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NCT03105336 · OUTCOME

Levels of Serum Ferritin, Serum ICAM-1, Serum IL-2 R Alpha, Serum Perforin and Serum VCAM-1

A Study of Axicabtagene Ciloleucel in Participants With Relapsed/Refractory Indolent Non-Hodgkin Lymphoma · Source last updated 2025-12-23

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: MEAN
Unit: ng/L
Interval / dispersion: Standard Deviation
Time frame: Baseline (at enrollment), predose: Day 0, postdose: Day 3, Day 7, Week 2, Week 4

What was measured

Serum analytes: Serum Ferritin, Serum intercellular adhesion molecule-1 (ICAM-1), Serum interleukin-2 receptor (IL-2 R) alpha, Serum Perforin and Serum vascular cell adhesion molecule-1 (VCAM-1).

Analysis population: Participants in the Safety Analysis Set with available data were analyzed.

Groups in this outcome

Axicabtagene Ciloleucel (Follicular Lymphoma)

Participants with r/r B-cell iNHL subtype of FL received the following treatment during the study: * A conditioning chemotherapy regimen of fludarabine 30 mg/m\^2/day IV and cyclophosphamide 500 mg/m\^2/day IV for 3 days (Day -5 to Day -3). * A single IV infusion at a target dose of 2×10\^6 anti-CD19 CAR transduced autologous T cells/kg on Day 0.

Axicabtagene Ciloleucel (Marginal Zone Lymphoma)

Participants with r/r B-cell iNHL subtype of MZL received the following treatment during the study: * A conditioning chemotherapy regimen of fludarabine 30 mg/m\^2/day IV and cyclophosphamide 500 mg/m\^2/day IV for 3 days (Day -5 to Day -3). * A single IV infusion at a target dose of 2×10\^6 anti-CD19 CAR transduced autologous T cells/kg on Day 0.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	124
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Reported measurements

Serum Ferritin on Baseline

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	122
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	330.54	398.03	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	207.63	218.42	Not reported	Not reported	Not reported

Serum Ferritin on Day 0

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	121
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	503.99	502.07	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	398.49	337.82	Not reported	Not reported	Not reported

Serum Ferritin on Day 3

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	106
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	27

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	541.51	457.18	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	487.39	414.90	Not reported	Not reported	Not reported

Serum Ferritin on Day 7

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	123
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	779.75	782.98	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	1820.38	4837.56	Not reported	Not reported	Not reported

Serum Ferritin on Week 2

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	113
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	26

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	741.76	787.70	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	959.49	1546.07	Not reported	Not reported	Not reported

Serum Ferritin on Week 4

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	118
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	528.83	605.94	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	478.47	459.54	Not reported	Not reported	Not reported

Serum ICAM-1 on Baseline

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	122
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	876.99	833.80	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	709.71	430.14	Not reported	Not reported	Not reported

Serum ICAM-1 on Day 0

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	121
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	834.87	854.35	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	642.60	365.92	Not reported	Not reported	Not reported

Serum ICAM-1 on Day 3

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	106
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	27

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	964.45	904.79	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	792.47	621.84	Not reported	Not reported	Not reported

Serum ICAM-1 on Day 7

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	123
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	924.99	846.56	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	934.02	618.96	Not reported	Not reported	Not reported

Serum ICAM-1 on Week 2

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	113
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	26

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	695.15	605.03	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	696.77	438.71	Not reported	Not reported	Not reported

Serum ICAM-1 on Week 4

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	118
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	671.32	656.46	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	614.92	487.67	Not reported	Not reported	Not reported

Serum IL-2 R alpha on Baseline

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	122
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	8.52	12.15	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	5.62	7.50	Not reported	Not reported	Not reported

Serum IL-2 R alpha on Day 0

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	121
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	8.39	9.10	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	4.91	4.12	Not reported	Not reported	Not reported

Serum IL-2 R alpha on Day 3

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	106
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	27

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	9.96	11.53	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	7.31	5.68	Not reported	Not reported	Not reported

Serum IL-2 R alpha on Day 7

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	123
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	14.42	15.10	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	19.78	20.82	Not reported	Not reported	Not reported

Serum IL-2 R alpha on Week 2

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	113
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	26

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	7.16	8.27	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	10.40	12.26	Not reported	Not reported	Not reported

Serum IL-2 R alpha on Week 4

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	118
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	3.39	3.34	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	4.02	3.67	Not reported	Not reported	Not reported

Serum Perforin on Baseline

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	122
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	13.26	7.20	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	13.58	18.33	Not reported	Not reported	Not reported

Serum Perforin on Day 0

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	121
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	2.56	1.85	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	3.30	9.11	Not reported	Not reported	Not reported

Serum Perforin on Day 3

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	106
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	27

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	3.87	3.36	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	4.71	13.53	Not reported	Not reported	Not reported

Serum Perforin on Day 7

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	124
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	8.49	10.54	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	6.60	7.99	Not reported	Not reported	Not reported

Serum Perforin on Week 2

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	113
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	26

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	8.06	6.90	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	6.01	6.77	Not reported	Not reported	Not reported

Serum Perforin on Week 4

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	118
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	14.56	11.92	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	12.32	12.08	Not reported	Not reported	Not reported

Serum VCAM-1 on Baseline

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	122
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	1499.37	1637.98	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	1282.81	1232.76	Not reported	Not reported	Not reported

Serum VCAM-1 on Day 0

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	121
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	1182.41	1166.58	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	931.58	709.94	Not reported	Not reported	Not reported

Serum VCAM-1 on Day 3

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	106
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	27

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	1213.84	962.38	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	1044.96	870.11	Not reported	Not reported	Not reported

Serum VCAM-1 on Day 7

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	123
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	1224.58	1069.13	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	1209.51	780.31	Not reported	Not reported	Not reported

Serum VCAM-1 on Week 2

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	113
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	26

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	891.64	726.10	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	977.88	919.47	Not reported	Not reported	Not reported

Serum VCAM-1 on Week 4

Analysis denominator · Participants

Group	Source count
Axicabtagene Ciloleucel (Follicular Lymphoma)	118
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	28

Values in ng/L · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Axicabtagene Ciloleucel (Follicular Lymphoma)	981.67	879.87	Not reported	Not reported	Not reported
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)	930.89	885.51	Not reported	Not reported	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
spread
398.03
value
330.54
group Id
OG001
spread
218.42
value
207.63
denoms
counts
group Id
OG000
value
122
group Id
OG001
value
28
units
Participants
title
Serum Ferritin on Baseline
categories
measurements
group Id
OG000
spread
502.07
value
503.99
group Id
OG001
spread
337.82
value
398.49
denoms
counts
group Id
OG000
value
121
group Id
OG001
value
28
units
Participants
title
Serum Ferritin on Day 0
categories
measurements
group Id
OG000
spread
457.18
value
541.51
group Id
OG001
spread
414.90
value
487.39
denoms
counts
group Id
OG000
value
106
group Id
OG001
value
27
units
Participants
title
Serum Ferritin on Day 3
categories
measurements
group Id
OG000
spread
782.98
value
779.75
group Id
OG001
spread
4837.56
value
1820.38
denoms
counts
group Id
OG000
value
123
group Id
OG001
value
28
units
Participants
title
Serum Ferritin on Day 7
categories
measurements
group Id
OG000
spread
787.70
value
741.76
group Id
OG001
spread
1546.07
value
959.49
denoms
counts
group Id
OG000
value
113
group Id
OG001
value
26
units
Participants
title
Serum Ferritin on Week 2
categories
measurements
group Id
OG000
spread
605.94
value
528.83
group Id
OG001
spread
459.54
value
478.47
denoms
counts
group Id
OG000
value
118
group Id
OG001
value
28
units
Participants
title
Serum Ferritin on Week 4
categories
measurements
group Id
OG000
spread
833.80
value
876.99
group Id
OG001
spread
430.14
value
709.71
denoms
counts
group Id
OG000
value
122
group Id
OG001
value
28
units
Participants
title
Serum ICAM-1 on Baseline
categories
measurements
group Id
OG000
spread
854.35
value
834.87
group Id
OG001
spread
365.92
value
642.60
denoms
counts
group Id
OG000
value
121
group Id
OG001
value
28
units
Participants
title
Serum ICAM-1 on Day 0
categories
measurements
group Id
OG000
spread
904.79
value
964.45
group Id
OG001
spread
621.84
value
792.47
denoms
counts
group Id
OG000
value
106
group Id
OG001
value
27
units
Participants
title
Serum ICAM-1 on Day 3
categories
measurements
group Id
OG000
spread
846.56
value
924.99
group Id
OG001
spread
618.96
value
934.02
denoms
counts
group Id
OG000
value
123
group Id
OG001
value
28
units
Participants
title
Serum ICAM-1 on Day 7
categories
measurements
group Id
OG000
spread
605.03
value
695.15
group Id
OG001
spread
438.71
value
696.77
denoms
counts
group Id
OG000
value
113
group Id
OG001
value
26
units
Participants
title
Serum ICAM-1 on Week 2
categories
measurements
group Id
OG000
spread
656.46
value
671.32
group Id
OG001
spread
487.67
value
614.92
denoms
counts
group Id
OG000
value
118
group Id
OG001
value
28
units
Participants
title
Serum ICAM-1 on Week 4

denoms

counts
group Id
OG000
value
124
group Id
OG001
value
28
units
Participants

description

Serum analytes: Serum Ferritin, Serum intercellular adhesion molecule-1 (ICAM-1), Serum interleukin-2 receptor (IL-2 R) alpha, Serum Perforin and Serum vascular cell adhesion molecule-1 (VCAM-1).

dispersion Type

Standard Deviation

groups

description
Participants with r/r B-cell iNHL subtype of FL received the following treatment during the study: * A conditioning chemotherapy regimen of fludarabine 30 mg/m\^2/day IV and cyclophosphamide 500 mg/m\^2/day IV for 3 days (Day -5 to Day -3). * A single IV infusion at a target dose of 2×10\^6 anti-CD19 CAR transduced autologous T cells/kg on Day 0.
id
OG000
title
Axicabtagene Ciloleucel (Follicular Lymphoma)
description
Participants with r/r B-cell iNHL subtype of MZL received the following treatment during the study: * A conditioning chemotherapy regimen of fludarabine 30 mg/m\^2/day IV and cyclophosphamide 500 mg/m\^2/day IV for 3 days (Day -5 to Day -3). * A single IV infusion at a target dose of 2×10\^6 anti-CD19 CAR transduced autologous T cells/kg on Day 0.
id
OG001
title
Axicabtagene Ciloleucel (Marginal Zone Lymphoma)

param Type

MEAN

population Description

Participants in the Safety Analysis Set with available data were analyzed.

reporting Status

POSTED

time Frame

Baseline (at enrollment), predose: Day 0, postdose: Day 3, Day 7, Week 2, Week 4

title

Levels of Serum Ferritin, Serum ICAM-1, Serum IL-2 R Alpha, Serum Perforin and Serum VCAM-1

type

SECONDARY

unit Of Measure

ng/L

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Preserved source evidence · Not medical advice