NCT02793544 · OUTCOME

Grades II-IV Acute GVHD

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide · Source last updated 2025-08-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: NUMBER
Unit: percentage of participants
Interval / dispersion: 90% Confidence Interval
Time frame: 100 days

What was measured

Any skin, gastrointestinal or liver abnormalities fulfilling the BMT CTN Manual of Operations (2013) criteria of grades II-IV acute GVHD. A cumulative incidence will be computed along with a 90% CI.

Groups in this outcome

Myeloablative Conditioning (MAC)

Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan

Reduced Intensity Conditioning (RIC)

Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Myeloablative Conditioning (MAC)	40
Reduced Intensity Conditioning (RIC)	40

Reported measurements

Source class 1

Values in percentage of participants · Interval/dispersion: 90% Confidence Interval
Group	Value	Spread	Lower	Upper	Comment
Myeloablative Conditioning (MAC)	42.5	Not reported	29.8	55.7	Not reported
Reduced Intensity Conditioning (RIC)	32.5	Not reported	20.9	45.3	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
lower Limit
29.8
upper Limit
55.7
value
42.5
group Id
OG001
lower Limit
20.9
upper Limit
45.3
value
32.5

denoms

counts
group Id
OG000
value
40
group Id
OG001
value
40
units
Participants

description

Any skin, gastrointestinal or liver abnormalities fulfilling the BMT CTN Manual of Operations (2013) criteria of grades II-IV acute GVHD. A cumulative incidence will be computed along with a 90% CI.

dispersion Type

90% Confidence Interval

groups

description
Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan
id
OG000
title
Myeloablative Conditioning (MAC)
description
Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation
id
OG001
title
Reduced Intensity Conditioning (RIC)

param Type

NUMBER

reporting Status

POSTED

time Frame

100 days

title

Grades II-IV Acute GVHD

type

SECONDARY

unit Of Measure

percentage of participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice