NCT03434379 · BASELINE

Baseline characteristics

A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma · Source last updated 2023-10-23

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms

counts
group Id
BG000
value
183
group Id
BG001
value
375
group Id
BG002
value
558
units
Participants

groups

description
All participants either in the Global or China population received sorafenib until unacceptable toxicity or loss of clinical benefit as determined by the investigator.
id
BG000
title
Sorafenib - All
description
All participants either in the Global or China population received Atezolizumab + Bevacizumab until unacceptable toxicity or loss of clinical benefit as determined by the investigator.
id
BG001
title
Atezolizumab + Bevacizumab - All
description
Total of all reporting groups
id
BG002
title
Total

measures

classes
categories
measurements
group Id
BG000
spread
10.9
value
64.4
group Id
BG001
spread
11.9
value
62.9
group Id
BG002
spread
11.6
value
63.4
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
spread
12.7
value
57.5
group Id
BG001
spread
12.0
value
55.3
group Id
BG002
spread
12.3
value
56.0
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
dispersion Type
STANDARD_DEVIATION
param Type
MEAN
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Age, Continuous
unit Of Measure
years
classes
categories
measurements
group Id
BG000
value
28
group Id
BG001
value
59
group Id
BG002
value
87
title
Female
measurements
group Id
BG000
value
137
group Id
BG001
value
277
group Id
BG002
value
414
title
Male
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
value
12
group Id
BG001
value
17
group Id
BG002
value
29
title
Female
measurements
group Id
BG000
value
49
group Id
BG001
value
116
group Id
BG002
value
165
title
Male
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
param Type
COUNT_OF_PARTICIPANTS
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Sex: Female, Male
unit Of Measure
Participants
classes
categories
measurements
group Id
BG000
value
4
group Id
BG001
value
9
group Id
BG002
value
13
title
Hispanic or Latino
measurements
group Id
BG000
value
149
group Id
BG001
value
306
group Id
BG002
value
455
title
Not Hispanic or Latino
measurements
group Id
BG000
value
12
group Id
BG001
value
21
group Id
BG002
value
33
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Hispanic or Latino
measurements
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
title
Not Hispanic or Latino
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
param Type
COUNT_OF_PARTICIPANTS
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Ethnicity (NIH/OMB)
unit Of Measure
Participants
classes
categories
measurements
group Id
BG000
value
1
group Id
BG001
value
0
group Id
BG002
value
1
title
American Indian or Alaska Native
measurements
group Id
BG000
value
96
group Id
BG001
value
188
group Id
BG002
value
284
title
Asian
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Native Hawaiian or Other Pacific Islander
measurements
group Id
BG000
value
4
group Id
BG001
value
6
group Id
BG002
value
10
title
Black or African American
measurements
group Id
BG000
value
52
group Id
BG001
value
123
group Id
BG002
value
175
title
White
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
More than one race
measurements
group Id
BG000
value
12
group Id
BG001
value
19
group Id
BG002
value
31
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
American Indian or Alaska Native
measurements
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
title
Asian
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Native Hawaiian or Other Pacific Islander
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Black or African American
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
White
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
More than one race
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
param Type
COUNT_OF_PARTICIPANTS
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Race (NIH/OMB)
unit Of Measure
Participants

population Description

The intent-to-treat (ITT) population included 558 participants (All) with 501 in the Global population. An additional 57 participants enrolled in the China Extension. The China population included 137 Chinese participants from the Global population plus 57 participants from the China Extension. The Global population and China population were analyzed separately.

Complete source fields

denoms

counts
group Id
BG000
value
183
group Id
BG001
value
375
group Id
BG002
value
558
units
Participants

groups

description
All participants either in the Global or China population received sorafenib until unacceptable toxicity or loss of clinical benefit as determined by the investigator.
id
BG000
title
Sorafenib - All
description
All participants either in the Global or China population received Atezolizumab + Bevacizumab until unacceptable toxicity or loss of clinical benefit as determined by the investigator.
id
BG001
title
Atezolizumab + Bevacizumab - All
description
Total of all reporting groups
id
BG002
title
Total

measures

classes
categories
measurements
group Id
BG000
spread
10.9
value
64.4
group Id
BG001
spread
11.9
value
62.9
group Id
BG002
spread
11.6
value
63.4
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
spread
12.7
value
57.5
group Id
BG001
spread
12.0
value
55.3
group Id
BG002
spread
12.3
value
56.0
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
dispersion Type
STANDARD_DEVIATION
param Type
MEAN
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Age, Continuous
unit Of Measure
years
classes
categories
measurements
group Id
BG000
value
28
group Id
BG001
value
59
group Id
BG002
value
87
title
Female
measurements
group Id
BG000
value
137
group Id
BG001
value
277
group Id
BG002
value
414
title
Male
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
value
12
group Id
BG001
value
17
group Id
BG002
value
29
title
Female
measurements
group Id
BG000
value
49
group Id
BG001
value
116
group Id
BG002
value
165
title
Male
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
param Type
COUNT_OF_PARTICIPANTS
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Sex: Female, Male
unit Of Measure
Participants
classes
categories
measurements
group Id
BG000
value
4
group Id
BG001
value
9
group Id
BG002
value
13
title
Hispanic or Latino
measurements
group Id
BG000
value
149
group Id
BG001
value
306
group Id
BG002
value
455
title
Not Hispanic or Latino
measurements
group Id
BG000
value
12
group Id
BG001
value
21
group Id
BG002
value
33
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Hispanic or Latino
measurements
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
title
Not Hispanic or Latino
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
param Type
COUNT_OF_PARTICIPANTS
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Ethnicity (NIH/OMB)
unit Of Measure
Participants
classes
categories
measurements
group Id
BG000
value
1
group Id
BG001
value
0
group Id
BG002
value
1
title
American Indian or Alaska Native
measurements
group Id
BG000
value
96
group Id
BG001
value
188
group Id
BG002
value
284
title
Asian
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Native Hawaiian or Other Pacific Islander
measurements
group Id
BG000
value
4
group Id
BG001
value
6
group Id
BG002
value
10
title
Black or African American
measurements
group Id
BG000
value
52
group Id
BG001
value
123
group Id
BG002
value
175
title
White
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
More than one race
measurements
group Id
BG000
value
12
group Id
BG001
value
19
group Id
BG002
value
31
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
165
group Id
BG001
value
336
group Id
BG002
value
501
units
Participants
title
Global
categories
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
American Indian or Alaska Native
measurements
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
title
Asian
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Native Hawaiian or Other Pacific Islander
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Black or African American
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
White
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
More than one race
measurements
group Id
BG000
value
0
group Id
BG001
value
0
group Id
BG002
value
0
title
Unknown or Not Reported
denoms
counts
group Id
BG000
value
61
group Id
BG001
value
133
group Id
BG002
value
194
units
Participants
title
China
param Type
COUNT_OF_PARTICIPANTS
population Description
The Global population included 501 participants. The China population included 57 participants enrolled during the China Extension plus 137 Chinese participants from the Global population.
title
Race (NIH/OMB)
unit Of Measure
Participants

population Description

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice