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NCT03108131 · OUTCOME

Overall Survival

Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors · Source last updated 2025-05-28

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
months
Interval / dispersion
95% Confidence Interval
Time frame
3 years

What was measured

Overall survival (OS) is defined as the time from randomization to death

Analysis population: 2 of the patients was not included in the analysis of PFS because their surgical cancellations were unrelated to progressive disease.

Groups in this outcome

Small Bowel Adenocarcinoma

Must be refractory or intolerant to at least one line of 5FU-based chemotherapy for metastatic disease and must not have clinically symptomatic malignant small bowel obstruction. Cobimetinib (60 mgorally once daily for days 1 - 21) and atezolizumab (840 mg intravenously every 2 weeks) every 28-day cycle.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Small Bowel Adenocarcinoma18

Reported measurements

Source class 1
Values in months · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Small Bowel Adenocarcinoma8.8Not reported5.612Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.6
        upper Limit
        12
        value
        8.8
denoms
  1. counts
    1. group Id
      OG000
      value
      18
    units
    Participants
description
Overall survival (OS) is defined as the time from randomization to death
dispersion Type
95% Confidence Interval
groups
  1. description
    Must be refractory or intolerant to at least one line of 5FU-based chemotherapy for metastatic disease and must not have clinically symptomatic malignant small bowel obstruction. Cobimetinib (60 mgorally once daily for days 1 - 21) and atezolizumab (840 mg intravenously every 2 weeks) every 28-day cycle.
    id
    OG000
    title
    Small Bowel Adenocarcinoma
param Type
MEDIAN
population Description
2 of the patients was not included in the analysis of PFS because their surgical cancellations were unrelated to progressive disease.
reporting Status
POSTED
time Frame
3 years
title
Overall Survival
type
SECONDARY
unit Of Measure
months

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice