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NCT02761187 · OUTCOME

Number of Participants With Myeloma Frailty Index

An Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Participants · Source last updated 2025-02-24

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
At Baseline

What was measured

Frailty is defined as the combination of unintentional weight loss, exhaustion, low physical activity, slow walking speed, and muscular weakness. The Myeloma Frailty Index is a composite index that was calculated using the points system, which produces a range of values from 0 to 5. Participants with score 0= fit, score 1= intermediate, and score ≥2= frail. Higher score indicates likeliness that the predicted outcome will result in frailty. The line of Therapy was determined at study entry.

Analysis population: All Enrolled Population included all participants who signed the inform consent form. Overall number of participants analyzed is the number of participants available for analysis.

Groups in this outcome

1st Line of Therapy

The most common treatment regimens prescribed in participants treated in 1st line of therapy were PI+IMiD, PI+AA, and PI treatment as part of their index regimen while enrolled in the study and were observed until study discontinuation, death or end of study (up to approximately 5 years).

2nd Line of Therapy

The most common treatment regimens prescribed in participants treated in 2nd line of therapy were PI+IMiD, IMiD, and PI treatment as part of their index regimen while enrolled in the study and were observed until study discontinuation, death or end of study (up to approximately 5 years).

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
1st Line of Therapy1761
2nd Line of Therapy1440

Reported measurements

0: Fit
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
1st Line of Therapy517Not reportedNot reportedNot reportedNot reported
2nd Line of Therapy428Not reportedNot reportedNot reportedNot reported
1: Intermediate
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
1st Line of Therapy218Not reportedNot reportedNot reportedNot reported
2nd Line of Therapy202Not reportedNot reportedNot reportedNot reported
≥2: Frail
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
1st Line of Therapy190Not reportedNot reportedNot reportedNot reported
2nd Line of Therapy130Not reportedNot reportedNot reportedNot reported
Missing
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
1st Line of Therapy836Not reportedNot reportedNot reportedNot reported
2nd Line of Therapy680Not reportedNot reportedNot reportedNot reported
Complete source fields
calculate Pct
false
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        517
      2. group Id
        OG001
        value
        428
    title
    0: Fit
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        218
      2. group Id
        OG001
        value
        202
    title
    1: Intermediate
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        190
      2. group Id
        OG001
        value
        130
    title
    ≥2: Frail
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        836
      2. group Id
        OG001
        value
        680
    title
    Missing
denoms
  1. counts
    1. group Id
      OG000
      value
      1761
    2. group Id
      OG001
      value
      1440
    units
    Participants
description
Frailty is defined as the combination of unintentional weight loss, exhaustion, low physical activity, slow walking speed, and muscular weakness. The Myeloma Frailty Index is a composite index that was calculated using the points system, which produces a range of values from 0 to 5. Participants with score 0= fit, score 1= intermediate, and score ≥2= frail. Higher score indicates likeliness that the predicted outcome will result in frailty. The line of Therapy was determined at study entry.
groups
  1. description
    The most common treatment regimens prescribed in participants treated in 1st line of therapy were PI+IMiD, PI+AA, and PI treatment as part of their index regimen while enrolled in the study and were observed until study discontinuation, death or end of study (up to approximately 5 years).
    id
    OG000
    title
    1st Line of Therapy
  2. description
    The most common treatment regimens prescribed in participants treated in 2nd line of therapy were PI+IMiD, IMiD, and PI treatment as part of their index regimen while enrolled in the study and were observed until study discontinuation, death or end of study (up to approximately 5 years).
    id
    OG001
    title
    2nd Line of Therapy
param Type
COUNT_OF_PARTICIPANTS
population Description
All Enrolled Population included all participants who signed the inform consent form. Overall number of participants analyzed is the number of participants available for analysis.
reporting Status
POSTED
time Frame
At Baseline
title
Number of Participants With Myeloma Frailty Index
type
PRIMARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice