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NCT02923349 · BASELINE

Baseline characteristics

A Phase 1/2, Open-Label, Dose-Escalation, Safety Study of INCAGN01949 in Subjects With Advanced or Metastatic Solid Tumors · Source last updated 2025-08-24

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      4
    2. group Id
      BG001
      value
      4
    3. group Id
      BG002
      value
      22
    4. group Id
      BG003
      value
      18
    5. group Id
      BG004
      value
      23
    6. group Id
      BG005
      value
      12
    7. group Id
      BG006
      value
      4
    8. group Id
      BG007
      value
      87
    units
    Participants
groups
  1. description
    INCAGN01949 7mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG000
    title
    PART 1 Dose 1 (7 mg)
  2. description
    INCAGN01949 20mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG001
    title
    PART 1 Dose 2 (20 mg)
  3. description
    INCAGN01949 70mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG002
    title
    PART 1 Dose 3 (70 mg)
  4. description
    INCAGN01949 200mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG003
    title
    PART 1 Dose 4 (200 mg)
  5. description
    INCAGN01949 350mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG004
    title
    PART 1 Dose 5 (350 mg)
  6. description
    INCAGN01949 700mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG005
    title
    PART 1 Dose 6 (700 mg)
  7. description
    INCAGN01949 1400mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG006
    title
    PART 1 Dose 7 (1400 mg)
  8. description
    Total of all reporting groups
    id
    BG007
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          16.24
          value
          54.3
        2. group Id
          BG001
          spread
          12.63
          value
          63.8
        3. group Id
          BG002
          spread
          14.27
          value
          56.8
        4. group Id
          BG003
          spread
          12.78
          value
          58.9
        5. group Id
          BG004
          spread
          12.44
          value
          58.1
        6. group Id
          BG005
          spread
          9.93
          value
          61.3
        7. group Id
          BG006
          spread
          24.50
          value
          52.8
        8. group Id
          BG007
          spread
          13.24
          value
          58.2
    dispersion Type
    STANDARD_DEVIATION
    param Type
    GEOMETRIC_MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          14
        4. group Id
          BG003
          value
          12
        5. group Id
          BG004
          value
          17
        6. group Id
          BG005
          value
          3
        7. group Id
          BG006
          value
          2
        8. group Id
          BG007
          value
          53
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          6
        5. group Id
          BG004
          value
          6
        6. group Id
          BG005
          value
          9
        7. group Id
          BG006
          value
          2
        8. group Id
          BG007
          value
          34
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          19
        4. group Id
          BG003
          value
          17
        5. group Id
          BG004
          value
          23
        6. group Id
          BG005
          value
          9
        7. group Id
          BG006
          value
          4
        8. group Id
          BG007
          value
          79
      title
      White/Caucasian
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          1
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          4
      title
      Asian
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          2
      title
      Other
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          2
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          2
      title
      Black/African American
    param Type
    NUMBER
    title
    Race/Ethnicity, Customized
    unit Of Measure
    participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          1
        7. group Id
          BG006
          value
          1
        8. group Id
          BG007
          value
          4
      title
      Hispanic or Latino
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          19
        4. group Id
          BG003
          value
          16
        5. group Id
          BG004
          value
          22
        6. group Id
          BG005
          value
          11
        7. group Id
          BG006
          value
          2
        8. group Id
          BG007
          value
          78
      title
      Not Hispanic or Latino
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        5. group Id
          BG004
          value
          1
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          1
        8. group Id
          BG007
          value
          4
      title
      Not Reported
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
      title
      Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      4
    2. group Id
      BG001
      value
      4
    3. group Id
      BG002
      value
      22
    4. group Id
      BG003
      value
      18
    5. group Id
      BG004
      value
      23
    6. group Id
      BG005
      value
      12
    7. group Id
      BG006
      value
      4
    8. group Id
      BG007
      value
      87
    units
    Participants
groups
  1. description
    INCAGN01949 7mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG000
    title
    PART 1 Dose 1 (7 mg)
  2. description
    INCAGN01949 20mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG001
    title
    PART 1 Dose 2 (20 mg)
  3. description
    INCAGN01949 70mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG002
    title
    PART 1 Dose 3 (70 mg)
  4. description
    INCAGN01949 200mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG003
    title
    PART 1 Dose 4 (200 mg)
  5. description
    INCAGN01949 350mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG004
    title
    PART 1 Dose 5 (350 mg)
  6. description
    INCAGN01949 700mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG005
    title
    PART 1 Dose 6 (700 mg)
  7. description
    INCAGN01949 1400mg administered intravenously over a 30-minute period on Day 1 of each cycle in subjects with advanced or metastatic solid tumors
    id
    BG006
    title
    PART 1 Dose 7 (1400 mg)
  8. description
    Total of all reporting groups
    id
    BG007
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          16.24
          value
          54.3
        2. group Id
          BG001
          spread
          12.63
          value
          63.8
        3. group Id
          BG002
          spread
          14.27
          value
          56.8
        4. group Id
          BG003
          spread
          12.78
          value
          58.9
        5. group Id
          BG004
          spread
          12.44
          value
          58.1
        6. group Id
          BG005
          spread
          9.93
          value
          61.3
        7. group Id
          BG006
          spread
          24.50
          value
          52.8
        8. group Id
          BG007
          spread
          13.24
          value
          58.2
    dispersion Type
    STANDARD_DEVIATION
    param Type
    GEOMETRIC_MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          14
        4. group Id
          BG003
          value
          12
        5. group Id
          BG004
          value
          17
        6. group Id
          BG005
          value
          3
        7. group Id
          BG006
          value
          2
        8. group Id
          BG007
          value
          53
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          6
        5. group Id
          BG004
          value
          6
        6. group Id
          BG005
          value
          9
        7. group Id
          BG006
          value
          2
        8. group Id
          BG007
          value
          34
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          19
        4. group Id
          BG003
          value
          17
        5. group Id
          BG004
          value
          23
        6. group Id
          BG005
          value
          9
        7. group Id
          BG006
          value
          4
        8. group Id
          BG007
          value
          79
      title
      White/Caucasian
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          1
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          4
      title
      Asian
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          2
      title
      Other
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          2
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          2
      title
      Black/African American
    param Type
    NUMBER
    title
    Race/Ethnicity, Customized
    unit Of Measure
    participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          1
        7. group Id
          BG006
          value
          1
        8. group Id
          BG007
          value
          4
      title
      Hispanic or Latino
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          4
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          19
        4. group Id
          BG003
          value
          16
        5. group Id
          BG004
          value
          22
        6. group Id
          BG005
          value
          11
        7. group Id
          BG006
          value
          2
        8. group Id
          BG007
          value
          78
      title
      Not Hispanic or Latino
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        5. group Id
          BG004
          value
          1
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          1
        8. group Id
          BG007
          value
          4
      title
      Not Reported
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
      title
      Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants

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Preserved source evidence · Not medical advice