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NCT02793544 · OUTCOME

Donor Selection Characteristics: HLA Match

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide · Source last updated 2025-08-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
Pre-HCT

What was measured

Number of matched donor and recipient HLA allele pairs. A matched donor would have 8/8 HLA allele pairs matching; mismatched donors listed below have one to four mismatched HLA allele pairs at HLA-A, -B, -C, or -DRB1.

Groups in this outcome

Myeloablative Conditioning (MAC)

Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan

Reduced Intensity Conditioning (RIC)

Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation

Total

Total number of participants

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Myeloablative Conditioning (MAC)40
Reduced Intensity Conditioning (RIC)40
Total80

Reported measurements

Source class 1

7 out of 8 matching HLA allele pairs

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)26Not reportedNot reportedNot reportedNot reported
Reduced Intensity Conditioning (RIC)23Not reportedNot reportedNot reportedNot reported
Total49Not reportedNot reportedNot reportedNot reported

6 out of 8 matching HLA allele pairs

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)8Not reportedNot reportedNot reportedNot reported
Reduced Intensity Conditioning (RIC)11Not reportedNot reportedNot reportedNot reported
Total19Not reportedNot reportedNot reportedNot reported

5 out of 8 matching HLA allele pairs

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)5Not reportedNot reportedNot reportedNot reported
Reduced Intensity Conditioning (RIC)2Not reportedNot reportedNot reportedNot reported
Total7Not reportedNot reportedNot reportedNot reported

4 out of 8 matching HLA allele pairs

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)1Not reportedNot reportedNot reportedNot reported
Reduced Intensity Conditioning (RIC)4Not reportedNot reportedNot reportedNot reported
Total5Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        26
      2. group Id
        OG001
        value
        23
      3. group Id
        OG002
        value
        49
      title
      7 out of 8 matching HLA allele pairs
    2. measurements
      1. group Id
        OG000
        value
        8
      2. group Id
        OG001
        value
        11
      3. group Id
        OG002
        value
        19
      title
      6 out of 8 matching HLA allele pairs
    3. measurements
      1. group Id
        OG000
        value
        5
      2. group Id
        OG001
        value
        2
      3. group Id
        OG002
        value
        7
      title
      5 out of 8 matching HLA allele pairs
    4. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        4
      3. group Id
        OG002
        value
        5
      title
      4 out of 8 matching HLA allele pairs
denoms
  1. counts
    1. group Id
      OG000
      value
      40
    2. group Id
      OG001
      value
      40
    3. group Id
      OG002
      value
      80
    units
    Participants
description
Number of matched donor and recipient HLA allele pairs. A matched donor would have 8/8 HLA allele pairs matching; mismatched donors listed below have one to four mismatched HLA allele pairs at HLA-A, -B, -C, or -DRB1.
groups
  1. description
    Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan
    id
    OG000
    title
    Myeloablative Conditioning (MAC)
  2. description
    Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation
    id
    OG001
    title
    Reduced Intensity Conditioning (RIC)
  3. description
    Total number of participants
    id
    OG002
    title
    Total
param Type
COUNT_OF_PARTICIPANTS
reporting Status
POSTED
time Frame
Pre-HCT
title
Donor Selection Characteristics: HLA Match
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice