Participant flow

Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN · Source last updated 2026-09-04

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups

1. description

   Participants received IMGN632 at a dose of 0.015 milligrams (mg)/kilogram (kg) via intravenous (IV) infusion on Day 1 of each 21-day cycle.

   id

   FG000

   title

   Dose Escalation - Schedule A: IMGN632 0.015 mg/kg

2. description

   Participants received IMGN632 at a dose of 0.045 mg/kg via IV infusion on Day 1 of each 21-day cycle.

   id

   FG001

   title

   Dose Escalation - Schedule A: IMGN632 0.045 mg/kg

3. description

   Participants received IMGN632 at a dose of 0.09 mg/kg via IV infusion on Day 1 of each 21-day cycle.

   id

   FG002

   title

   Dose Escalation - Schedule A: IMGN632 0.09 mg/kg

4. description

   Participants received IMGN632 at a dose of 0.18 mg/kg via IV infusion on Day 1 of each 21-day cycle.

   id

   FG003

   title

   Dose Escalation - Schedule A: IMGN632 0.18 mg/kg

5. description

   Participants received IMGN632 at a dose of 0.3 mg/kg via IV infusion on Day 1 of each 21-day cycle.

   id

   FG004

   title

   Dose Escalation - Schedule A: IMGN632 0.3 mg/kg

6. description

   Participants received IMGN632 at a dose of 0.45 mg/kg via IV infusion on Day 1 of each 21-day cycle.

   id

   FG005

   title

   Dose Escalation - Schedule A: IMGN632 0.45 mg/kg

7. description

   Participants received IMGN632 at a dose of 0.015 mg/kg via IV infusion on Days 1, 4, and 8 of each 21-day cycle.

   id

   FG006

   title

   Dose Escalation - Schedule B: IMGN632 0.015 mg/kg

8. description

   Participants received IMGN632 at a dose of 0.03 mg/kg via IV infusion on Days 1, 4, and 8 of each 21-day cycle.

   id

   FG007

   title

   Dose Escalation - Schedule B: IMGN632 0.03 mg/kg

9. description

   Participants received IMGN632 at a dose of 0.06 mg/kg via IV infusion on Days 1, 4, and 8 of each 21-day cycle.

   id

   FG008

   title

   Dose Escalation - Schedule B: IMGN632 0.06 mg/kg

10. description

    Participants received IMGN632 at a dose of 0.045 mg/kg via IV infusion on Day 1 of each 21-day cycle.

    id

    FG009

    title

    Dose Expansion - Schedule A: IMGN632 0.045 mg/kg

11. description

    Participants received IMGN632 at a dose of 0.09 mg/kg via IV infusion on Day 1 of each 21-day cycle.

    id

    FG010

    title

    Dose Expansion - Schedule A: IMGN632 0.09 mg/kg

periods

1. drop Withdraws

   1. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         1

      10. group Id

          FG009

          num Subjects

          2

      11. group Id

          FG010

          num Subjects

          1

      type

      Withdrawal by Subject

   2. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         0

      10. group Id

          FG009

          num Subjects

          3

      11. group Id

          FG010

          num Subjects

          0

      type

      Lost to Follow-up

   3. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         1

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         1

      10. group Id

          FG009

          num Subjects

          0

      11. group Id

          FG010

          num Subjects

          0

      type

      Sponsor Decision

   4. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         0

      10. group Id

          FG009

          num Subjects

          1

      11. group Id

          FG010

          num Subjects

          0

      type

      Investigator Decision

   5. reasons

      1. group Id

         FG000

         num Subjects

         2

      2. group Id

         FG001

         num Subjects

         10

      3. group Id

         FG002

         num Subjects

         12

      4. group Id

         FG003

         num Subjects

         7

      5. group Id

         FG004

         num Subjects

         5

      6. group Id

         FG005

         num Subjects

         2

      7. group Id

         FG006

         num Subjects

         3

      8. group Id

         FG007

         num Subjects

         6

      9. group Id

         FG008

         num Subjects

         12

      10. group Id

          FG009

          num Subjects

          76

      11. group Id

          FG010

          num Subjects

          9

      type

      Death

   6. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         0

      10. group Id

          FG009

          num Subjects

          1

      11. group Id

          FG010

          num Subjects

          0

      type

      Other than Specified

   7. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         0

      10. group Id

          FG009

          num Subjects

          13

      11. group Id

          FG010

          num Subjects

          0

      type

      Ongoing in Trial at Time of Data Cutoff

   milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         12

      3. group Id

         FG002

         num Subjects

         13

      4. group Id

         FG003

         num Subjects

         7

      5. group Id

         FG004

         num Subjects

         5

      6. group Id

         FG005

         num Subjects

         2

      7. group Id

         FG006

         num Subjects

         3

      8. group Id

         FG007

         num Subjects

         6

      9. group Id

         FG008

         num Subjects

         14

      10. group Id

          FG009

          num Subjects

          104

      11. group Id

          FG010

          num Subjects

          10

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         12

      3. group Id

         FG002

         num Subjects

         13

      4. group Id

         FG003

         num Subjects

         7

      5. group Id

         FG004

         num Subjects

         5

      6. group Id

         FG005

         num Subjects

         2

      7. group Id

         FG006

         num Subjects

         3

      8. group Id

         FG007

         num Subjects

         6

      9. group Id

         FG008

         num Subjects

         14

      10. group Id

          FG009

          num Subjects

          104

      11. group Id

          FG010

          num Subjects

          10

      type

      Received at least 1 dose of study drug

   3. achievements

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         1

      3. group Id

         FG002

         num Subjects

         1

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      7. group Id

         FG006

         num Subjects

         0

      8. group Id

         FG007

         num Subjects

         0

      9. group Id

         FG008

         num Subjects

         0

      10. group Id

          FG009

          num Subjects

          8

      11. group Id

          FG010

          num Subjects

          0

      type

      COMPLETED

   4. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         11

      3. group Id

         FG002

         num Subjects

         12

      4. group Id

         FG003

         num Subjects

         7

      5. group Id

         FG004

         num Subjects

         5

      6. group Id

         FG005

         num Subjects

         2

      7. group Id

         FG006

         num Subjects

         3

      8. group Id

         FG007

         num Subjects

         6

      9. group Id

         FG008

         num Subjects

         14

      10. group Id

          FG009

          num Subjects

          96

      11. group Id

          FG010

          num Subjects

          10

      type

      NOT COMPLETED

   title

   Overall Study

pre Assignment Details

The study is ongoing and reports data up to the primary analysis data cut-off date (up to approximately 81 months).

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Independent clinical review pending · Not medical advice