NCT03484702 · OUTCOME
Number of Participants With Increase From Baseline in Select Serum Chemistry Parameters - Cohorts 1, 2, 3, 4, and 5
Trial to Determine the Efficacy and Safety of JCAR017 in Adult Participants With Aggressive B-Cell Non-Hodgkin Lymphoma · Source last updated 2024-12-27
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- COUNT_OF_PARTICIPANTS
- Unit
- Participants
- Interval / dispersion
- Not reported
- Time frame
- At Baseline and Day 29 after JCAR017 infusion
What was measured
JCAR017 treatment-emergent laboratory abnormalities are defined as an abnormality that, compared to baseline, worsens by at least one grade after JCAR017 infusion. The baseline value is defined as the last available recorded value on or prior to the date of JCAR017 infusion. Grade 1 = Mild, Grade 2 =Moderate, Grade 3 =Severe, Grade 4 =Life-threatening, Grade 5 =Death.
Analysis population: All participants in the JCAR017 treated set with available baseline and Day 29 serum chemistry results. Prespecified to be reported for cohorts 1, 2, 3, 4, and 5 only.
Groups in this outcome
Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy
JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy
JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2
JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma
JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
Cohort 5: Primary Central Nervous System Lymphoma
JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Reported measurements
Albumin (g/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
Phosphate (mmol/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
Alkaline Phosphatase (U/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 2 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
Alanine Aminotransferase (U/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 10 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 3 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 2 | Not reported | Not reported | Not reported | Not reported |
|---|
Aspartate Aminotransferase (U/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 23 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 6 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 3 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 3 | Not reported | Not reported | Not reported | Not reported |
|---|
Bilirubin (umol/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 34 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 23 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 2 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
Creatinine (umol/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 23 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 20 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 6 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 3 | Not reported | Not reported | Not reported | Not reported |
|---|
Triglycerides (mmol/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 10 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 6 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 2 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 2 | Not reported | Not reported | Not reported | Not reported |
|---|
Urate (umol/L) - Day 29
Analysis denominator · Participants
| Group | Source count |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 35 |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 24 |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 10 |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 1 |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 4 |
|---|
Values in Participants · Interval/dispersion: Not reported| Group | Value | Spread | Lower | Upper | Comment |
|---|
| Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy | 1 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2 | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
| Cohort 5: Primary Central Nervous System Lymphoma | 0 | Not reported | Not reported | Not reported | Not reported |
|---|
Complete source fields
- classes
- categories
- measurements
- group Id
- OG000
- value
- 0
- group Id
- OG001
- value
- 0
- group Id
- OG002
- value
- 0
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 0
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Albumin (g/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 0
- group Id
- OG001
- value
- 1
- group Id
- OG002
- value
- 0
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 0
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Phosphate (mmol/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 2
- group Id
- OG001
- value
- 1
- group Id
- OG002
- value
- 0
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 1
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Alkaline Phosphatase (U/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 10
- group Id
- OG001
- value
- 3
- group Id
- OG002
- value
- 1
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 2
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Alanine Aminotransferase (U/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 6
- group Id
- OG001
- value
- 3
- group Id
- OG002
- value
- 1
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 3
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 23
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Aspartate Aminotransferase (U/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 2
- group Id
- OG001
- value
- 0
- group Id
- OG002
- value
- 0
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 0
- denoms
- counts
- group Id
- OG000
- value
- 34
- group Id
- OG001
- value
- 23
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Bilirubin (umol/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 23
- group Id
- OG001
- value
- 20
- group Id
- OG002
- value
- 6
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 3
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Creatinine (umol/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 10
- group Id
- OG001
- value
- 6
- group Id
- OG002
- value
- 2
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 2
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Triglycerides (mmol/L) - Day 29
- categories
- measurements
- group Id
- OG000
- value
- 1
- group Id
- OG001
- value
- 0
- group Id
- OG002
- value
- 0
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 0
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- title
- Urate (umol/L) - Day 29
- denoms
- counts
- group Id
- OG000
- value
- 35
- group Id
- OG001
- value
- 24
- group Id
- OG002
- value
- 10
- group Id
- OG003
- value
- 1
- group Id
- OG004
- value
- 4
- units
- Participants
- description
- JCAR017 treatment-emergent laboratory abnormalities are defined as an abnormality that, compared to baseline, worsens by at least one grade after JCAR017 infusion. The baseline value is defined as the last available recorded value on or prior to the date of JCAR017 infusion. Grade 1 = Mild, Grade 2 =Moderate, Grade 3 =Severe, Grade 4 =Life-threatening, Grade 5 =Death.
- groups
- description
- JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
- id
- OG000
- title
- Cohort 1: Diffuse B-cell Lymphoma Who Failed ≥ 2 Lines of Therapy
- description
- JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
- id
- OG001
- title
- Cohort 2: Transplant Ineligible Diffuse B-cell Lymphoma Who Failed First Line Therapy
- description
- JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
- id
- OG002
- title
- Cohort 3: Japan Specific - Meeting Eligibility Criteria for Cohort 1 or 2
- description
- JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
- id
- OG003
- title
- Cohort 4: Newly Diagnosed High-Grade B-cell Lymphoma
- description
- JCAR017 was infused at a dose of 100 x 10\^6 JCAR017-positive transfected viable T cells (50 × 10\^6 CD8+ CAR+ T cells and 50 × 10\^6 CD4+ CAR+ T cells), on Day 1 (2 to 7 days after completion of Lymphodepleting chemotherapy).
- id
- OG004
- title
- Cohort 5: Primary Central Nervous System Lymphoma
- param Type
- COUNT_OF_PARTICIPANTS
- population Description
- All participants in the JCAR017 treated set with available baseline and Day 29 serum chemistry results. Prespecified to be reported for cohorts 1, 2, 3, 4, and 5 only.
- reporting Status
- POSTED
- time Frame
- At Baseline and Day 29 after JCAR017 infusion
- title
- Number of Participants With Increase From Baseline in Select Serum Chemistry Parameters - Cohorts 1, 2, 3, 4, and 5
- type
- SECONDARY
- unit Of Measure
- Participants
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Preserved source evidence · Not medical advice
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