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NCT03580655 · OUTCOME

Correlation Between TSS and Serum Tryptase

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis · Source last updated 2026-04-24

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
Spearman Coefficient
Interval / dispersion
Not reported
Time frame
Baseline, Month 10

What was measured

The change in baseline for AdvSM-SAF TSS was correlated with the change in baseline for serum tryptase. Spearman correlation coefficients were performed with corresponding scatter plots on change from baseline.

Analysis population: Safety Population: all participants who received ≥1 dose of avapritinib.

Groups in this outcome

Avapritinib

Avapritinib was administered once daily as an immediate-release tablet, orally, in 28-day cycles.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Avapritinib107

Reported measurements

Source class 1
Values in Spearman Coefficient · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Avapritinib0.1043Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        0.1043
denoms
  1. counts
    1. group Id
      OG000
      value
      107
    units
    Participants
description
The change in baseline for AdvSM-SAF TSS was correlated with the change in baseline for serum tryptase. Spearman correlation coefficients were performed with corresponding scatter plots on change from baseline.
groups
  1. description
    Avapritinib was administered once daily as an immediate-release tablet, orally, in 28-day cycles.
    id
    OG000
    title
    Avapritinib
param Type
NUMBER
population Description
Safety Population: all participants who received ≥1 dose of avapritinib.
reporting Status
POSTED
time Frame
Baseline, Month 10
title
Correlation Between TSS and Serum Tryptase
type
SECONDARY
unit Of Measure
Spearman Coefficient

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice