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NCT03132922 · OUTCOME

Duration of Response (DoR)

MAGE-A4ᶜ¹º³²T for Multi-Tumor · Source last updated 2026-06-04

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
Weeks
Interval / dispersion
95% Confidence Interval
Time frame
From initial confirmed response (DR or PR) until PD or censored date. is defined as all participants who had not experienced the event of interest (i.e. ongoing, event free) at the time of the data cut off (used for the analysis).

What was measured

DoR was measured from the first CR/PR (whichever was first recorded) until the first date of progressive disease.

Analysis population: No patients in Groups 1 and 2 achieved objective response.

Groups in this outcome

Afamitresgene Autoleucel, Group 1

Participants who received afamitresgene autoleucel 0.1x10\^9 transduced cells

Afamitresgene Autoleucel, Group 2

Participants who received afamitresgene autoleucel 0.5-1.2x10\^9 transduced cells

Afamitresgene Autoleucel Group 3 + Expansion

Participants who received afamitresgene autoleucel 1.2-10x10\^9 transduced cells

Substudy: Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel

Participants who received LDR in combination with lymphodepletion chemotherapy followed by the afamitresgene autoleucel infusion (1.2-10x10\^9 transduced cells).

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Afamitresgene Autoleucel, Group 10
Afamitresgene Autoleucel, Group 20
Afamitresgene Autoleucel Group 3 + Expansion9
Substudy: Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel1

Reported measurements

Source class 1
Values in Weeks · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Afamitresgene Autoleucel Group 3 + Expansion25.6Not reported12.286NAUpper confidence interval bounds were not estimable due to censoring
Substudy: Low Dose Radiation (LDR) in Combination With Afamitresgene AutoleucelNANot reportedNANAMedian and confidence intervals were not etimable due to censoring
Complete source fields
classes
  1. categories
    1. measurements
      1. comment
        Upper confidence interval bounds were not estimable due to censoring
        group Id
        OG002
        lower Limit
        12.286
        upper Limit
        NA
        value
        25.6
      2. comment
        Median and confidence intervals were not etimable due to censoring
        group Id
        OG003
        lower Limit
        NA
        upper Limit
        NA
        value
        NA
denoms
  1. counts
    1. group Id
      OG000
      value
      0
    2. group Id
      OG001
      value
      0
    3. group Id
      OG002
      value
      9
    4. group Id
      OG003
      value
      1
    units
    Participants
description
DoR was measured from the first CR/PR (whichever was first recorded) until the first date of progressive disease.
dispersion Type
95% Confidence Interval
groups
  1. description
    Participants who received afamitresgene autoleucel 0.1x10\^9 transduced cells
    id
    OG000
    title
    Afamitresgene Autoleucel, Group 1
  2. description
    Participants who received afamitresgene autoleucel 0.5-1.2x10\^9 transduced cells
    id
    OG001
    title
    Afamitresgene Autoleucel, Group 2
  3. description
    Participants who received afamitresgene autoleucel 1.2-10x10\^9 transduced cells
    id
    OG002
    title
    Afamitresgene Autoleucel Group 3 + Expansion
  4. description
    Participants who received LDR in combination with lymphodepletion chemotherapy followed by the afamitresgene autoleucel infusion (1.2-10x10\^9 transduced cells).
    id
    OG003
    title
    Substudy: Low Dose Radiation (LDR) in Combination With Afamitresgene Autoleucel
param Type
MEAN
population Description
No patients in Groups 1 and 2 achieved objective response.
reporting Status
POSTED
time Frame
From initial confirmed response (DR or PR) until PD or censored date. is defined as all participants who had not experienced the event of interest (i.e. ongoing, event free) at the time of the data cut off (used for the analysis).
title
Duration of Response (DoR)
type
SECONDARY
unit Of Measure
Weeks

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice