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NCT03523585 · BASELINE

Baseline characteristics

DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or Has Spread [DESTINY-Breast02] · Source last updated 2026-02-27

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      406
    2. group Id
      BG001
      value
      91
    3. group Id
      BG002
      value
      111
    4. group Id
      BG003
      value
      608
    units
    Participants
groups
  1. description
    Participants with HER2 positive, unresectable and/or metastatic breast cancer participants previously treated with standard of care HER2 therapies, including ado-trastuzumab emtansine (T-DM1), who received T-DXd as a sterile intravenous (IV) solution at a dose of 5.4 mg/kg every 3 weeks (Q3W).
    id
    BG000
    title
    Trastuzumab Deruxtecan (T-DXd)
  2. description
    Participants with HER2 positive, unresectable and/or metastatic breast cancer participants previously treated with standard of care HER2 therapies, including ado-trastuzumab emtansine (T-DM1), who received investigator's choice treatment, Trastuzumab/Capecitabine.
    id
    BG001
    title
    Trastuzumab+Capecitabine
  3. description
    Participants with HER2 positive, unresectable and/or metastatic breast cancer participants previously treated with standard of care HER2 therapies, including ado-trastuzumab emtansine (T-DM1), who received investigator's choice treatment, Lapatinib/Capecitabine.
    id
    BG002
    title
    Lapatinib+Capecitabine
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        <=18 years
      2. measurements
        1. group Id
          BG000
          value
          321
        2. group Id
          BG001
          value
          73
        3. group Id
          BG002
          value
          91
        4. group Id
          BG003
          value
          485
        title
        Between 18 and 65 years
      3. measurements
        1. group Id
          BG000
          value
          85
        2. group Id
          BG001
          value
          18
        3. group Id
          BG002
          value
          20
        4. group Id
          BG003
          value
          123
        title
        >=65 years
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Categorical
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          11.99
          value
          54.6
        2. group Id
          BG001
          spread
          11.40
          value
          55.7
        3. group Id
          BG002
          spread
          11.06
          value
          54.6
        4. group Id
          BG003
          spread
          11.73
          value
          54.8
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          403
        2. group Id
          BG001
          value
          89
        3. group Id
          BG002
          value
          111
        4. group Id
          BG003
          value
          603
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          5
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          2
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          122
        2. group Id
          BG001
          value
          20
        3. group Id
          BG002
          value
          36
        4. group Id
          BG003
          value
          178
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          10
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          5
        4. group Id
          BG003
          value
          17
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          257
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          61
        4. group Id
          BG003
          value
          384
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          26
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          41
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          9
        4. group Id
          BG003
          value
          64
      title
      United States
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          3
      title
      Czechia
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          46
        2. group Id
          BG001
          value
          6
        3. group Id
          BG002
          value
          18
        4. group Id
          BG003
          value
          70
      title
      Japan
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          27
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          4
        4. group Id
          BG003
          value
          35
      title
      United Kingdom
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          29
        2. group Id
          BG001
          value
          8
        3. group Id
          BG002
          value
          7
        4. group Id
          BG003
          value
          44
      title
      Spain
    6. categories
      1. measurements
        1. group Id
          BG000
          value
          9
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          14
      title
      Greece
    7. categories
      1. measurements
        1. group Id
          BG000
          value
          66
        2. group Id
          BG001
          value
          11
        3. group Id
          BG002
          value
          17
        4. group Id
          BG003
          value
          94
      title
      South Korea
    8. categories
      1. measurements
        1. group Id
          BG000
          value
          36
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          4
        4. group Id
          BG003
          value
          52
      title
      Turkey
    9. categories
      1. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          5
      title
      Belgium
    10. categories
      1. measurements
        1. group Id
          BG000
          value
          41
        2. group Id
          BG001
          value
          10
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          59
      title
      Brazil
    11. categories
      1. measurements
        1. group Id
          BG000
          value
          33
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          17
        4. group Id
          BG003
          value
          53
      title
      Italy
    12. categories
      1. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          4
        4. group Id
          BG003
          value
          18
      title
      Israel
    param Type
    NUMBER
    title
    Region of Enrollment
    unit Of Measure
    participants
population Description
Baseline characteristics were assessed using the Full Analysis Set.
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      406
    2. group Id
      BG001
      value
      91
    3. group Id
      BG002
      value
      111
    4. group Id
      BG003
      value
      608
    units
    Participants
groups
  1. description
    Participants with HER2 positive, unresectable and/or metastatic breast cancer participants previously treated with standard of care HER2 therapies, including ado-trastuzumab emtansine (T-DM1), who received T-DXd as a sterile intravenous (IV) solution at a dose of 5.4 mg/kg every 3 weeks (Q3W).
    id
    BG000
    title
    Trastuzumab Deruxtecan (T-DXd)
  2. description
    Participants with HER2 positive, unresectable and/or metastatic breast cancer participants previously treated with standard of care HER2 therapies, including ado-trastuzumab emtansine (T-DM1), who received investigator's choice treatment, Trastuzumab/Capecitabine.
    id
    BG001
    title
    Trastuzumab+Capecitabine
  3. description
    Participants with HER2 positive, unresectable and/or metastatic breast cancer participants previously treated with standard of care HER2 therapies, including ado-trastuzumab emtansine (T-DM1), who received investigator's choice treatment, Lapatinib/Capecitabine.
    id
    BG002
    title
    Lapatinib+Capecitabine
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        <=18 years
      2. measurements
        1. group Id
          BG000
          value
          321
        2. group Id
          BG001
          value
          73
        3. group Id
          BG002
          value
          91
        4. group Id
          BG003
          value
          485
        title
        Between 18 and 65 years
      3. measurements
        1. group Id
          BG000
          value
          85
        2. group Id
          BG001
          value
          18
        3. group Id
          BG002
          value
          20
        4. group Id
          BG003
          value
          123
        title
        >=65 years
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Categorical
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          11.99
          value
          54.6
        2. group Id
          BG001
          spread
          11.40
          value
          55.7
        3. group Id
          BG002
          spread
          11.06
          value
          54.6
        4. group Id
          BG003
          spread
          11.73
          value
          54.8
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          403
        2. group Id
          BG001
          value
          89
        3. group Id
          BG002
          value
          111
        4. group Id
          BG003
          value
          603
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          5
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          2
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          122
        2. group Id
          BG001
          value
          20
        3. group Id
          BG002
          value
          36
        4. group Id
          BG003
          value
          178
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          10
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          5
        4. group Id
          BG003
          value
          17
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          257
        2. group Id
          BG001
          value
          66
        3. group Id
          BG002
          value
          61
        4. group Id
          BG003
          value
          384
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          26
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          41
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          9
        4. group Id
          BG003
          value
          64
      title
      United States
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          3
      title
      Czechia
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          46
        2. group Id
          BG001
          value
          6
        3. group Id
          BG002
          value
          18
        4. group Id
          BG003
          value
          70
      title
      Japan
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          27
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          4
        4. group Id
          BG003
          value
          35
      title
      United Kingdom
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          29
        2. group Id
          BG001
          value
          8
        3. group Id
          BG002
          value
          7
        4. group Id
          BG003
          value
          44
      title
      Spain
    6. categories
      1. measurements
        1. group Id
          BG000
          value
          9
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          14
      title
      Greece
    7. categories
      1. measurements
        1. group Id
          BG000
          value
          66
        2. group Id
          BG001
          value
          11
        3. group Id
          BG002
          value
          17
        4. group Id
          BG003
          value
          94
      title
      South Korea
    8. categories
      1. measurements
        1. group Id
          BG000
          value
          36
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          4
        4. group Id
          BG003
          value
          52
      title
      Turkey
    9. categories
      1. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          5
      title
      Belgium
    10. categories
      1. measurements
        1. group Id
          BG000
          value
          41
        2. group Id
          BG001
          value
          10
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          59
      title
      Brazil
    11. categories
      1. measurements
        1. group Id
          BG000
          value
          33
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          17
        4. group Id
          BG003
          value
          53
      title
      Italy
    12. categories
      1. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          4
        4. group Id
          BG003
          value
          18
      title
      Israel
    param Type
    NUMBER
    title
    Region of Enrollment
    unit Of Measure
    participants
population Description
Baseline characteristics were assessed using the Full Analysis Set.

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice