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NCT03132922 · OUTCOME

Progression Free Survival (PFS)

MAGE-A4ᶜ¹º³²T for Multi-Tumor · Source last updated 2026-06-04

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
Weeks
Interval / dispersion
95% Confidence Interval
Time frame
From afamitresgene autoleucel infusion until first documented PD or death due to any cause, whichever comes first, or censored date.

What was measured

PFS was defined as the time from the date of the first T-cell infusion to the first date of the radiological PD or death date (due to any reason), whichever event was earlier.

Analysis population: Participants who received afamitresgene autoleucel or LDR/ afamitresgene autoleucel

Groups in this outcome

Afamitresgene Autoleucel, Group 1

Participants who received afamitresgene autoleucel 0.1x10\^9 transduced cells

Afamitresgene Autoleucel, Group 2

Participants who received afamitresgene autoleucel 0.5-1.2x10\^9 transduced cells

Afamitresgene Autoleucel, Group 3 + Expansion

Participants who received afamitresgene autoleucel 1.2-10x10\^9 transduced cells

Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel

Participants who received LDR in combination with lymphodepletion chemotherapy followed by the afamitresgene autoleucel infusion.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Afamitresgene Autoleucel, Group 13
Afamitresgene Autoleucel, Group 23
Afamitresgene Autoleucel, Group 3 + Expansion32
Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel4

Reported measurements

Source class 1
Values in Weeks · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Afamitresgene Autoleucel, Group 18.9Not reported5.57112.286Not reported
Afamitresgene Autoleucel, Group 212.1Not reported10.85712.143Not reported
Afamitresgene Autoleucel, Group 3 + Expansion12.4Not reported10.00020.429Not reported
Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel19.143Not reported11.571NAUpper confidence interval bounds were not estimable in some arms due to censoring
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.571
        upper Limit
        12.286
        value
        8.9
      2. group Id
        OG001
        lower Limit
        10.857
        upper Limit
        12.143
        value
        12.1
      3. group Id
        OG002
        lower Limit
        10.000
        upper Limit
        20.429
        value
        12.4
      4. comment
        Upper confidence interval bounds were not estimable in some arms due to censoring
        group Id
        OG003
        lower Limit
        11.571
        upper Limit
        NA
        value
        19.143
denoms
  1. counts
    1. group Id
      OG000
      value
      3
    2. group Id
      OG001
      value
      3
    3. group Id
      OG002
      value
      32
    4. group Id
      OG003
      value
      4
    units
    Participants
description
PFS was defined as the time from the date of the first T-cell infusion to the first date of the radiological PD or death date (due to any reason), whichever event was earlier.
dispersion Type
95% Confidence Interval
groups
  1. description
    Participants who received afamitresgene autoleucel 0.1x10\^9 transduced cells
    id
    OG000
    title
    Afamitresgene Autoleucel, Group 1
  2. description
    Participants who received afamitresgene autoleucel 0.5-1.2x10\^9 transduced cells
    id
    OG001
    title
    Afamitresgene Autoleucel, Group 2
  3. description
    Participants who received afamitresgene autoleucel 1.2-10x10\^9 transduced cells
    id
    OG002
    title
    Afamitresgene Autoleucel, Group 3 + Expansion
  4. description
    Participants who received LDR in combination with lymphodepletion chemotherapy followed by the afamitresgene autoleucel infusion.
    id
    OG003
    title
    Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel
param Type
MEDIAN
population Description
Participants who received afamitresgene autoleucel or LDR/ afamitresgene autoleucel
reporting Status
POSTED
time Frame
From afamitresgene autoleucel infusion until first documented PD or death due to any cause, whichever comes first, or censored date.
title
Progression Free Survival (PFS)
type
SECONDARY
unit Of Measure
Weeks

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice