KIT Exon 9
      2. measurements
        1. group Id
          BG000
          value
          163
        2. group Id
          BG001
          value
          164
        3. group Id
          BG002
          value
          327
        title
        KIT Exon 11
      3. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          18
        3. group Id
          BG002
          value
          33
        title
        KIT/PDGFRA wild type (WT)
      4. measurements
        1. group Id
          BG000
          value
          17
        2. group Id
          BG001
          value
          16
        3. group Id
          BG002
          value
          33
        title
        Other KIT (absence of Exon 9 or 11)/PDGFRA
    description
    Interactive Response Technology (IRT) is a randomization and trial supply system that randomly assigns patients to one of the study treatments and supplies study drug. The data is presented based on the participant's Mutational Status: KIT exon 9 mutation; KIT exon 11 mutation; KIT/PDGFRA wild type (WT); or other KIT (absence of exon 9 or 11)/PDGFRA mutations
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Mutation Type per Interactive Response Technology (IRT)
    unit Of Measure
    Participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          22
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          45
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          204
        2. group Id
          BG001
          value
          204
        3. group Id
          BG002
          value
          408
        title
        No
    description
    Interactive Response Technology (IRT) is a randomization and trial supply system that randomly assigns patients to one of the study treatments and supplies study drug. The data is presented based on whether the participants were intolerant to imatinib or not.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Intolerance to Imatinib per Interactive Response Technology (IRT)
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      226
    2. group Id
      BG001
      value
      227
    3. group Id
      BG002
      value
      453
    units
    Participants
groups
  1. description
    Ripretinib (150 mg) once a day continuous dosing for 6-week (42 days) cycles
    id
    BG000
    title
    Ripretinib
  2. description
    Sunitinib (50 mg) once a day in 6-week (42 days) cycles with 4 weeks continuous dosing followed by 2 week break.
    id
    BG001
    title
    Sunitinib
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          145
        2. group Id
          BG001
          value
          143
        3. group Id
          BG002
          value
          288
        title
        18-64 years
      2. measurements
        1. group Id
          BG000
          value
          56
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          122
        title
        65-74 years
      3. measurements
        1. group Id
          BG000
          value
          25
        2. group Id
          BG001
          value
          18
        3. group Id
          BG002
          value
          43
        title
        75 years and older
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Customized
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          87
        2. group Id
          BG001
          value
          85
        3. group Id
          BG002
          value
          172
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          139
        2. group Id
          BG001
          value
          142
        3. group Id
          BG002
          value
          281
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          28
        title
        Black or African American
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          1
        title
        American Indian or Alaska Native
      3. measurements
        1. group Id
          BG000
          value
          31
        2. group Id
          BG001
          value
          27
        3. group Id
          BG002
          value
          58
        title
        Asian
      4. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          3
        title
        Native Hawaiian or Other Pacific Islander
      5. measurements
        1. group Id
          BG000
          value
          148
        2. group Id
          BG001
          value
          152
        3. group Id
          BG002
          value
          300
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          30
        2. group Id
          BG001
          value
          30
        3. group Id
          BG002
          value
          60
        title
        Not Report
      7. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          3
        title
        Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          131
        2. group Id
          BG001
          value
          128
        3. group Id
          BG002
          value
          259
        title
        ECOG Score 0
      2. measurements
        1. group Id
          BG000
          value
          92
        2. group Id
          BG001
          value
          98
        3. group Id
          BG002
          value
          190
        title
        ECOG Score 1
      3. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          4
        title
        ECOG Score 2
    description
    An ECOG Score of 0 means the participant is fully active, able to carry on all pre-disease performance without restriction ECOG Score of 1 means the participant is restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g. light house work, office work ECOG Score of 2 means the participant is ambulatory and capable of all self-care but unable to carry out any work activities; up and about more than 50% of waking hours
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Eastern Cooperative Oncology Group (ECOG) Score at Screening
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          31
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          59
        title
        KIT Exon 9
      2. measurements
        1. group Id
          BG000
          value
          167
        2. group Id
          BG001
          value
          169
        3. group Id
          BG002
          value
          336
        title
        KIT Exon 11
      3. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          16
        3. group Id
          BG002
          value
          30
        title
        KIT/PDGFRA WT
      4. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          28
        title
        Other KIT (absence of Exon 9 or 11)/PDGFRA
    description
    Electronic Data Capture (EDC) is a system used to capture patient information in a clinical trial. The data is presented based on how many participants had the KIT proto-oncogene receptor tyrosine kinase (KIT) Exon 9 mutation, KIT Exon 11 mutation, the KIT/platelet-derived growth factor receptor alpha (PDGFRA) wild type (WT) mutation, or other KIT (absence of Exon 9 or 11)/PDGFRA mutations.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Mutation Type per Electronic Data Capture (EDC)
    unit Of Measure
    Participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          19
        3. group Id
          BG002
          value
          34
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          211
        2. group Id
          BG001
          value
          208
        3. group Id
          BG002
          value
          419
        title
        No
    description
    Electronic Data Capture (EDC) is a system used to capture patient information in a clinical trial. The data is presented based on participants that were intolerant to imatinib or not.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Intolerance to Imatinib per Electronic Data Capture (EDC)
    unit Of Measure
    Participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          31
        2. group Id
          BG001
          value
          29
        3. group Id
          BG002
          value
          60
        title
        KIT Exon 9
      2. measurements
        1. group Id
          BG000
          value
          163
        2. group Id
          BG001
          value
          164
        3. group Id
          BG002
          value
          327
        title
        KIT Exon 11
      3. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          18
        3. group Id
          BG002
          value
          33
        title
        KIT/PDGFRA wild type (WT)
      4. measurements
        1. group Id
          BG000
          value
          17
        2. group Id
          BG001
          value
          16
        3. group Id
          BG002
          value
          33
        title
        Other KIT (absence of Exon 9 or 11)/PDGFRA
    description
    Interactive Response Technology (IRT) is a randomization and trial supply system that randomly assigns patients to one of the study treatments and supplies study drug. The data is presented based on the participant's Mutational Status: KIT exon 9 mutation; KIT exon 11 mutation; KIT/PDGFRA wild type (WT); or other KIT (absence of exon 9 or 11)/PDGFRA mutations
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Mutation Type per Interactive Response Technology (IRT)
    unit Of Measure
    Participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          22
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          45
        title
        Yes
      2. measurements
        1. group Id
          BG000
          value
          204
        2. group Id
          BG001
          value
          204
        3. group Id
          BG002
          value
          408
        title
        No
    description
    Interactive Response Technology (IRT) is a randomization and trial supply system that randomly assigns patients to one of the study treatments and supplies study drug. The data is presented based on whether the participants were intolerant to imatinib or not.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Intolerance to Imatinib per Interactive Response Technology (IRT)
    unit Of Measure
    Participants

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Preserved source evidence · Not medical advice