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NCT02773030 · OUTCOME

Duration of Response

A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma · Source last updated 2026-03-20

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
Weeks
Interval / dispersion
Full Range
Time frame
On Average of (Cohort A:161.33, Cohort B: 63.74, Cohort D: 39.16, Cohort E: 89.56, Cohort F: 69.24, Cohort G: 80.93, Cohort H1: 77.11, Cohort H2: 42.71, Cohort I: 36.80, Cohort J: 92.36, Cohort K: 51.85) Weeks

What was measured

Duration of response is defined as time from the earliest date of documented response (PR or better) to the earliest date of disease progression per IMWG Uniform Response Criteria or death, whichever occurred first. Participants who do not have progression of disease or death will be censored on the last adequate response assessment date. Duration of response for responders will be summarized using Kaplan-Meier estimates by cohort and dose level as appropriate. Data will be collected and analyzed per Cohort Totals.

Analysis population: Safety Population - As per protocol, DOR and PFS will combine arms in the cohort for endpoint presentation

Groups in this outcome

Cohort A: Total

CC220

Cohort B: Total

CC220 + DEX

Cohort D: Total

CC220

Cohort E: Total

CC220 + DARA + DEX

Cohort F: Total

CC220 + BORT + DEX

Cohort G: Total

CC220 + CFZ + DEX

Cohort H1

CC220 + DEX

Cohort H2

CC220 + DEX

Cohort I

CC220 + DEX

Cohort J: Total

CC220 + NE-ASCT

Cohort K

CC220 + DARA + DEX

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Cohort A: Total3
Cohort B: Total29
Cohort D: Total28
Cohort E: Total24
Cohort F: Total17
Cohort G: Total10
Cohort H14
Cohort H21
Cohort I14
Cohort J: Total16
Cohort K71

Reported measurements

Source class 1
Values in Weeks · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Cohort A: Total176.14Not reported40.7267.1Not reported
Cohort B: Total45.00Not reported7.4239.3Not reported
Cohort D: Total28.64Not reported2.9146.1Not reported
Cohort E: Total59.21Not reported9.1265.1Not reported
Cohort F: Total69.29Not reported6.6255.1Not reported
Cohort G: Total66.64Not reported22.7238.3Not reported
Cohort H143.57Not reported12.1209.1Not reported
Cohort H242.71Not reported42.7142.71Not reported
Cohort I32.79Not reported8.080.1Not reported
Cohort J: Total104.71Not reported17.0123.1Not reported
Cohort K52.14Not reported21.077.3Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        40.7
        upper Limit
        267.1
        value
        176.14
      2. group Id
        OG001
        lower Limit
        7.4
        upper Limit
        239.3
        value
        45.00
      3. group Id
        OG002
        lower Limit
        2.9
        upper Limit
        146.1
        value
        28.64
      4. group Id
        OG003
        lower Limit
        9.1
        upper Limit
        265.1
        value
        59.21
      5. group Id
        OG004
        lower Limit
        6.6
        upper Limit
        255.1
        value
        69.29
      6. group Id
        OG005
        lower Limit
        22.7
        upper Limit
        238.3
        value
        66.64
      7. group Id
        OG006
        lower Limit
        12.1
        upper Limit
        209.1
        value
        43.57
      8. group Id
        OG007
        lower Limit
        42.71
        upper Limit
        42.71
        value
        42.71
      9. group Id
        OG008
        lower Limit
        8.0
        upper Limit
        80.1
        value
        32.79
      10. group Id
        OG009
        lower Limit
        17.0
        upper Limit
        123.1
        value
        104.71
      11. group Id
        OG010
        lower Limit
        21.0
        upper Limit
        77.3
        value
        52.14
denoms
  1. counts
    1. group Id
      OG000
      value
      3
    2. group Id
      OG001
      value
      29
    3. group Id
      OG002
      value
      28
    4. group Id
      OG003
      value
      24
    5. group Id
      OG004
      value
      17
    6. group Id
      OG005
      value
      10
    7. group Id
      OG006
      value
      4
    8. group Id
      OG007
      value
      1
    9. group Id
      OG008
      value
      14
    10. group Id
      OG009
      value
      16
    11. group Id
      OG010
      value
      71
    units
    Participants
description
Duration of response is defined as time from the earliest date of documented response (PR or better) to the earliest date of disease progression per IMWG Uniform Response Criteria or death, whichever occurred first. Participants who do not have progression of disease or death will be censored on the last adequate response assessment date. Duration of response for responders will be summarized using Kaplan-Meier estimates by cohort and dose level as appropriate. Data will be collected and analyzed per Cohort Totals.
dispersion Type
Full Range
groups
  1. description
    CC220
    id
    OG000
    title
    Cohort A: Total
  2. description
    CC220 + DEX
    id
    OG001
    title
    Cohort B: Total
  3. description
    CC220
    id
    OG002
    title
    Cohort D: Total
  4. description
    CC220 + DARA + DEX
    id
    OG003
    title
    Cohort E: Total
  5. description
    CC220 + BORT + DEX
    id
    OG004
    title
    Cohort F: Total
  6. description
    CC220 + CFZ + DEX
    id
    OG005
    title
    Cohort G: Total
  7. description
    CC220 + DEX
    id
    OG006
    title
    Cohort H1
  8. description
    CC220 + DEX
    id
    OG007
    title
    Cohort H2
  9. description
    CC220 + DEX
    id
    OG008
    title
    Cohort I
  10. description
    CC220 + NE-ASCT
    id
    OG009
    title
    Cohort J: Total
  11. description
    CC220 + DARA + DEX
    id
    OG010
    title
    Cohort K
param Type
MEDIAN
population Description
Safety Population - As per protocol, DOR and PFS will combine arms in the cohort for endpoint presentation
reporting Status
POSTED
time Frame
On Average of (Cohort A:161.33, Cohort B: 63.74, Cohort D: 39.16, Cohort E: 89.56, Cohort F: 69.24, Cohort G: 80.93, Cohort H1: 77.11, Cohort H2: 42.71, Cohort I: 36.80, Cohort J: 92.36, Cohort K: 51.85) Weeks
title
Duration of Response
type
SECONDARY
unit Of Measure
Weeks

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Preserved source evidence · Not medical advice