TriangleNCT02773030 · OUTCOME
Auc(Tau)
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- GEOMETRIC_MEAN
- Unit
- hr*ng/mL
- Interval / dispersion
- Geometric Coefficient of Variation
- Time frame
- From Cycle 1 Day 1 to Cycle 1 Day 15 (15 days)
What was measured
Area under the plasma concentration time-curve. AUC over the dosing interval.
Analysis population: All treated population with atleast 1 evaluable AUC (tau) Pharmacokentic sample
Groups in this outcome
Cohort A: Treatment 1
CC220 0.30mg
Cohort A: Treatment 2
CC220 0.45mg
Cohort A: Treatment 3
CC220 0.60mg
Cohort A: Treatment 4
CC220 0.75mg
Cohort A: Treatment 5
CC220 0.90mg
Cohort A: Treatment 6
CC220 1.0mg
Cohort B: Treatment 1
CC220 0.30mg + DEX
Cohort B: Treatment 2
CC220 0.45mg + DEX
Cohort B: Treatment 3
CC220 0.60mg + DEX
Cohort B: Treatment 4
CC220 0.75mg + DEX
Cohort B: Treatment 5
CC220 0.90mg + DEX
Cohort B: Treatment 6
CC220 1.0mg + DEX
Cohort B: Treatment 7
CC220 1.1mg + DEX
Cohort B: Treatment 8
CC220 1.2mg + DEX
Cohort B: Treatment 9
CC220 1.3.mg + DEX
Cohort B: Treatment 10
CC220 1.6mg + DEX
Cohort D: Treatment 1
CC220 + DEX
Cohort E: Treatment 1
CC220 1.0mg + DARA + DEX
Cohort E: Treatment 2
CC220 1.1mg + DARA + DEX
Cohort E: Treatment 3
CC220 1.2mg + DARA + DEX
Cohort E: Treatment 4
CC220 1.3mg + DARA + DEX
Cohort E: Treatment 5
CC220 1.6mg + DARA + DEX
Cohort F: Treatment 1
CC220 1.0mg + BORT + DEX
Cohort F: Treatment 2
CC220 1.1mg + BORT + DEX
Cohort F: Treatment 3
CC220 1.3mg + BORT + DEX
Cohort F: Treatment 4
CC220 1.6mg + BORT + DEX
Cohort G: Treatment 1
CC220 1.1mg + CFZ + DEX
Cohort G: Treatment 2
CC220 1.3mg + CFZ + DEX
Cohort G: Treatment 3
CC220 1.6mg + CFZ + DEX
Cohort H1
CC220 + DEX
Cohort H2
CC220 + DEX
Cohort I
CC220 + DEX
Cohort J1: Treatment 1
CC220Vd 1.0mg + NE-ASCT
Cohort J1: Treatment 2
CC220Vd 1.6mg + NE-ASCT
Cohort K: Treatment 1
CC220 1.0mg + DARA + DEX
Cohort K: Treatment 2
CC220 1.3mg + DARA + DEX
Cohort K: Treatment 3
CC220 1.6mg + DARA + DEX
| Group | Source count |
|---|---|
| Cohort A: Treatment 1 | 0 |
| Cohort A: Treatment 2 | 2 |
| Cohort A: Treatment 3 | 1 |
| Cohort A: Treatment 4 | 2 |
| Cohort A: Treatment 5 | 0 |
| Cohort A: Treatment 6 | 0 |
| Cohort B: Treatment 1 | 1 |
| Cohort B: Treatment 2 | 0 |
| Cohort B: Treatment 3 | 1 |
| Cohort B: Treatment 4 | 0 |
| Cohort B: Treatment 5 | 2 |
| Cohort B: Treatment 6 | 2 |
| Cohort B: Treatment 7 | 2 |
| Cohort B: Treatment 8 | 1 |
| Cohort B: Treatment 9 | 1 |
| Cohort B: Treatment 10 | 2 |
| Cohort D: Treatment 1 | 9 |
| Cohort E: Treatment 1 | 1 |
| Cohort E: Treatment 2 | 0 |
| Cohort E: Treatment 3 | 0 |
| Cohort E: Treatment 4 | 0 |
| Cohort E: Treatment 5 | 0 |
| Cohort F: Treatment 1 | 1 |
| Cohort F: Treatment 2 | 0 |
| Cohort F: Treatment 3 | 0 |
| Cohort F: Treatment 4 | 0 |
| Cohort G: Treatment 1 | 0 |
| Cohort G: Treatment 2 | 0 |
| Cohort G: Treatment 3 | 0 |
| Cohort H1 | 6 |
| Cohort H2 | 0 |
| Cohort I | 0 |
| Cohort J1: Treatment 1 | 0 |
| Cohort J1: Treatment 2 | 0 |
| Cohort K: Treatment 1 | 0 |
| Cohort K: Treatment 2 | 0 |
| Cohort K: Treatment 3 | 0 |
Reported measurements
CC-220
| Group | Source count |
|---|---|
| Cohort A: Treatment 1 | 0 |
| Cohort A: Treatment 2 | 2 |
| Cohort A: Treatment 3 | 1 |
| Cohort A: Treatment 4 | 2 |
| Cohort A: Treatment 5 | 0 |
| Cohort A: Treatment 6 | 0 |
| Cohort B: Treatment 1 | 1 |
| Cohort B: Treatment 2 | 0 |
| Cohort B: Treatment 3 | 1 |
| Cohort B: Treatment 4 | 0 |
| Cohort B: Treatment 5 | 2 |
| Cohort B: Treatment 6 | 2 |
| Cohort B: Treatment 7 | 2 |
| Cohort B: Treatment 8 | 1 |
| Cohort B: Treatment 9 | 1 |
| Cohort B: Treatment 10 | 2 |
| Cohort D: Treatment 1 | 5 |
| Cohort E: Treatment 1 | 1 |
| Cohort E: Treatment 2 | 0 |
| Cohort E: Treatment 3 | 0 |
| Cohort E: Treatment 4 | 0 |
| Cohort E: Treatment 5 | 0 |
| Cohort F: Treatment 1 | 1 |
| Cohort F: Treatment 2 | 0 |
| Cohort F: Treatment 3 | 0 |
| Cohort F: Treatment 4 | 0 |
| Cohort G: Treatment 1 | 0 |
| Cohort G: Treatment 2 | 0 |
| Cohort G: Treatment 3 | 0 |
| Cohort H1 | 5 |
| Cohort H2 | 0 |
| Cohort I | 0 |
| Cohort J1: Treatment 1 | 0 |
| Cohort J1: Treatment 2 | 0 |
| Cohort K: Treatment 1 | 0 |
| Cohort K: Treatment 2 | 0 |
| Cohort K: Treatment 3 | 0 |
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Cohort A: Treatment 2 | 22.5946 | 3.2396 | Not reported | Not reported | Not reported |
| Cohort A: Treatment 3 | 111.1790 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort A: Treatment 4 | 66.0413 | 11.0851 | Not reported | Not reported | Not reported |
| Cohort B: Treatment 1 | 20.1061 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 3 | 57.9410 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 5 | 119.8230 | 165.6553 | Not reported | Not reported | Not reported |
| Cohort B: Treatment 6 | 45.7555 | 12.3060 | Not reported | Not reported | Not reported |
| Cohort B: Treatment 7 | 96.1991 | 97.3452 | Not reported | Not reported | Not reported |
| Cohort B: Treatment 8 | 84.8140 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 9 | 101.8990 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 10 | 118.5940 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort D: Treatment 1 | 181.3199 | 55.8380 | Not reported | Not reported | Not reported |
| Cohort E: Treatment 1 | 14.5430 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort F: Treatment 1 | 18.3610 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort H1 | 196.8304 | 92.5871 | Not reported | Not reported | Not reported |
CC-17195
| Group | Source count |
|---|---|
| Cohort A: Treatment 1 | 0 |
| Cohort A: Treatment 2 | 0 |
| Cohort A: Treatment 3 | 1 |
| Cohort A: Treatment 4 | 0 |
| Cohort A: Treatment 5 | 0 |
| Cohort A: Treatment 6 | 0 |
| Cohort B: Treatment 1 | 0 |
| Cohort B: Treatment 2 | 0 |
| Cohort B: Treatment 3 | 0 |
| Cohort B: Treatment 4 | 0 |
| Cohort B: Treatment 5 | 2 |
| Cohort B: Treatment 6 | 0 |
| Cohort B: Treatment 7 | 1 |
| Cohort B: Treatment 8 | 1 |
| Cohort B: Treatment 9 | 1 |
| Cohort B: Treatment 10 | 0 |
| Cohort D: Treatment 1 | 5 |
| Cohort E: Treatment 1 | 0 |
| Cohort E: Treatment 2 | 0 |
| Cohort E: Treatment 3 | 0 |
| Cohort E: Treatment 4 | 0 |
| Cohort E: Treatment 5 | 0 |
| Cohort F: Treatment 1 | 0 |
| Cohort F: Treatment 2 | 0 |
| Cohort F: Treatment 3 | 0 |
| Cohort F: Treatment 4 | 0 |
| Cohort G: Treatment 1 | 0 |
| Cohort G: Treatment 2 | 0 |
| Cohort G: Treatment 3 | 0 |
| Cohort H1 | 4 |
| Cohort H2 | 0 |
| Cohort I | 0 |
| Cohort J1: Treatment 1 | 0 |
| Cohort J1: Treatment 2 | 0 |
| Cohort K: Treatment 1 | 0 |
| Cohort K: Treatment 2 | 0 |
| Cohort K: Treatment 3 | 0 |
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Cohort A: Treatment 3 | 5.0220 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 5 | 7.2409 | 67.0218 | Not reported | Not reported | Not reported |
| Cohort B: Treatment 7 | 11.5310 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 8 | 5.8280 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort B: Treatment 9 | 5.7470 | NA | Not reported | Not reported | Insufficient number of participants to calculate |
| Cohort D: Treatment 1 | 10.7279 | 51.1651 | Not reported | Not reported | Not reported |
| Cohort H1 | 20.1595 | 72.6176 | Not reported | Not reported | Not reported |
Complete source fields
- classes
- categories
- measurements
- group Id
- OG001
- spread
- 3.2396
- value
- 22.5946
- comment
- Insufficient number of participants to calculate
- group Id
- OG002
- spread
- NA
- value
- 111.1790
- group Id
- OG003
- spread
- 11.0851
- value
- 66.0413
- comment
- Insufficient number of participants to calculate
- group Id
- OG006
- spread
- NA
- value
- 20.1061
- comment
- Insufficient number of participants to calculate
- group Id
- OG008
- spread
- NA
- value
- 57.9410
- group Id
- OG010
- spread
- 165.6553
- value
- 119.8230
- group Id
- OG011
- spread
- 12.3060
- value
- 45.7555
- group Id
- OG012
- spread
- 97.3452
- value
- 96.1991
- comment
- Insufficient number of participants to calculate
- group Id
- OG013
- spread
- NA
- value
- 84.8140
- comment
- Insufficient number of participants to calculate
- group Id
- OG014
- spread
- NA
- value
- 101.8990
- comment
- Insufficient number of participants to calculate
- group Id
- OG015
- spread
- NA
- value
- 118.5940
- group Id
- OG016
- spread
- 55.8380
- value
- 181.3199
- denoms
- counts
- group Id
- OG000
- value
- 0
- group Id
- OG001
- value
- 2
- group Id
- OG002
- value
- 1
- group Id
- OG003
- value
- 2
- group Id
- OG004
- value
- 0
- group Id
- OG005
- value
- 0
- group Id
- OG006
- value
- 1
- group Id
- OG007
- value
- 0
- group Id
- OG008
- value
- 1
- group Id
- OG009
- value
- 0
- group Id
- OG010
- value
- 2
- group Id
- OG011
- value
- 2
- units
- Participants
- title
- CC-220
- categories
- measurements
- comment
- Insufficient number of participants to calculate
- group Id
- OG002
- spread
- NA
- value
- 5.0220
- group Id
- OG010
- spread
- 67.0218
- value
- 7.2409
- comment
- Insufficient number of participants to calculate
- group Id
- OG012
- spread
- NA
- value
- 11.5310
- comment
- Insufficient number of participants to calculate
- group Id
- OG013
- spread
- NA
- value
- 5.8280
- comment
- Insufficient number of participants to calculate
- group Id
- OG014
- spread
- NA
- value
- 5.7470
- group Id
- OG016
- spread
- 51.1651
- value
- 10.7279
- group Id
- OG029
- spread
- 72.6176
- value
- 20.1595
- denoms
- counts
- group Id
- OG000
- value
- 0
- group Id
- OG001
- value
- 0
- group Id
- OG002
- value
- 1
- group Id
- OG003
- value
- 0
- group Id
- OG004
- value
- 0
- group Id
- OG005
- value
- 0
- group Id
- OG006
- value
- 0
- group Id
- OG007
- value
- 0
- group Id
- OG008
- value
- 0
- group Id
- OG009
- value
- 0
- group Id
- OG010
- value
- 2
- group Id
- OG011
- value
- 0
- units
- Participants
- title
- CC-17195
- denoms
- counts
- group Id
- OG000
- value
- 0
- group Id
- OG001
- value
- 2
- group Id
- OG002
- value
- 1
- group Id
- OG003
- value
- 2
- group Id
- OG004
- value
- 0
- group Id
- OG005
- value
- 0
- group Id
- OG006
- value
- 1
- group Id
- OG007
- value
- 0
- group Id
- OG008
- value
- 1
- group Id
- OG009
- value
- 0
- group Id
- OG010
- value
- 2
- group Id
- OG011
- value
- 2
- units
- Participants
- description
- Area under the plasma concentration time-curve. AUC over the dosing interval.
- dispersion Type
- Geometric Coefficient of Variation
- groups
- description
- CC220 0.30mg
- id
- OG000
- title
- Cohort A: Treatment 1
- description
- CC220 0.45mg
- id
- OG001
- title
- Cohort A: Treatment 2
- description
- CC220 0.60mg
- id
- OG002
- title
- Cohort A: Treatment 3
- description
- CC220 0.75mg
- id
- OG003
- title
- Cohort A: Treatment 4
- description
- CC220 0.90mg
- id
- OG004
- title
- Cohort A: Treatment 5
- description
- CC220 1.0mg
- id
- OG005
- title
- Cohort A: Treatment 6
- description
- CC220 0.30mg + DEX
- id
- OG006
- title
- Cohort B: Treatment 1
- description
- CC220 0.45mg + DEX
- id
- OG007
- title
- Cohort B: Treatment 2
- description
- CC220 0.60mg + DEX
- id
- OG008
- title
- Cohort B: Treatment 3
- description
- CC220 0.75mg + DEX
- id
- OG009
- title
- Cohort B: Treatment 4
- description
- CC220 0.90mg + DEX
- id
- OG010
- title
- Cohort B: Treatment 5
- description
- CC220 1.0mg + DEX
- id
- OG011
- title
- Cohort B: Treatment 6
- param Type
- GEOMETRIC_MEAN
- population Description
- All treated population with atleast 1 evaluable AUC (tau) Pharmacokentic sample
- reporting Status
- POSTED
- time Frame
- From Cycle 1 Day 1 to Cycle 1 Day 15 (15 days)
- title
- Auc(Tau)
- type
- SECONDARY
- unit Of Measure
- hr*ng/mL
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Preserved source evidence · Not medical advice