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NCT03031730 · BASELINE

Baseline characteristics

Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma · Source last updated 2026-02-10

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      6
    2. group Id
      BG001
      value
      10
    3. group Id
      BG002
      value
      0
    4. group Id
      BG003
      value
      0
    5. group Id
      BG004
      value
      0
    6. group Id
      BG005
      value
      16
    units
    Participants
groups
  1. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG000
    title
    Part A (Dose-escalation) 60 mg
  2. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG001
    title
    Part A (Dose-escalation) 90 mg
  3. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG002
    title
    Part A (Dose-escalation) 120 mg
  4. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG003
    title
    Part A (Dose-escalation) 190 mg
  5. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG004
    title
    Part A (Dose-escalation) 240 mg
  6. description
    Total of all reporting groups
    id
    BG005
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        <=18 years
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          6
        3. group Id
          BG005
          value
          9
        title
        Between 18 and 65 years
      3. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          4
        3. group Id
          BG005
          value
          7
        title
        >=65 years
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Categorical
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          4
        3. group Id
          BG005
          value
          7
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          6
        3. group Id
          BG005
          value
          9
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          2
        3. group Id
          BG005
          value
          5
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          8
        3. group Id
          BG005
          value
          11
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG005
          value
          1
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          2
        3. group Id
          BG005
          value
          2
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          6
        3. group Id
          BG005
          value
          10
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG005
          value
          3
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          6
        2. group Id
          BG001
          value
          10
        3. group Id
          BG005
          value
          16
      title
      United States
    param Type
    NUMBER
    title
    Region of Enrollment
    unit Of Measure
    participants
population Description
Relapsed and/or refractory TP53 WT Multiple Myeloma subjects with 1-3 lines of prior therapy.
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      6
    2. group Id
      BG001
      value
      10
    3. group Id
      BG002
      value
      0
    4. group Id
      BG003
      value
      0
    5. group Id
      BG004
      value
      0
    6. group Id
      BG005
      value
      16
    units
    Participants
groups
  1. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG000
    title
    Part A (Dose-escalation) 60 mg
  2. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG001
    title
    Part A (Dose-escalation) 90 mg
  3. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG002
    title
    Part A (Dose-escalation) 120 mg
  4. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG003
    title
    Part A (Dose-escalation) 190 mg
  5. description
    Escalating doses of KRT-232 (DL1 60 mg, DL2 90 mg, DL3 120 mg, DL4 190 mg, DL5 240 mg) in combination with Carfilzomib, Lenalidomide, Dexamethasone (KRd)
    id
    BG004
    title
    Part A (Dose-escalation) 240 mg
  6. description
    Total of all reporting groups
    id
    BG005
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        <=18 years
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          6
        3. group Id
          BG005
          value
          9
        title
        Between 18 and 65 years
      3. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          4
        3. group Id
          BG005
          value
          7
        title
        >=65 years
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Age, Categorical
    unit Of Measure
    Participants
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          4
        3. group Id
          BG005
          value
          7
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          6
        3. group Id
          BG005
          value
          9
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          2
        3. group Id
          BG005
          value
          5
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          8
        3. group Id
          BG005
          value
          11
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG005
          value
          1
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          2
        3. group Id
          BG005
          value
          2
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          6
        3. group Id
          BG005
          value
          10
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG005
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG005
          value
          3
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          6
        2. group Id
          BG001
          value
          10
        3. group Id
          BG005
          value
          16
      title
      United States
    param Type
    NUMBER
    title
    Region of Enrollment
    unit Of Measure
    participants
population Description
Relapsed and/or refractory TP53 WT Multiple Myeloma subjects with 1-3 lines of prior therapy.

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Preserved source evidence · Not medical advice