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NCT02767388 · OUTCOME

Change From Baseline Filter Task Performance at 1- and 3- Months

Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery · Source last updated 2023-09-29

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
change in proportion of correct trials
Interval / dispersion
Standard Deviation
Time frame
Collected at Study Induction, 1 month after Study Induction, 3 months after Study Induction

What was measured

Response accuracy - measured as the proportion of correct trials - is the primary outcome measure of the filter task. Changes in response accuracy were calculated by subtracting response accuracy at 1-month and 3-months from baseline response accuracy. Positive values correspond to an increase in accuracy and negative values correspond to a decline in accuracy.

Analysis population: The number analyzed differed between rows due to participant dropout from Month-1 to Month-3. Differences in number analyzed and numbers in the Participant Flow module were due to patient dropout and either: (1) a minority of patients requesting not to complete testing; or (2) difficulties with electrophysiology or stimulus presentation equipment.

Groups in this outcome

HM - Chemotherapy

Study patients diagnosed with HM that are scheduled to receive chemotherapy treatment.

HM - No Chemotherapy

Study patients diagnosed with HM that are scheduled to receive non-chemotherapy treatment options.

Healthy Controls

Study participants that are demographically matched to HM study patients and meet all inclusion criteria

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
HM - Chemotherapy8
HM - No Chemotherapy11
Healthy Controls11

Reported measurements

Change at 1-Month

Analysis denominator · Participants

GroupSource count
HM - Chemotherapy8
HM - No Chemotherapy11
Healthy Controls11
Values in change in proportion of correct trials · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
HM - Chemotherapy-.013.04Not reportedNot reportedNot reported
HM - No Chemotherapy.011.027Not reportedNot reportedNot reported
Healthy Controls-.004.034Not reportedNot reportedNot reported
Change at 3-Month

Analysis denominator · Participants

GroupSource count
HM - Chemotherapy8
HM - No Chemotherapy10
Healthy Controls11
Values in change in proportion of correct trials · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
HM - Chemotherapy.002.031Not reportedNot reportedNot reported
HM - No Chemotherapy-.006.025Not reportedNot reportedNot reported
Healthy Controls-.006.028Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        .04
        value
        -.013
      2. group Id
        OG001
        spread
        .027
        value
        .011
      3. group Id
        OG002
        spread
        .034
        value
        -.004
    denoms
    1. counts
      1. group Id
        OG000
        value
        8
      2. group Id
        OG001
        value
        11
      3. group Id
        OG002
        value
        11
      units
      Participants
    title
    Change at 1-Month
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        .031
        value
        .002
      2. group Id
        OG001
        spread
        .025
        value
        -.006
      3. group Id
        OG002
        spread
        .028
        value
        -.006
    denoms
    1. counts
      1. group Id
        OG000
        value
        8
      2. group Id
        OG001
        value
        10
      3. group Id
        OG002
        value
        11
      units
      Participants
    title
    Change at 3-Month
denoms
  1. counts
    1. group Id
      OG000
      value
      8
    2. group Id
      OG001
      value
      11
    3. group Id
      OG002
      value
      11
    units
    Participants
description
Response accuracy - measured as the proportion of correct trials - is the primary outcome measure of the filter task. Changes in response accuracy were calculated by subtracting response accuracy at 1-month and 3-months from baseline response accuracy. Positive values correspond to an increase in accuracy and negative values correspond to a decline in accuracy.
dispersion Type
Standard Deviation
groups
  1. description
    Study patients diagnosed with HM that are scheduled to receive chemotherapy treatment.
    id
    OG000
    title
    HM - Chemotherapy
  2. description
    Study patients diagnosed with HM that are scheduled to receive non-chemotherapy treatment options.
    id
    OG001
    title
    HM - No Chemotherapy
  3. description
    Study participants that are demographically matched to HM study patients and meet all inclusion criteria
    id
    OG002
    title
    Healthy Controls
param Type
MEAN
population Description
The number analyzed differed between rows due to participant dropout from Month-1 to Month-3. Differences in number analyzed and numbers in the Participant Flow module were due to patient dropout and either: (1) a minority of patients requesting not to complete testing; or (2) difficulties with electrophysiology or stimulus presentation equipment.
reporting Status
POSTED
time Frame
Collected at Study Induction, 1 month after Study Induction, 3 months after Study Induction
title
Change From Baseline Filter Task Performance at 1- and 3- Months
type
PRIMARY
unit Of Measure
change in proportion of correct trials

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice