Participant flow

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair · Source last updated 2026-10-01

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups

1. description

   Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV as a bolus on day 1, then continuously over 46 hours on days 1-3 of each cycle. Treatment repeats every 14 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive atezolizumab IV over 30-60 minutes on day 1 of each cycle, beginning in cycle 1 or 2. Treatment repeats every 14 days for up to 25 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI every 6 months for the first 2 years, then for years 3-5 or until evidence of relapse, whichever comes first. Patients may also undergo blood sample collection throughout the trial.\> \> Atezolizumab: Given IV\> \> Biospecimen Collection: Undergo blood sample collection\> \> Computed Tomography: Undergo CT\> \> Fluorouracil: Given IV\> \> Leucovorin Calcium: Given IV\> \> Magnetic Resonance Imaging: Undergo MRI\> \> Oxaliplatin: Given IV\> \> Quality-of-Life Assessment: Ancillary studies

   id

   FG000

   title

   Arm I (Combination Chemotherapy, Atezolizumab)

2. description

   Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV as a bolus on day 1, then continuously over 46 hours on days 1-3 of each cycle. Treatment repeats every 14 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI every 6 months for the first 2 years, then for years 3-5 or until evidence of relapse, whichever comes first. Patients may also undergo blood sample collection throughout the trial.\> \> Biospecimen Collection: Undergo blood sample collection\> \> Computed Tomography: Undergo CT\> \> Fluorouracil: Given IV\> \> Leucovorin Calcium: Given IV\> \> Magnetic Resonance Imaging: Undergo MRI\> \> Oxaliplatin: Given IV\> \> Quality-of-Life Assessment: Ancillary studies

   id

   FG001

   title

   Arm II (Combination Chemotherapy)

periods

1. drop Withdraws

   1. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      type

      Disease progression prior to beginning treatment

   2. reasons

      1. group Id

         FG000

         num Subjects

         4

      2. group Id

         FG001

         num Subjects

         25

      type

      Patient withdrawal prior to beginning treatment

   3. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         2

      type

      Unknown - prior to beginning treatment

   4. reasons

      1. group Id

         FG000

         num Subjects

         5

      2. group Id

         FG001

         num Subjects

         13

      type

      Disease progression

   5. reasons

      1. group Id

         FG000

         num Subjects

         62

      2. group Id

         FG001

         num Subjects

         32

      type

      Adverse Event

   6. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         2

      type

      Alternative therapy

   7. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         2

      type

      Complicating disease

   8. reasons

      1. group Id

         FG000

         num Subjects

         5

      2. group Id

         FG001

         num Subjects

         2

      type

      Death

   9. reasons

      1. group Id

         FG000

         num Subjects

         76

      2. group Id

         FG001

         num Subjects

         51

      type

      Withdrawal by Subject

   10. reasons

       1. group Id

          FG000

          num Subjects

          39

       2. group Id

          FG001

          num Subjects

          14

       type

       Other

   milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         355

      2. group Id

         FG001

         num Subjects

         357

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         163

      2. group Id

         FG001

         num Subjects

         214

      type

      COMPLETED

   3. achievements

      1. group Id

         FG000

         num Subjects

         192

      2. group Id

         FG001

         num Subjects

         143

      type

      NOT COMPLETED

   title

   Overall Study

Download exact source JSON → · Snapshot ctgov-results-aad7e863b8b06225cd4e94e7

Preserved source evidence · Not medical advice