Baseline characteristics

DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03] · Source last updated 2025-10-21

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms

1. counts

   1. group Id

      BG000

      value

      261

   2. group Id

      BG001

      value

      263

   3. group Id

      BG002

      value

      524

   units

   Participants

groups

1. description

   Participants with HER2-positive, unresectable and/or metastatic breast cancer participants previously treated with trastuzumab and taxane who received T-DXd as a sterile intravenous (IV) solution at a dose of 5.4 mg/kg every 3 weeks (Q3W).

   id

   BG000

   title

   Trastuzumab Deruxtecan (T-DXd)

2. description

   Participants with HER2-positive, unresectable and/or metastatic breast cancer participants previously treated with trastuzumab and taxane who received T-DM1 in accordance with the approved label.

   id

   BG001

   title

   Ado-trastuzumab Emtansine (T-DM1)

3. description

   Total of all reporting groups

   id

   BG002

   title

   Total

measures

1. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         title

         <=18 years

      2. measurements

         1. group Id

            BG000

            value

            212

         2. group Id

            BG001

            value

            206

         3. group Id

            BG002

            value

            418

         title

         Between 18 and 65 years

      3. measurements

         1. group Id

            BG000

            value

            49

         2. group Id

            BG001

            value

            57

         3. group Id

            BG002

            value

            106

         title

         >=65 years

   param Type

   COUNT_OF_PARTICIPANTS

   title

   Age, Categorical

   unit Of Measure

   Participants

2. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            spread

            11.11

            value

            54.5

         2. group Id

            BG001

            spread

            11.84

            value

            54.2

         3. group Id

            BG002

            spread

            11.47

            value

            54.4

   dispersion Type

   STANDARD_DEVIATION

   param Type

   MEDIAN

   title

   Age, Continuous

   unit Of Measure

   years

3. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            value

            260

         2. group Id

            BG001

            value

            262

         3. group Id

            BG002

            value

            522

         title

         Female

      2. measurements

         1. group Id

            BG000

            value

            1

         2. group Id

            BG001

            value

            1

         3. group Id

            BG002

            value

            2

         title

         Male

   param Type

   COUNT_OF_PARTICIPANTS

   title

   Sex: Female, Male

   unit Of Measure

   Participants

4. classes

   1. categories

      1. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         title

         American Indian or Alaska Native

      2. measurements

         1. group Id

            BG000

            value

            152

         2. group Id

            BG001

            value

            162

         3. group Id

            BG002

            value

            314

         title

         Asian

      3. measurements

         1. group Id

            BG000

            value

            0

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            0

         title

         Native Hawaiian or Other Pacific Islander

      4. measurements

         1. group Id

            BG000

            value

            10

         2. group Id

            BG001

            value

            9

         3. group Id

            BG002

            value

            19

         title

         Black or African American

      5. measurements

         1. group Id

            BG000

            value

            71

         2. group Id

            BG001

            value

            72

         3. group Id

            BG002

            value

            143

         title

         White

      6. measurements

         1. group Id

            BG000

            value

            2

         2. group Id

            BG001

            value

            0

         3. group Id

            BG002

            value

            2

         title

         More than one race

      7. measurements

         1. group Id

            BG000

            value

            26

         2. group Id

            BG001

            value

            20

         3. group Id

            BG002

            value

            46

         title

         Unknown or Not Reported

   param Type

   COUNT_OF_PARTICIPANTS

   title

   Race (NIH/OMB)

   unit Of Measure

   Participants

population Description

Baseline characteristics were assessed using the Full Analysis Set.

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Preserved source evidence · Not medical advice