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NCT02864992 · BASELINE

Baseline characteristics

Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION) · Source last updated 2026-07-14

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      152
    2. group Id
      BG001
      value
      24
    3. group Id
      BG002
      value
      161
    4. group Id
      BG003
      value
      337
    units
    Participants
groups
  1. description
    Participants received 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
    id
    BG000
    title
    Part 1: Cohort A: METex14 Skipping Alterations
  2. description
    Participants received 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
    id
    BG001
    title
    Part 1: Cohort B: MET Amplification
  3. description
    Participants received 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
    id
    BG002
    title
    Part 2: Cohort C: Confirmatory Part for METex14 Skipping Alterations
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          8.97
          value
          73.0
        2. group Id
          BG001
          spread
          9.17
          value
          62.3
        3. group Id
          BG002
          spread
          9.24
          value
          71.5
        4. group Id
          BG003
          spread
          9.47
          value
          71.5
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          73
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          86
        4. group Id
          BG003
          value
          162
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          79
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          75
        4. group Id
          BG003
          value
          175
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          3
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          148
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          157
        4. group Id
          BG003
          value
          328
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          6
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          38
        2. group Id
          BG001
          value
          07
        3. group Id
          BG002
          value
          68
        4. group Id
          BG003
          value
          113
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          01
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          02
        4. group Id
          BG003
          value
          3
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          108
        2. group Id
          BG001
          value
          17
        3. group Id
          BG002
          value
          87
        4. group Id
          BG003
          value
          212
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          05
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          04
        4. group Id
          BG003
          value
          9
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
population Description
All participants in Cohort A, Cohort B and Cohort C who were administered at least 1 dose of tepotinib.
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      152
    2. group Id
      BG001
      value
      24
    3. group Id
      BG002
      value
      161
    4. group Id
      BG003
      value
      337
    units
    Participants
groups
  1. description
    Participants received 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
    id
    BG000
    title
    Part 1: Cohort A: METex14 Skipping Alterations
  2. description
    Participants received 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
    id
    BG001
    title
    Part 1: Cohort B: MET Amplification
  3. description
    Participants received 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
    id
    BG002
    title
    Part 2: Cohort C: Confirmatory Part for METex14 Skipping Alterations
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          8.97
          value
          73.0
        2. group Id
          BG001
          spread
          9.17
          value
          62.3
        3. group Id
          BG002
          spread
          9.24
          value
          71.5
        4. group Id
          BG003
          spread
          9.47
          value
          71.5
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          73
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          86
        4. group Id
          BG003
          value
          162
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          79
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          75
        4. group Id
          BG003
          value
          175
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          3
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          148
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          157
        4. group Id
          BG003
          value
          328
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          6
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          38
        2. group Id
          BG001
          value
          07
        3. group Id
          BG002
          value
          68
        4. group Id
          BG003
          value
          113
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          01
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          02
        4. group Id
          BG003
          value
          3
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          108
        2. group Id
          BG001
          value
          17
        3. group Id
          BG002
          value
          87
        4. group Id
          BG003
          value
          212
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          05
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          04
        4. group Id
          BG003
          value
          9
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
population Description
All participants in Cohort A, Cohort B and Cohort C who were administered at least 1 dose of tepotinib.

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Preserved source evidence · Not medical advice