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NCT03589469 · OUTCOME

Duration of Response (DOR)

Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma · Source last updated 2023-08-29

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
months
Interval / dispersion
95% Confidence Interval
Time frame
Up to 39 months

What was measured

DOR defined as the time from the first documentation of tumor response to disease progression or death.

Analysis population: Participants in the all-treated population who achieved a complete response (CR) or partial response (PR).

Groups in this outcome

Loncastuximab Tesirine

Participants received loncastuximab tesirine as an IV infusion over 30 minutes on Day 1 of each cycle (every 3 weeks) at a dose of 150 μg/kg Q3W for 2 cycles, then 75 μg/kg Q3W for subsequent cycles for up to one year or until disease progression, unacceptable toxicity, or other discontinuation criteria, whichever occurred first.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Loncastuximab Tesirine70

Reported measurements

Source class 1
Values in months · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Loncastuximab Tesirine13.37Not reported6.87NAUpper confidence interval could not be calculated due to insufficient number of participants with events.
Complete source fields
classes
  1. categories
    1. measurements
      1. comment
        Upper confidence interval could not be calculated due to insufficient number of participants with events.
        group Id
        OG000
        lower Limit
        6.87
        upper Limit
        NA
        value
        13.37
denoms
  1. counts
    1. group Id
      OG000
      value
      70
    units
    Participants
description
DOR defined as the time from the first documentation of tumor response to disease progression or death.
dispersion Type
95% Confidence Interval
groups
  1. description
    Participants received loncastuximab tesirine as an IV infusion over 30 minutes on Day 1 of each cycle (every 3 weeks) at a dose of 150 μg/kg Q3W for 2 cycles, then 75 μg/kg Q3W for subsequent cycles for up to one year or until disease progression, unacceptable toxicity, or other discontinuation criteria, whichever occurred first.
    id
    OG000
    title
    Loncastuximab Tesirine
param Type
MEDIAN
population Description
Participants in the all-treated population who achieved a complete response (CR) or partial response (PR).
reporting Status
POSTED
time Frame
Up to 39 months
title
Duration of Response (DOR)
type
SECONDARY
unit Of Measure
months

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice