Skip to content
Triangle logo TriangleGet started
← Full study record

NCT03112603 · BASELINE

Baseline characteristics

A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3) · Source last updated 2025-08-12

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      165
    2. group Id
      BG001
      value
      164
    3. group Id
      BG002
      value
      329
    units
    Participants
groups
  1. description
    Ruxolitinib was administered orally twice per day at a dose of 10 milligrams (mg).
    id
    BG000
    title
    Ruxolitinib
  2. description
    Participants received best available therapies (BATs), including, but not limited to, extracorporeal photopheresis (ECP), low-dose methotrexate (MTX), mycophenolate mofetil (MMF), mTOR inhibitors (everolimus or sirolimus), infliximab, rituximab, pentostatin, imatinib, and ibrutinib based on the investigator's decision.
    id
    BG001
    title
    Best Available Therapy
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          15.68
          value
          45.9
        2. group Id
          BG001
          spread
          16.17
          value
          47.2
        3. group Id
          BG002
          spread
          15.92
          value
          46.5
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          56
        2. group Id
          BG001
          value
          72
        3. group Id
          BG002
          value
          128
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          109
        2. group Id
          BG001
          value
          92
        3. group Id
          BG002
          value
          201
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          116
        2. group Id
          BG001
          value
          132
        3. group Id
          BG002
          value
          248
        title
        White
      2. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        title
        Black or African American
      3. measurements
        1. group Id
          BG000
          value
          33
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          54
        title
        Asian
      4. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        title
        American Indian or Alaska Native
      5. measurements
        1. group Id
          BG000
          value
          9
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          13
        title
        Other
      6. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          7
        3. group Id
          BG002
          value
          10
        title
        Unknown
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          13
        2. group Id
          BG001
          value
          13
        3. group Id
          BG002
          value
          26
        title
        Hispanic/Latino
      2. measurements
        1. group Id
          BG000
          value
          118
        2. group Id
          BG001
          value
          115
        3. group Id
          BG002
          value
          233
        title
        Not Hispanic/Latino
      3. measurements
        1. group Id
          BG000
          value
          26
        2. group Id
          BG001
          value
          25
        3. group Id
          BG002
          value
          51
        title
        Not Reported
      4. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          11
        3. group Id
          BG002
          value
          19
        title
        Unknown
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          39
        2. group Id
          BG001
          value
          42
        3. group Id
          BG002
          value
          81
        title
        0
      2. measurements
        1. group Id
          BG000
          value
          92
        2. group Id
          BG001
          value
          82
        3. group Id
          BG002
          value
          174
        title
        1
      3. measurements
        1. group Id
          BG000
          value
          22
        2. group Id
          BG001
          value
          22
        3. group Id
          BG002
          value
          44
        title
        2
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          2
        title
        3
      5. measurements
        1. group Id
          BG000
          value
          12
        2. group Id
          BG001
          value
          16
        3. group Id
          BG002
          value
          28
        title
        Missing
    description
    The Eastern Cooperative Oncology Group (ECOG) Performance Score has 6 grades (0-5). 0 = Fully active, able to carry out all pre-disease activities; 1 = Restricted in strenuous activity but ambulatory and able to carry out work of light or sedentary nature; 2 = Ambulatory and capable of all self-care but unable to carry out work activities. Active about 50% of waking hours; 3 = Capable of limited self-care, confined to bed/chair more than 50% of waking hours; 4 = Completely disabled; cannot carry on self-care. Totally confined to bed/chair. 5 = Death.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    ECOG Performance Status
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      165
    2. group Id
      BG001
      value
      164
    3. group Id
      BG002
      value
      329
    units
    Participants
groups
  1. description
    Ruxolitinib was administered orally twice per day at a dose of 10 milligrams (mg).
    id
    BG000
    title
    Ruxolitinib
  2. description
    Participants received best available therapies (BATs), including, but not limited to, extracorporeal photopheresis (ECP), low-dose methotrexate (MTX), mycophenolate mofetil (MMF), mTOR inhibitors (everolimus or sirolimus), infliximab, rituximab, pentostatin, imatinib, and ibrutinib based on the investigator's decision.
    id
    BG001
    title
    Best Available Therapy
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          15.68
          value
          45.9
        2. group Id
          BG001
          spread
          16.17
          value
          47.2
        3. group Id
          BG002
          spread
          15.92
          value
          46.5
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          56
        2. group Id
          BG001
          value
          72
        3. group Id
          BG002
          value
          128
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          109
        2. group Id
          BG001
          value
          92
        3. group Id
          BG002
          value
          201
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          116
        2. group Id
          BG001
          value
          132
        3. group Id
          BG002
          value
          248
        title
        White
      2. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        title
        Black or African American
      3. measurements
        1. group Id
          BG000
          value
          33
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          54
        title
        Asian
      4. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        title
        American Indian or Alaska Native
      5. measurements
        1. group Id
          BG000
          value
          9
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          13
        title
        Other
      6. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          7
        3. group Id
          BG002
          value
          10
        title
        Unknown
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          13
        2. group Id
          BG001
          value
          13
        3. group Id
          BG002
          value
          26
        title
        Hispanic/Latino
      2. measurements
        1. group Id
          BG000
          value
          118
        2. group Id
          BG001
          value
          115
        3. group Id
          BG002
          value
          233
        title
        Not Hispanic/Latino
      3. measurements
        1. group Id
          BG000
          value
          26
        2. group Id
          BG001
          value
          25
        3. group Id
          BG002
          value
          51
        title
        Not Reported
      4. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          11
        3. group Id
          BG002
          value
          19
        title
        Unknown
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          39
        2. group Id
          BG001
          value
          42
        3. group Id
          BG002
          value
          81
        title
        0
      2. measurements
        1. group Id
          BG000
          value
          92
        2. group Id
          BG001
          value
          82
        3. group Id
          BG002
          value
          174
        title
        1
      3. measurements
        1. group Id
          BG000
          value
          22
        2. group Id
          BG001
          value
          22
        3. group Id
          BG002
          value
          44
        title
        2
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          2
        title
        3
      5. measurements
        1. group Id
          BG000
          value
          12
        2. group Id
          BG001
          value
          16
        3. group Id
          BG002
          value
          28
        title
        Missing
    description
    The Eastern Cooperative Oncology Group (ECOG) Performance Score has 6 grades (0-5). 0 = Fully active, able to carry out all pre-disease activities; 1 = Restricted in strenuous activity but ambulatory and able to carry out work of light or sedentary nature; 2 = Ambulatory and capable of all self-care but unable to carry out work activities. Active about 50% of waking hours; 3 = Capable of limited self-care, confined to bed/chair more than 50% of waking hours; 4 = Completely disabled; cannot carry on self-care. Totally confined to bed/chair. 5 = Death.
    param Type
    COUNT_OF_PARTICIPANTS
    title
    ECOG Performance Status
    unit Of Measure
    Participants

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice