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NCT02773030 · OUTCOME

Tmax

A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma · Source last updated 2026-03-20

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
Hours
Interval / dispersion
Full Range
Time frame
From Cycle 1 Day 1 to Cycle 1 Day 15 (15 days)

What was measured

Tmax is defined is the time to maximum plasma concentration.

Analysis population: All treated population with atleast 1 evaluable Pharmacokentic sample

Groups in this outcome

Cohort A: Treatment 1

CC220 0.30mg

Cohort A: Treatment 2

CC220 0.45mg

Cohort A: Treatment 3

CC220 0.60mg

Cohort A: Treatment 4

CC220 0.75mg

Cohort A: Treatment 5

CC220 0.90mg

Cohort A: Treatment 6

CC220 1.0mg

Cohort B: Treatment 1

CC220 0.30mg + DEX

Cohort B: Treatment 2

CC220 0.45mg + DEX

Cohort B: Treatment 3

CC220 0.60mg + DEX

Cohort B: Treatment 4

CC220 0.75mg + DEX

Cohort B: Treatment 5

CC220 0.90mg + DEX

Cohort B: Treatment 6

CC220 1.0mg + DEX

Cohort B: Treatment 7

CC220 1.1mg + DEX

Cohort B: Treatment 8

CC220 1.2mg + DEX

Cohort B: Treatment 9

CC220 1.3.mg + DEX

Cohort B: Treatment 10

CC220 1.6mg + DEX

Cohort D: Treatment 1

CC220 + DEX

Cohort E: Treatment 1

CC220 1.0mg + DARA + DEX

Cohort E: Treatment 2

CC220 1.1mg + DARA + DEX

Cohort E: Treatment 3

CC220 1.2mg + DARA + DEX

Cohort E: Treatment 4

CC220 1.3mg + DARA + DEX

Cohort E: Treatment 5

CC220 1.6mg + DARA + DEX

Cohort F: Treatment 1

CC220 1.0mg + BORT + DEX

Cohort F: Treatment 2

CC220 1.1mg + BORT + DEX

Cohort F: Treatment 3

CC220 1.3mg + BORT + DEX

Cohort F: Treatment 4

CC220 1.6mg + BORT + DEX

Cohort G: Treatment 1

CC220 1.1mg + CFZ + DEX

Cohort G: Treatment 2

CC220 1.3mg + CFZ + DEX

Cohort G: Treatment 3

CC220 1.6mg + CFZ + DEX

Cohort H1

CC220 + DEX

Cohort H2

CC220 + DEX

Cohort I

CC220 + DEX

Cohort J1: Treatment 1

CC220Vd 1.0mg + NE-ASCT

Cohort J1: Treatment 2

CC220Vd 1.6mg + NE-ASCT

Cohort K: Treatment 1

CC220 1.0mg + DARA + DEX

Cohort K: Treatment 2

CC220 1.3mg + DARA + DEX

Cohort K: Treatment 3

CC220 1.6mg + DARA + DEX

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Cohort A: Treatment 11
Cohort A: Treatment 22
Cohort A: Treatment 31
Cohort A: Treatment 42
Cohort A: Treatment 50
Cohort A: Treatment 60
Cohort B: Treatment 11
Cohort B: Treatment 20
Cohort B: Treatment 31
Cohort B: Treatment 40
Cohort B: Treatment 52
Cohort B: Treatment 62
Cohort B: Treatment 72
Cohort B: Treatment 81
Cohort B: Treatment 91
Cohort B: Treatment 102
Cohort D: Treatment 19
Cohort E: Treatment 11
Cohort E: Treatment 21
Cohort E: Treatment 31
Cohort E: Treatment 41
Cohort E: Treatment 50
Cohort F: Treatment 11
Cohort F: Treatment 20
Cohort F: Treatment 31
Cohort F: Treatment 40
Cohort G: Treatment 11
Cohort G: Treatment 21
Cohort G: Treatment 30
Cohort H16
Cohort H20
Cohort I0
Cohort J1: Treatment 10
Cohort J1: Treatment 20
Cohort K: Treatment 10
Cohort K: Treatment 20
Cohort K: Treatment 30

Reported measurements

CC-220

Analysis denominator · Participants

GroupSource count
Cohort A: Treatment 11
Cohort A: Treatment 22
Cohort A: Treatment 31
Cohort A: Treatment 42
Cohort A: Treatment 50
Cohort A: Treatment 60
Cohort B: Treatment 11
Cohort B: Treatment 20
Cohort B: Treatment 31
Cohort B: Treatment 40
Cohort B: Treatment 52
Cohort B: Treatment 62
Cohort B: Treatment 72
Cohort B: Treatment 81
Cohort B: Treatment 91
Cohort B: Treatment 102
Cohort D: Treatment 19
Cohort E: Treatment 11
Cohort E: Treatment 21
Cohort E: Treatment 31
Cohort E: Treatment 41
Cohort E: Treatment 50
Cohort F: Treatment 11
Cohort F: Treatment 20
Cohort F: Treatment 31
Cohort F: Treatment 40
Cohort G: Treatment 11
Cohort G: Treatment 21
Cohort G: Treatment 30
Cohort H16
Cohort H20
Cohort I0
Cohort J1: Treatment 10
Cohort J1: Treatment 20
Cohort K: Treatment 10
Cohort K: Treatment 20
Cohort K: Treatment 30
Values in Hours · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Cohort A: Treatment 13.0000Not reported3.00003.0000Not reported
Cohort A: Treatment 23.5585Not reported3.0004.117Not reported
Cohort A: Treatment 31.0000Not reported1.00001.0000Not reported
Cohort A: Treatment 41.9415Not reported1.9331.950Not reported
Cohort B: Treatment 13.0000Not reported3.00003.0000Not reported
Cohort B: Treatment 33.0000Not reported3.00003.0000Not reported
Cohort B: Treatment 52.0085Not reported1.0003.017Not reported
Cohort B: Treatment 62.9580Not reported1.9333.983Not reported
Cohort B: Treatment 72.4915Not reported2.0002.983Not reported
Cohort B: Treatment 82.0170Not reported2.01702.0170Not reported
Cohort B: Treatment 93.0000Not reported3.00003.0000Not reported
Cohort B: Treatment 102.9165Not reported2.8333.000Not reported
Cohort D: Treatment 12.0000Not reported2.00005.017Not reported
Cohort E: Treatment 13.850Not reported3.8503.850Not reported
Cohort E: Treatment 21.000Not reported1.0001.000Not reported
Cohort E: Treatment 32.000Not reported2.0002.000Not reported
Cohort E: Treatment 42.000Not reported2.0002.000Not reported
Cohort F: Treatment 15.50Not reported5.505.50Not reported
Cohort F: Treatment 32.00Not reported2.002.00Not reported
Cohort G: Treatment 11.8830Not reported1.88301.8830Not reported
Cohort G: Treatment 23.6670Not reported3.66706.6670Not reported
Cohort H13.9000Not reported1.9005.783Not reported
CC-17195

Analysis denominator · Participants

GroupSource count
Cohort A: Treatment 10
Cohort A: Treatment 20
Cohort A: Treatment 31
Cohort A: Treatment 42
Cohort A: Treatment 50
Cohort A: Treatment 60
Cohort B: Treatment 10
Cohort B: Treatment 20
Cohort B: Treatment 31
Cohort B: Treatment 40
Cohort B: Treatment 52
Cohort B: Treatment 61
Cohort B: Treatment 72
Cohort B: Treatment 81
Cohort B: Treatment 91
Cohort B: Treatment 102
Cohort D: Treatment 19
Cohort E: Treatment 10
Cohort E: Treatment 21
Cohort E: Treatment 31
Cohort E: Treatment 40
Cohort E: Treatment 50
Cohort F: Treatment 10
Cohort F: Treatment 20
Cohort F: Treatment 31
Cohort F: Treatment 40
Cohort G: Treatment 11
Cohort G: Treatment 21
Cohort G: Treatment 30
Cohort H16
Cohort H20
Cohort I0
Cohort J1: Treatment 10
Cohort J1: Treatment 20
Cohort K: Treatment 10
Cohort K: Treatment 20
Cohort K: Treatment 30
Values in Hours · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Cohort A: Treatment 31.0000Not reported1.00001.0000Not reported
Cohort A: Treatment 43.4500Not reported0.9675.933Not reported
Cohort B: Treatment 32.000Not reported2.0002.000Not reported
Cohort B: Treatment 54.9835Not reported2.0507.917Not reported
Cohort B: Treatment 62.9830Not reported2.98302.9830Not reported
Cohort B: Treatment 73.5085Not reported3.0004.017Not reported
Cohort B: Treatment 81.0170Not reported1.01701.0170Not reported
Cohort B: Treatment 93.0000Not reported3.0003.000Not reported
Cohort B: Treatment 105.4165Not reported2.8338.000Not reported
Cohort D: Treatment 15.0000Not reported2.0005.0000Not reported
Cohort E: Treatment 21.000Not reported1.0001.000Not reported
Cohort E: Treatment 32.000Not reported2.0002.000Not reported
Cohort F: Treatment 34.00Not reported4.004.00Not reported
Cohort G: Treatment 17.1000Not reported7.10007.1000Not reported
Cohort G: Treatment 23.6670Not reported3.66703.6670Not reported
Cohort H16.7415Not reported1.9008.133Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        3.0000
        upper Limit
        3.0000
        value
        3.0000
      2. group Id
        OG001
        lower Limit
        3.000
        upper Limit
        4.117
        value
        3.5585
      3. group Id
        OG002
        lower Limit
        1.0000
        upper Limit
        1.0000
        value
        1.0000
      4. group Id
        OG003
        lower Limit
        1.933
        upper Limit
        1.950
        value
        1.9415
      5. group Id
        OG006
        lower Limit
        3.0000
        upper Limit
        3.0000
        value
        3.0000
      6. group Id
        OG008
        lower Limit
        3.0000
        upper Limit
        3.0000
        value
        3.0000
      7. group Id
        OG010
        lower Limit
        1.000
        upper Limit
        3.017
        value
        2.0085
      8. group Id
        OG011
        lower Limit
        1.933
        upper Limit
        3.983
        value
        2.9580
      9. group Id
        OG012
        lower Limit
        2.000
        upper Limit
        2.983
        value
        2.4915
      10. group Id
        OG013
        lower Limit
        2.0170
        upper Limit
        2.0170
        value
        2.0170
      11. group Id
        OG014
        lower Limit
        3.0000
        upper Limit
        3.0000
        value
        3.0000
      12. group Id
        OG015
        lower Limit
        2.833
        upper Limit
        3.000
        value
        2.9165
    denoms
    1. counts
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        2
      3. group Id
        OG002
        value
        1
      4. group Id
        OG003
        value
        2
      5. group Id
        OG004
        value
        0
      6. group Id
        OG005
        value
        0
      7. group Id
        OG006
        value
        1
      8. group Id
        OG007
        value
        0
      9. group Id
        OG008
        value
        1
      10. group Id
        OG009
        value
        0
      11. group Id
        OG010
        value
        2
      12. group Id
        OG011
        value
        2
      units
      Participants
    title
    CC-220
  2. categories
    1. measurements
      1. group Id
        OG002
        lower Limit
        1.0000
        upper Limit
        1.0000
        value
        1.0000
      2. group Id
        OG003
        lower Limit
        0.967
        upper Limit
        5.933
        value
        3.4500
      3. group Id
        OG008
        lower Limit
        2.000
        upper Limit
        2.000
        value
        2.000
      4. group Id
        OG010
        lower Limit
        2.050
        upper Limit
        7.917
        value
        4.9835
      5. group Id
        OG011
        lower Limit
        2.9830
        upper Limit
        2.9830
        value
        2.9830
      6. group Id
        OG012
        lower Limit
        3.000
        upper Limit
        4.017
        value
        3.5085
      7. group Id
        OG013
        lower Limit
        1.0170
        upper Limit
        1.0170
        value
        1.0170
      8. group Id
        OG014
        lower Limit
        3.000
        upper Limit
        3.000
        value
        3.0000
      9. group Id
        OG015
        lower Limit
        2.833
        upper Limit
        8.000
        value
        5.4165
      10. group Id
        OG016
        lower Limit
        2.000
        upper Limit
        5.0000
        value
        5.0000
      11. group Id
        OG018
        lower Limit
        1.000
        upper Limit
        1.000
        value
        1.000
      12. group Id
        OG019
        lower Limit
        2.000
        upper Limit
        2.000
        value
        2.000
    denoms
    1. counts
      1. group Id
        OG000
        value
        0
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        1
      4. group Id
        OG003
        value
        2
      5. group Id
        OG004
        value
        0
      6. group Id
        OG005
        value
        0
      7. group Id
        OG006
        value
        0
      8. group Id
        OG007
        value
        0
      9. group Id
        OG008
        value
        1
      10. group Id
        OG009
        value
        0
      11. group Id
        OG010
        value
        2
      12. group Id
        OG011
        value
        1
      units
      Participants
    title
    CC-17195
denoms
  1. counts
    1. group Id
      OG000
      value
      1
    2. group Id
      OG001
      value
      2
    3. group Id
      OG002
      value
      1
    4. group Id
      OG003
      value
      2
    5. group Id
      OG004
      value
      0
    6. group Id
      OG005
      value
      0
    7. group Id
      OG006
      value
      1
    8. group Id
      OG007
      value
      0
    9. group Id
      OG008
      value
      1
    10. group Id
      OG009
      value
      0
    11. group Id
      OG010
      value
      2
    12. group Id
      OG011
      value
      2
    units
    Participants
description
Tmax is defined is the time to maximum plasma concentration.
dispersion Type
Full Range
groups
  1. description
    CC220 0.30mg
    id
    OG000
    title
    Cohort A: Treatment 1
  2. description
    CC220 0.45mg
    id
    OG001
    title
    Cohort A: Treatment 2
  3. description
    CC220 0.60mg
    id
    OG002
    title
    Cohort A: Treatment 3
  4. description
    CC220 0.75mg
    id
    OG003
    title
    Cohort A: Treatment 4
  5. description
    CC220 0.90mg
    id
    OG004
    title
    Cohort A: Treatment 5
  6. description
    CC220 1.0mg
    id
    OG005
    title
    Cohort A: Treatment 6
  7. description
    CC220 0.30mg + DEX
    id
    OG006
    title
    Cohort B: Treatment 1
  8. description
    CC220 0.45mg + DEX
    id
    OG007
    title
    Cohort B: Treatment 2
  9. description
    CC220 0.60mg + DEX
    id
    OG008
    title
    Cohort B: Treatment 3
  10. description
    CC220 0.75mg + DEX
    id
    OG009
    title
    Cohort B: Treatment 4
  11. description
    CC220 0.90mg + DEX
    id
    OG010
    title
    Cohort B: Treatment 5
  12. description
    CC220 1.0mg + DEX
    id
    OG011
    title
    Cohort B: Treatment 6
param Type
MEDIAN
population Description
All treated population with atleast 1 evaluable Pharmacokentic sample
reporting Status
POSTED
time Frame
From Cycle 1 Day 1 to Cycle 1 Day 15 (15 days)
title
Tmax
type
SECONDARY
unit Of Measure
Hours

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice