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NCT02793544 · OUTCOME

Donor Chimerism

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide · Source last updated 2025-08-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
percentage of donor chimerism
Interval / dispersion
Full Range
Time frame
28 days, 56 days, 100 days, 180 days, and 365 days post-transplant

What was measured

Peripheral blood chimerism (% of donor chimerism) in whole blood (unsorted). The degree of donor chimerism will be summarized using descriptive statistics.

Groups in this outcome

Myeloablative Conditioning (MAC)

Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan

Reduced Intensity Conditioning (RIC)

Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Myeloablative Conditioning (MAC)34
Reduced Intensity Conditioning (RIC)39

Reported measurements

28 days
Values in percentage of donor chimerism · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)100Not reported92100Not reported
Reduced Intensity Conditioning (RIC)99.1Not reported0100Not reported
56 days
Values in percentage of donor chimerism · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)100Not reported64100Not reported
Reduced Intensity Conditioning (RIC)100Not reported0100Not reported
100 days
Values in percentage of donor chimerism · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)100Not reported43100Not reported
Reduced Intensity Conditioning (RIC)100Not reported0100Not reported
180 days
Values in percentage of donor chimerism · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)100Not reported54.2100Not reported
Reduced Intensity Conditioning (RIC)100Not reported43.9100Not reported
365 days
Values in percentage of donor chimerism · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)100Not reported79.4100Not reported
Reduced Intensity Conditioning (RIC)100Not reported83.2100Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        92
        upper Limit
        100
        value
        100
      2. group Id
        OG001
        lower Limit
        0
        upper Limit
        100
        value
        99.1
    title
    28 days
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        64
        upper Limit
        100
        value
        100
      2. group Id
        OG001
        lower Limit
        0
        upper Limit
        100
        value
        100
    title
    56 days
  3. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        43
        upper Limit
        100
        value
        100
      2. group Id
        OG001
        lower Limit
        0
        upper Limit
        100
        value
        100
    title
    100 days
  4. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        54.2
        upper Limit
        100
        value
        100
      2. group Id
        OG001
        lower Limit
        43.9
        upper Limit
        100
        value
        100
    title
    180 days
  5. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        79.4
        upper Limit
        100
        value
        100
      2. group Id
        OG001
        lower Limit
        83.2
        upper Limit
        100
        value
        100
    title
    365 days
denoms
  1. counts
    1. group Id
      OG000
      value
      34
    2. group Id
      OG001
      value
      39
    units
    Participants
description
Peripheral blood chimerism (% of donor chimerism) in whole blood (unsorted). The degree of donor chimerism will be summarized using descriptive statistics.
dispersion Type
Full Range
groups
  1. description
    Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan
    id
    OG000
    title
    Myeloablative Conditioning (MAC)
  2. description
    Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation
    id
    OG001
    title
    Reduced Intensity Conditioning (RIC)
param Type
MEDIAN
reporting Status
POSTED
time Frame
28 days, 56 days, 100 days, 180 days, and 365 days post-transplant
title
Donor Chimerism
type
SECONDARY
unit Of Measure
percentage of donor chimerism

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice