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NCT03233204 · OUTCOME

Pharmacokinetics (PK) of Olaparib, Area Under the Curve (AUC)

Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) · Source last updated 2024-12-11

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
mcg*hr/ml
Interval / dispersion
Standard Deviation
Time frame
Up to day 8 of cycle 1

What was measured

The mean (sd) of the AUC.

Analysis population: 3 of the 6 enrolled patients had PK data available for analysis

Groups in this outcome

Treatment (Olaparib)

Patients receive olaparib PO BID on days 1-28. Cycles repeat every 28 days for 2 years in the absence of disease progression or unacceptable toxicity.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Treatment (Olaparib)3

Reported measurements

Source class 1
Values in mcg*hr/ml · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Treatment (Olaparib)48.827.8Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        27.8
        value
        48.8
denoms
  1. counts
    1. group Id
      OG000
      value
      3
    units
    Participants
description
The mean (sd) of the AUC.
dispersion Type
Standard Deviation
groups
  1. description
    Patients receive olaparib PO BID on days 1-28. Cycles repeat every 28 days for 2 years in the absence of disease progression or unacceptable toxicity.
    id
    OG000
    title
    Treatment (Olaparib)
param Type
MEAN
population Description
3 of the 6 enrolled patients had PK data available for analysis
reporting Status
POSTED
time Frame
Up to day 8 of cycle 1
title
Pharmacokinetics (PK) of Olaparib, Area Under the Curve (AUC)
type
SECONDARY
unit Of Measure
mcg*hr/ml

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice