Skip to content
Triangle logo TriangleGet started
← Full study record

NCT03239145 · BASELINE

Baseline characteristics

Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor · Source last updated 2026-07-01

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      3
    2. group Id
      BG001
      value
      40
    3. group Id
      BG002
      value
      11
    4. group Id
      BG003
      value
      4
    5. group Id
      BG004
      value
      58
    units
    Participants
groups
  1. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 15 mg/kg weekly.
    id
    BG000
    title
    [Dose Level I] Pembrolizumab + Trebananib
  2. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 30 mg/kg weekly.
    id
    BG001
    title
    [Dose Level II] Pembrolizumab + Trebananib (Colorectal)
  3. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 30 mg/kg weekly.
    id
    BG002
    title
    [Dose Level II] Pembrolizumab + Trebananib (Ovarian)
  4. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 30 mg/kg weekly.
    id
    BG003
    title
    [Dose Level II] Pembrolizumab + Trebananib (Renal Cell Carcinoma)
  5. description
    Total of all reporting groups
    id
    BG004
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          32.3
          upper Limit
          57.0
          value
          40.8
        2. group Id
          BG001
          lower Limit
          29.7
          upper Limit
          74.3
          value
          53.8
        3. group Id
          BG002
          lower Limit
          51.9
          upper Limit
          74.6
          value
          63.6
        4. group Id
          BG003
          lower Limit
          51.7
          upper Limit
          62.5
          value
          56.3
        5. group Id
          BG004
          lower Limit
          29.7
          upper Limit
          74.6
          value
          55.4
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          17
        3. group Id
          BG002
          value
          11
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          32
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          26
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          1
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          32
        3. group Id
          BG002
          value
          11
        4. group Id
          BG003
          value
          4
        5. group Id
          BG004
          value
          50
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          7
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          7
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          6
      title
      Asian
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          3
      title
      Black or African American
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          1
      title
      Other
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          32
        3. group Id
          BG002
          value
          9
        4. group Id
          BG003
          value
          4
        5. group Id
          BG004
          value
          48
      title
      White
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          26
        3. group Id
          BG002
          value
          5
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          34
      title
      Performance Status 0
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          6
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          24
      title
      Performance Status 1
    description
    The Eastern Cooperative Oncology Group (ECOG) Performance Status is a scale used to assess a patient's level of functioning and ability to perform daily activities, and to evaluate how a disease affects a patient's quality of life. It is widely used in oncology clinical trials to determine eligibility, stratify patients, and assess prognosis. 0 - Fully active; able to carry on all pre-disease activities without restriction. 1 - Restricted in physically strenuous activity but ambulatory and able to carry out light or sedentary work (e.g., light housework, office work).
    param Type
    COUNT_OF_PARTICIPANTS
    title
    ECOG Performance Status
    unit Of Measure
    Participants
population Description
Per protocol, patient characteristics will be summarized by cohort; the dose escalation and dose expansion data could be combined for patients with the same cancer type and the same treatment doses. Baseline characteristics are summarized for treated participants.
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      3
    2. group Id
      BG001
      value
      40
    3. group Id
      BG002
      value
      11
    4. group Id
      BG003
      value
      4
    5. group Id
      BG004
      value
      58
    units
    Participants
groups
  1. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 15 mg/kg weekly.
    id
    BG000
    title
    [Dose Level I] Pembrolizumab + Trebananib
  2. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 30 mg/kg weekly.
    id
    BG001
    title
    [Dose Level II] Pembrolizumab + Trebananib (Colorectal)
  3. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 30 mg/kg weekly.
    id
    BG002
    title
    [Dose Level II] Pembrolizumab + Trebananib (Ovarian)
  4. description
    Participants received pembrolizumab 200 mg administered intravenously every 3 weeks in combination with trebananib administered intravenously at 30 mg/kg weekly.
    id
    BG003
    title
    [Dose Level II] Pembrolizumab + Trebananib (Renal Cell Carcinoma)
  5. description
    Total of all reporting groups
    id
    BG004
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          32.3
          upper Limit
          57.0
          value
          40.8
        2. group Id
          BG001
          lower Limit
          29.7
          upper Limit
          74.3
          value
          53.8
        3. group Id
          BG002
          lower Limit
          51.9
          upper Limit
          74.6
          value
          63.6
        4. group Id
          BG003
          lower Limit
          51.7
          upper Limit
          62.5
          value
          56.3
        5. group Id
          BG004
          lower Limit
          29.7
          upper Limit
          74.6
          value
          55.4
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          17
        3. group Id
          BG002
          value
          11
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          32
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          26
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          1
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          32
        3. group Id
          BG002
          value
          11
        4. group Id
          BG003
          value
          4
        5. group Id
          BG004
          value
          50
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          7
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          7
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          6
      title
      Asian
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          3
      title
      Black or African American
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          1
      title
      Other
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          32
        3. group Id
          BG002
          value
          9
        4. group Id
          BG003
          value
          4
        5. group Id
          BG004
          value
          48
      title
      White
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          26
        3. group Id
          BG002
          value
          5
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          34
      title
      Performance Status 0
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          6
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          24
      title
      Performance Status 1
    description
    The Eastern Cooperative Oncology Group (ECOG) Performance Status is a scale used to assess a patient's level of functioning and ability to perform daily activities, and to evaluate how a disease affects a patient's quality of life. It is widely used in oncology clinical trials to determine eligibility, stratify patients, and assess prognosis. 0 - Fully active; able to carry on all pre-disease activities without restriction. 1 - Restricted in physically strenuous activity but ambulatory and able to carry out light or sedentary work (e.g., light housework, office work).
    param Type
    COUNT_OF_PARTICIPANTS
    title
    ECOG Performance Status
    unit Of Measure
    Participants
population Description
Per protocol, patient characteristics will be summarized by cohort; the dose escalation and dose expansion data could be combined for patients with the same cancer type and the same treatment doses. Baseline characteristics are summarized for treated participants.

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice