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NCT02793544 · OUTCOME

Progression-free Survival

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide · Source last updated 2025-08-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
percentage of participants
Interval / dispersion
90% Confidence Interval
Time frame
180 days and 365 days post-transplant

What was measured

Time from HCT until the documentation of disease progression / relapse or death due to any cause, whichever occurs first. Progression-free survival probability and 90% CI will be calculated by the Kaplan Meier product limit estimator.

Groups in this outcome

Myeloablative Conditioning (MAC)

Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan

Reduced Intensity Conditioning (RIC)

Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Myeloablative Conditioning (MAC)40
Reduced Intensity Conditioning (RIC)40

Reported measurements

180 days
Values in percentage of participants · Interval/dispersion: 90% Confidence Interval
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)69.9Not reported57.481.1Not reported
Reduced Intensity Conditioning (RIC)72.5Not reported60.383.2Not reported
365 days
Values in percentage of participants · Interval/dispersion: 90% Confidence Interval
GroupValueSpreadLowerUpperComment
Myeloablative Conditioning (MAC)62.1Not reported49.274.3Not reported
Reduced Intensity Conditioning (RIC)67.5Not reported54.979Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        57.4
        upper Limit
        81.1
        value
        69.9
      2. group Id
        OG001
        lower Limit
        60.3
        upper Limit
        83.2
        value
        72.5
    title
    180 days
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        49.2
        upper Limit
        74.3
        value
        62.1
      2. group Id
        OG001
        lower Limit
        54.9
        upper Limit
        79
        value
        67.5
    title
    365 days
denoms
  1. counts
    1. group Id
      OG000
      value
      40
    2. group Id
      OG001
      value
      40
    units
    Participants
description
Time from HCT until the documentation of disease progression / relapse or death due to any cause, whichever occurs first. Progression-free survival probability and 90% CI will be calculated by the Kaplan Meier product limit estimator.
dispersion Type
90% Confidence Interval
groups
  1. description
    Participants received one of three regimens: cyclophosphamide and total body irradiation; busulfan and cyclophosphamide; or fludarabine and busulfan
    id
    OG000
    title
    Myeloablative Conditioning (MAC)
  2. description
    Participants received one of two regimens: fludarabine, cyclophosphamide, and low-dose total body irradiation
    id
    OG001
    title
    Reduced Intensity Conditioning (RIC)
param Type
NUMBER
reporting Status
POSTED
time Frame
180 days and 365 days post-transplant
title
Progression-free Survival
type
SECONDARY
unit Of Measure
percentage of participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice